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Danish doctors who studied 2.4 million kids say they have higher risk of conditions such as autism if mum had trouble
conceiving
theguardian.com, Monday 30 June 2014 14.20 BST
Three pregnant women
Researchers believe children born to women with fertility problems have a higher chance of developing mental health
issues. Photograph: i love images/Alamy
Children born to parents with fertility problems are more likely to develop psychiatric disorders than those with
healthier mothers and fathers, research suggests.
Doctors found higher rates of mental problems from anxiety and schizophrenia to autism in children whose parents
had issues getting pregnant.
The scientists could not explain the findings but said genetic faults or other biological problems with the mother or
father were more likely to blame than any fertility treatment they had.
"The exact mechanisms behind the observed increase in risk are still unknown but it is generally believed that underlying
infertility has a more important role in adverse effects in offspring than the treatment procedures," said Allan Jensen, an
epidemiologist at the University of Copenhagen in Denmark.One possibility is that faulty genes that raise the risk of
psychiatric diseases are more common in women or men with fertility problems. "If transferred to their offspring, this
may at least partly explain the increased risk of psychiatric diseases," Jensen said.
The Danish group used a database that links patient records, allowing them to study the medical histories of parents and
their children. They first searched for all children born in Denmark between 1969 and 2006. From a total of more than
2.4 million, they separated out 124,000 (5%) born to women with registered fertility problems, and 2.3 million (95%)
whose mothers had no such problems. A registered fertility problem recorded on a mother's medical notes might be due
to medical issues with either parent, although the researchers did not look specifically at fathers' health.
The researchers followed the children's medical histories, typically for 20 years, until 2009. During that time, children
born to parents with fertility problems had a 33% higher risk of psychiatric disorders. The children had a 27% higher risk
of schizophrenia and psychoses, a 37% higher risk of anxiety and neurotic disorders, an 28% greater risk of learning
difficulties, and a 22% higher risk of mental development disorders, including autism spectrum disorders, the scientists
found.
Further analyses of children aged 19 and under, and 20 and over found that the risks continued into adulthood.
Based on the figures, Jensen calculated that in Denmark, around 1.9% of all diagnosed psychiatric disorders are
associated with the mother or father's infertility. "This figure supports our interpretation of the results, that the
increased risk is real but modest," said Jensen, who will describe the work at the European Society of Human
Reproduction and Embryology meeting in Munich on Monday. The research has not been published in a peer-reviewed
journal.
Yacoub Khalaf, medical director of the assisted conception unit at Guy's Hospital in London, was sceptical of the figures.
"As a clinical observation, if they suggest the risk of mental retardation is increased by 28%, surely over the years we
would have seen an epidemic of mental retardation as a result of fertility treatment, which has never been observed.
The figures are staggering and at odds with anything that's been reported so far."
Allan Pacey, chair of the British Fertility Society, said the results were intriguing. "I suspect we are seeing an effect of
biology going on to affect these children or perhaps it's the social environment in which those young children were
brought up."
Previous research on children born after fertility treatment suggests that certain procedures, such as intracytoplasmic
sperm injection (ICSI), may raise the risk of birth defects, though the link is not definite.
But common fertility treatments do not seem to raise the risk of mental disorders. A major study published in the British
Medical Journal last year by another Danish team found that children born after IVF and ICSI were no more likely to have
mental disorders than children conceived naturally. The researchers did see a small increase of mental problems in
children born after their mothers had ovarian stimulation followed by intrauterine sperm injection.
This article was amended on 30 June 2014 to clarify that the fertility problems could have originated with either
parent, not just the mother.
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in 1903. Debussy was among the most influential composers of the late 19th and early 20th centuries, and his use of
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Debussy, he was one of the most prominent figures associated with Impressionist music. Much of his piano music,
chamber music, vocal music and orchestral music is part of the standard concert repertoire.Ravel's piano compositions,
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