Source: drug guide for nurses p470 Chemical: Inhibits acetyl cholinesterase thus improving cholinergic function by making more acetylcholine available.
Therapeutic: may temporarily lessen some of the dementia associated with Alzheimer disease.
Pharmacokinetics: Onset: unknown Peak: several week Duration: 6 week Drug half-life: 70hr
Source: drug guide for nurses p470 General indication: Mild to moderate dementia associated with Alzheimers disease.
Patients indication:
Source: drug guide for nurses p470
Contraindication Side effects Nursing Responsibilities Contraindication: Hypersensitivity to donepezil or piperidine derivatives.
Precautions: patient with underlying cardiac disease.
Drug interactions: Exaggerates muscle relaxation from succinylcholine.
Source: drug guide for nurses p470 , fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, weight loss, Source: Before: Assess cognitive function periodically during therapy.
During: Disturbed thought process
After: Improvement in cognitive function in patient with Alzheimers disease.
Source: drug guide for nurses p470 Adverse effect
Seizures, fainting, abnormal heart beats, and stomach ulcers also may occur