Immunology 1/27/2014 5:05:00 AM

Innate immune defense against pathogens include all the following except -
> cytotoxic t cell (adaptive immunity)

IL 7 -> bone marrow and thymus -> diffrentation -> lack -> no lymphocytes
Receptors def is found

B cells -> antibodies
T cells -> helper t cells

Myeloid cell
Monocyte (blood, in tissue its macrophage) , phagocytic, cd 14
positive
o Cd -> cellular diffrentation molecule
Dendritic cell -> found in epithelia
Neutrophils -> bloodstream, phagocytosis and activation of
bactericidal mechanisms
o Main killing cell against bacteria
Eosinophils -> killing of antibody coated parasites
Basophil -> no phagocytic, release -> histamine -> active against
allergic responses
Mast cells -> tissues mucosa and epithelia
Lymphoid cells

Antigen receptor of B lymph
Idiotype ->
Isotype -> antibody class
Heavy chain -> 9 classes
Light chain -> 2

B cell signal transduction complex:
Ig-alpha
Ig Beta
CD 19
CD 21

Clinical Out of Failed Gene rearrangement:
Omenn Syndrome -> AR, Misssense mutation in RAG -> Absesnce
bcells and decrease t cells
SCID -> AR, nonsense mutation in rag gene -> absence of B and T

Thymic shadow -> child of 1 week of age thymus block the heart on a xray

MHC
Class 1 -> HLA- A,HLA-B,HLA-C
Class 2 -> HLA-DP,DQ,DR

Leukocyte adhesion deficiency

Th 1 cytokines ->
IL2 ->
1/27/2014 5:05:00 AM

1/27/2014 5:05:00 AM