Peptide hormones

Example Precursor
molecule
Synthesis Target receptors Storage Signaling
route
Lipo and
hydro
philic/phobic
Peptide proteins,
polypeptides
Insulin,
glucagon,
ACTH, PTH,
GH
Amino acids Rough ER Membrane-
bound
Secretory
granules
Chanel
changes
Second
messenger
Hydrophilic
Peptide -
glycoproteins
TSH, LH, FSH
Peptide small
peptides
GnRH, ADH,
TRH
Amines -
catecholamines
Tyrosine Cytosol Membrane-
bound
Chromaffin
granules
Second
messenger
Hydrophilic
Amines thyroid
hormones
(Melatonin,
synthesized
by
tryphtophan,
hydrophilic)
Tyrosine Cytosol,
extracellular
colloid
Intracellular Colloid Gene
expression
Hydrophobic,
lipophilic
Steroids Cholesterol Stepwise
mitochondria and
sER
Intracellular No stored Gene
expression
Lipophilic
Hydrophobic