Cellular Injury and Adaptation I

1. Hypertrophy of Myocardium

Low mag. Note the color variation and broad areas with amorphous pink deposits/hyaline change
probably resulting from scarring after MI.

Notice the color and size variation in the myocytes nuclei. Also, notice the prevalence of fibroblasts/scar
tissue.


Myocytes are hypertrophied. Note the box car nuclei which are large and rectangular.

Close up. The gold-brown pigment, generally next to the nuclei, is lipofuscin. Lipofuscin is the result of
autophagy, and technically is oxidized lipid-protein complex.



2. Fatty Change of Liver (hepatic steatosis)

Low mag. Note relative pallor, but presence of normal hepatic architecture.

Note normal hepatic architecture. The varied size of vacuoles indicates micro- and macrovesicular fatty
change.


Cells with macrovesicular fatty change have nuclei which are flattened and pushed to the side, known as
a signet ring appearance. Hepatocytes are enlarges, and sinusoids are compressed and thus barely
visible.

3. Hyalinization, Coronary Artery

Low mag. The lumen of the arteriosclerotic vessel is reduced in size by its plaque and hyalinized wall.
The large purple deposits (star) are dystrophic calcifications.


Higher mag of glassy, pink hyaline change. Areas of dystrophic calcification (dark purple) contain
cholesterol clefts ( ()-shaped).


Close up.




4. Hyaline Change, Kidney

Low mag. You can see there is normal architecture. Were focusing on the cortex.


Notice that the general architecture is normal. Walls of arteries (afferent and efferent arterioles,
glomeruli) are thickened and have amorphous pale pink structureless appearance, i.e. hyaline change.

Nodular hyalinization
of glomerulus

Close up of glomeruli. Notice how the one above and at bottom right have flat, pink appearance of
hyalinization, within the glomerulus. Hyalinization of the kidney is typical of advanced diabetes.
Diffuse hyalinization
of glomerulus