Xuejun Wen, M.D., Ph.D. Assistant Professor of Bioengineering Assistant Professor of Cell Biology and Anatomy Assistant Professor of Orthopedic Surgery Introduction The bulk and surface properties of biomaterials used for medical implant directly influence the tissue-implant interface, dynamic interaction, short-term and long-term fate of the implant. Each material have specific bulk and surface properties or characteristics. These should be known before using for any medical application. The changes of above properties over time in vivo. These should also be know before using for any in vivo application. Although the properties of most materials are available from handbooks, journal publications, etc., these properties have to be tested in the context of the intended biomedical use. Cardiovascular---flowing blood contact. Cyclic mechanical loading Orthopedic---functional load bearing Dental---percutaneous Materials (Where they are?) Atoms Molecules Materials Parts: Implants, Scaffolds,. Protons, Neutrons, Electrons ? Atoms All matter is composed atoms Atoms of a give element have identical properties Different elements have different properties: How this may help us?
We can identify a molecule/material by identify each element in the
molecule/material. Atoms are not created or destroyed in chemical reactions (exclude nuclear reaction). Individual atoms can be visualized using Scanning Tunneling Microscope. Atoms Atoms contain Protons (+charge) Neutrons (no charge) Electrons (- charge) Protons + Neutrons = Nucleus (Heavy elements) Electrons (Light elements) Atoms have measurable masses. How to measure? Atomic Weight is average mass of an atom of an element. Why?
Mass spectrometer can be used to measure
Isotope (the number of neutrons is different) How we can use isotope for biomaterial research? Molecules Two or more atoms joined together by chemical bonds and form a molecule. Molecule will form if total energy of molecule is lower than the total energy of the separated atoms. Atoms combine in whole number ratio (no fractional atom). Molecular formula gives the composition of: Number of atom of each element present Molecular weight: sum of masses of atoms Ordinary samples (Materials) contain lots of molecules. Molecule will form if total energy of molecule is lower than the total energy of the separated atoms. NaCl Use IE (Ionization energy), EA (electron affinity), and Coulombs Law to find the energy Na: IE=496 KJ /Mol Cl: EA=-328 KJ /mol CoulombicEnergies=-861kJ /mol Bulk properties of materialsSolid state The states of matter: (Think about H 2 O)
Liquid Gas Solid Whats the difference between solids and liquids or gases?
Solids are held together by strong inter-atomic forces
Electronic and atomic structures and physical properties of the solids depend on the nature and strength of the inter-atomic bonds. Three types of strong or primary inter-atomic bonds Ionic, covalent, and metallic bonds The full account of the nature of these bonds have to be explained through the modern theory of quantum mechanics. (NOT our focus here) Ionic bonding Electron donor (metallic) atoms transfer one or more electrons to an electron acceptor (nonmetallic) atom. One becomes a cation(e.g., metal) and the other becomes anion (e.g., nonmetal) Cationsand anions are strongly attracted by electrostatic or Coulomb effect. This attraction constitutes the ionic bond. Examples include NaCl, MgO, Ionic bond and crystal structure Poor electrical conducting: due to that loosely bound electrons of each atoms are now tightly held in the locality of the ion bond Low chemical reactivity: low overall energy state. In ionic solids, there are many ions (cationsand anions). Ions are arranged in a way that each cationis surrounded by as many anions as possible to reduce the strong mutual repulsion of cations. This packing reduces the overall energy of the assemly/ordered arrangement, and called crystal structure. Crystal structure: Simple cubic Crystal structure: Face-centered-cubic (FCC) Crystal structure: Body-centered cubic (BCC) Crystal structure: Hexagonal close-packed (HCP) Covalent bonding When atoms have about equal tendency to donate or accept electrons, they do NOT form strong ionic bonds (They are going to Share rather than Donate). Covalent bonding is based on electron sharingrather than donation. Potential curve Carbon- An example of covalent bond Carbon (Diamond) Carbon (Graphite) Graphite Summary about bonding Two extremes Ionic bonding: electron donation/transfer (from positive ion to negative ion) Covalent bonding: electron sharing Most bonds are the combination of the two Polar covalent bonds: uneven electron sharing Electronegativity Electronegativityis a measure of the ability of an atom or molecule to attract electrons in the context of a chemical bond. The type of bond formed is largely determined by the difference in electronegativitybetween the atoms involved. Atoms with similar electronegativities(H 2 , N 2 ) will share an electron with each other and form a covalent bond. If the difference is too great, the electron will be permanently transferred to one atom and an ionic bond will form. If one atom pulls slightly harder than the other, a polar covalent bond will form (CO2). The reverse of electronegativity, the ability of an atom to lose electrons, is known as electropositivity. Electronegativity Lewis structures Lewis Structures of atoms: The chemical symbol for the atom is surrounded by a number of dots corresponding to the number of valence electrons. Lewis Structures for Ions of Elements: The chemical symbol for the element is surrounded by the number of valence electrons present in the ion. The whole structure is then placed within square brackets, with a superscript to indicate the charge on the ion. Atoms will gain or lose electrons in order to achieve a stable electronic configuration. Negative ions (anions) are formed when an atom gains electrons. Positive ions (cations) are formed when an atom loses electrons. Lewis Structures for Ionic Compounds: The overall charge on the compound must equal zero, that is, the number of electrons lost by one atom must equal the number of electrons gained by the other atom. The Lewis Structure (electron dot diagram) of each ion is used to construct the Lewis Structure (electron dot diagram) for the ionic compound. Lewis Structures for Covalent Compounds: Electrons in the Lewis Structure (electron dot diagram) are paired to show the bonding pair of electrons. Often the shared pair of electrons forming the covalent bond is circled Sometimes the bond itself is shown (-), these structures can be referred to as valence structures. Metal bonding Metal atoms, being strong electron donors, do not bond by either ionic or covalent processes. However, may metals have very high melting temperature indicating very strong inter-atomic bonds exist. The explanation is that: atoms arranged in an orderly, repeating, 3- D pattern, with the valence electrons migrating between the atoms like a gas. (Free electron model of metallic bonding). Imagine a metal crystal composed of positive ion cores, atoms without their valence electrons. Negative electrons circulate. Non-localized bonds in a metal allows plastic deformation Electron gas accounts for active chemical reactivity, high electric and thermal conductivity of metallic systems Weak bonding/Secondary bonding Weak bond significantly influence the properties of some solids, especially polymers. Van der Waalsbonding (Physical bonding): is weak when compared to primary/chemical bonding. It exists between virtually all atoms or molecules, but its presence may be obscured if any the 3 primary bonding types is present. Inert gases, between molecules in molecular structures that are covalently bonded. Dipole: Secondary bonding forces arise from atomic or molecular dipoles. (The separation of positive and negative portions of an atom or molecule) Hydrogen bonding: Covalent bonds between N-H as well as between O-H are quite polar, and the H atom can be considered as being partially positive. H atom is attracted fairly strongly to atoms which have lone pairs of electrons (such as O and N). The molecules involved to become weakly bonded, through the H atom. Hydrogen bonds are stronger than Van der Waalsbonds, but weaker than ionic bonds or covalent bonds. They play very important role in living systems. Van der Waalsbonding Van der Waalsbonding (graphite) Hydrogen bonding