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NANOMEDICINE

DESIGN AND APPLICATIONS OF MAGNETIC NANOMATERIALS,


NANOSENSORS AND NANOSYSTEMS
Vijay K. Varadan, Linfeng Chen, and Jining Xie

Chapter 4
Biomedical Applications of Magnetic Nanoparticles




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7-1-2011

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Content
4 Biomedical Applications of Magnetic Nanoparticles
4.1 Introduction
4.2 Diagnostic Applications
4.2.1 Enhancement of Magnetic Resonance Imaging
4.2.2 Magnetic Labeling
4.2.3 Spatially Resolved Magnetorelaxometry
4.2.4 Magnetic Separation and Purification
4.2.5 Biological Assay System
4.2.6 Biosensors
4.3 Therapeutic Applications
4.3.1 Drug and Gene Target Delivery
4.3.2 Hyperthermia Treatment
4.3.3 Eye Surgery
4.3.4 Antitumor Effects
4.4 Physiological Aspects
4.5 Toxic Effects

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1.4

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.
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quantum dot nanoparticle/nanocrystal
nanowire nanorods nanotube .

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superparamagnetism
.

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.15nm
. blocking temperature

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) (
.

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.
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. 10um
. 20-450nm 5-50nm
2nm .10-100nm

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functionalization .
.

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).(Salata 2004


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.(Pankhurst et al 2003) .
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hyperthermia


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) colloidal
(
: .

colloidal
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)
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: in vivo in
vitro .
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.
).(Tartaj et al 2003
in vivo
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Fe3O4 -Fe2O3 .-Fe3O4
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.

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