G (+) Aerobes (only) G (+) Aerboes & Anaerobes

B-Lactamase Resistant:Unasyn (ampicillin & sulbactam)

Dicloxacillin Carbapenems:
Unipen (Nafcillin) Invanz (ertapenem)
Bactoci (Oxacillin) Lincosamides:
Tetracyclines: Cleocin (Clindamycin)
Minocycline
Methacycline
Doxycycline
Tetracycline HCL
Macrolides:
Zithromax (Azithromycin)
Rifampin
Clindamycin ADRs:
Tetra ADRs: pseudomembranoue colitis
(-) bone, teeth, photosens
Vanco & Amino ADRs
Macrolide ADRs: nephrotoxic & ototoxic
prolong QT interval
Sulfa ADRs;
fever, rash, SJS, thrombocytopenia
SJS cause by Pencillin, Seizure, Sulfa,
Allopurinol meds
Anaerobes (Cant Breathe
Air)
o Clostridium, B. fragilis ,
Actionmyces
Anaerobes Pseudomonas
Chloramphenicol Piperacillin
Flagyl (Metronidazole) Zosyn (piperacillin & tazobactam)
Cleocin (Clindamycin) 3rd Gen Cephalosporins:
Fortaz (ceftazidime)
4th Gen Cephalosporins:
Chloramphenicol ADRs: Maxipime (cefepime)
gray baby & aplastic anemia Fluoroquinolones:
Ciprofloxacin
Metronidazole ADRs:
disulfram rxn & periph neuro C. Diff
Vancomycin (ORAL)
Flagyl (Metronidazole)
G (+) & G (-) Aerobes G (-) Aerobes (only)
1st Gen Cepalosporins: (PECK) Fluoroquinolones:
Keflex (cephalexin) Ciprofloxacin
Duricef (cephadroxil) Monobactams:
Ancef (cefazolin) Azactam (azetreonam)
2nd Gen Cephalosporins:
Ceftin & Zinacef (cefuroxime)
Mefoxin (cefoxitin)
3rd Gen Cephalosporins: Fluoroquinolones ADRs:
Omnicef (cefdinir) tendon rupture
Rocephin (ceftriaxone)
Fortaz (ceftazidime)
4th Gen Cephalosporins:
Maxipime (cefepime)
EX Spectrum Cephalosporins:
Teflaro (ceftaroline)
Aminoglycosides:
Gentamycin
Tobramycin
Amikacin
Sulfonamides: "treat UTI"
Bactrim (Trimethoprim sulfa)
Fluoroquinolones:
Levaquin (Levofloxacin)
Vibrio Bone penetration
Tetracyclines: Ciprofloxacin
Minocycline Doxycycline (Vibramycin)
Doxycycline (vibramycin) Cleocin (Clindamycin)
Zyvox (Linezolid)
* OM treatment
Broad Spectrum Ca MRSA
Zosyn (piperacillin & tazobactam) Tetracyclines:
Augmentin (amoxicillin & clav acid) Minocycline
Timentin (Ticarcillin & clav acid) Doxycycline (vibramycin)
Primaxin (Imipenem) Sulfonamides:
Fluoroquinolones: Bactrim (Trimethoprim sulfa)
Avelox (Moxifloxacin)
Nemonoxacin
Glycylcycline:
Tygacil (Tigecycline)
Protein Synthesis (-)'s
BUY AT 30
Aminoglycosides (B-cidial )
Tetracyclines (B-cidial )
CELL at 50
Chloramphenical (B-static )
Erythromycin (B-static )
Lincosamides "clinda" (B-static)
Linezolid
NO Renal Adjust VRSA
Zithromax (Azithromycin) Streptogramins:
Doxycycline (Vibramycin) Synercid (Quin/ Dalf)
Cleocin (Clindamycin) Glycylcycline:
Zyvox (Linezolid) Tygacil (Tigecycline)
Tygacil (Tigecycline) Zyvox (Linezolid)
Avelox (Moxifloxacin) Cyclinc Lipopepitde:
Cubicin (Daptomycin)
Ha MRSA
EX Spectrum Cephalosporins:
Teflaro (ceftaroline)
1st Gen Glycopeptides:
Vancomycin
Vibativ (Televancin)
Nemonoxacin
Streptogramins:
Synercid (Quin/ Dalf)
Oxazolidinones:
Zyvox (Linezolid)
Cyclinc Lipopepitde:
Cubicin (Daptomycin)
Glycylcycline:
Tygacil (Tigecycline)
VRE
Streptogramins:
Synercid (Quin/ Dalf)
Glycylcycline:
Tygacil (Tigecycline)
Zyvox (Linezolid)
Amphotericin B
MOA-binds to Ergosterol making membrane pores that allow leakage
Use - severe infections
ADRs - nephrotoxic, shakes, hypotension
Nystatin
MOA- binds to Ergosterol making membrane pores that allow leakage
Use - superficial candidia infection (oral candidasis) "Swish & Swallow"
Terbinafine (lamisil)
MOA- inhibits squalene epoxidase
Use - dermatophytes (Onychomycosis & T. pedis)
ADR- green vision, abnormal tatse, blood dyscarasis
Dosing - 250 mg qd x 3 months
Azoles
Fluconazole, Ketoconazole, Clotrimazole, Miconazole, Itraconazole, Voriconazole
MOA- inhibit fungal sterol (ergosterol) sythesis of 14-alpha demethylase
Use - systemic mycoses
ADR- (-) P450-3A4 & hormone synthesis, Liver dysfunction
Ketoconazole- gynecomastia
Dosing :
Itraconazole (sporanox)
-Pulse therpay- (2) 100 mg capsules bid for 1 wk per month x3
-Avoid in CHF patient
Fluconazole
-crosses the BBB and useful for treating fungal meningitis
Griseofluvin (Gris-PEG)
MOA- intereferes w/ microtubule function disrupting mitosis, accum in kerat tissue
Use - superficial infection (chronic tinea pedis)
ADR- tertatogenic, (+) P450 "warfarin", Diarrhea, Hepatotoxic
Flucytosine
MOA- inhibit RNA synthesis by conversion of 5-fluorouracil
Use - in combo w/ Ampho B for systemic mycosis
ADR- bone marrow suprresion
MOA- intereferes w/ microtubule function disrupting mitosis, accum in kerat tissue