Extrinsic Pathway Intrinsic Pathway Fasl / Fas

Fas Associated
Death Domain
(FADD)
Pro-caspase 8 inactivated initiator
Aggregation by 3 and cleavage
of Pro-caspases 8 molecules
Pro-caspase 8 activated initiator
Cytochrome C in the
intermembrane space
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Release of cytochrome C
and binding on Apaf-1
Apaf-1 aggregation et and biding of
4 associated Procaspase-9
Pro-caspase 9 Activation
Death Effector Domain (DED)
NH2
COOH
cleavage
sites
big subunit
small
subunit
Bcl-2
damaged
DNA
p53
bax/bax
Bid
tBid
Bcl-xl
Apaf-1
CAspase Recruitment
Domain (CARD)
Caspase 9 inactivated initiator
Pro-caspase 3 inactivated effector
Short Pro-Domain
Apoptosome
Caspase 3 activated effector
Grandzyme Perforine
bad
cleavage of cytosolic proteins
Keratin
Gelsolin
Actin
cleavage of nuclear proteins
Lamin
Actin
(BH3)
bak/bak
PUMA
Noxa
anti-apoptotic protein
inactivation by direct
binding
Binding and activation
of Bax/Bak
Outer mitochondrion menbrane
Caspases Cascade
Stress
p73/p63
Dvp
APOPTOSIS
T

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Nucleus
dATP
phosphatidylserine
outsourcing
intranuclosomal degradation of
DNA
Phagocyte
TGF!, TGF"
TRAIL R2
Caspase 1
activated
effector
Cadherine E - Cathenine !
Author: Pierre Fauquenot
Control of the Apoptosis Mecanisms
Pierre.FAUQUENOT@etu.lasalle-beauvais.fr