DrugDeliverySystem

Teuku NandaSaifullah Sulaiman

Laboratorium Teknologi Farmasi Laboratorium Teknologi Farmasi
Fakultas Farmasi UGM
Definisi Definisi
A drug delivery system (DDS) is defined as a Adrugdeliverysystem(DDS)isdefinedasa
formulationoradevicethatenablesthe
introduction of a therapeutic substance in the introductionofatherapeuticsubstanceinthe
bodyandimprovesitsefficacyandsafetyby
controlling the rate time and place of release controllingtherate,time,andplaceofrelease
ofdrugsinthebody.
This process includes the administration of the Thisprocessincludestheadministrationofthe
therapeuticproduct,thereleaseoftheactive
ingredients by the product and the ubsequent ingredientsbytheproduct,andtheubsequent
transportoftheactiveingredientsacrossthe
biological membranes to the site of action biologicalmembranestothesiteofaction.
Drug delivery system is an interface between
the patient and the drug. It may be a
formulation of the drug to administer it for a
therapeutic purpose or a device used to
deliver the drug.
This distinction between the drug and the This distinction between the drug and the
device is important, as it is the criterion for
regulatory control of the delivery system by regulatory control of the delivery system by
the drug or medicine control agency.
d i i i t d d i t th h b d f device is introduced into the human body for
purposes other than drug administration, such
th ti ff t b h i l d lit as therapeutic effect by a physical modality or
a drug may be incorporated into the device for
ti li ti lti f th preventing complications resulting from the
device, it is regulated strictly as a device.
Thereisawidespectrumbetweendrugsand
devices,andtheallocationtooneortheother
categoryisdecidedonacasebycasebasis.
DrugDeliveryRoutes
Categories of Pharmaceutical Dosage Forms
FIRST TIER CATEGORY DELIVERY ROUTE [i.e. based on tissues to which active delivered]
Mucosal Membranes
Skin surface
IV
IM
etc
SC
Gastro-intestinal Tract
lungs
Tissues or Body
Fluids
[by injection]
l
otic
i l
etc
[by injection]
nasal
otic
ophth-
vaginal
oral
topical
dermal
trans-
ophth-
rectal
topical
almic
urethral
oro-
phary
ngeal
6 6
7
4 3
8 9
4
7
6
10 5
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SECOND TIER CATEGORY DOSAGE FORM [i.e. based on the general type of dosage form]
[ Indicates page number of
second tier]
[Dermal]
Categories of Pharmaceutical Dosage Forms
Skin surface
[NOTE: May preface titles with topical , e.g. Topical cream ]
topical
SECOND TIER CATEGORY DOSAGE FORM [i.e. based on the general type of dosage form]
8
SECOND TIER CATEGORY DOSAGE FORM [i.e. based on the general type of dosage form]
solids
semi-solids
patches
powders
liquids
collodions
solutions
ointments
plasters
aerosols
suspensions
films
foams
pastes
gauzes
emulsions
w/o
creams
tapes
/
gels
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THIRD TIER CATEGORY TYPE OF RELEASE [i.e. based on the RELEASE PATTERN OF THE ACTIVE]
o/w
gels
sticks
Categories of Pharmaceutical Dosage Forms
[possible common Third Tier categorization]
THIRD TIER CATEGORY TYPE OF RELEASE [i.e. based on the RELEASE PATTERN OF THE ACTIVE]
Conventional release
Modified release
(immediate release)
*
Extended release
Delayed release
[Slower rate]
[Delayed onset]
P l til l
Targeted release
[Delayed onset]
[Specific organ/tissue]
*Use of conventional release is encouraged.
The termimmediate has been widely used in place of
the less misleading and more appropriate term
conventional with reference to dosage form
nomenclature
Orally disintegrating
Pulsatile release
[Faster rate than conventional]
[Fractions released at time intervals]
nomenclature.
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Orally dispersing
[Faster rate than conventional]
New Desain Drug Delivery NewDesainDrugDelivery
SustainedReleaseOralDosageForm
SustainedReleaseInjectableDosageForms
SustainedReleaseTopicalDosageForms
Implants And Iuds ImplantsAndIuds
TransdermalDrugDeliverySystem(TDDS)
Targeted Delivery Systems TargetedDeliverySystems
Liposomes
Nanoparticles
Polymers
MonoclonalAntibodies
TransmucosalDrugDeliverySystems
InhalationSystems
BuccalDelivery
RectalDelivery
VaginalDelivery
OcularDelivery
Others
Vaccines
PolyclonalAntibodies
ConsiderableadvanceshaveoccurredinDDS
withinthepastdecade.Extendedrelease,
controlledrelease,andonceadaymedications
il bl f l l d d areavailableforseveralcommonlyuseddrugs.
Global vaccine programs are close to becoming a
li i h h f l l reality with the use of oral, transmucosal,
transcutaneous, and needleless vaccination.
Considerableadvanceshavebeenmadeingene
therapyanddeliveryofproteintherapeutics.
Many improvements in cancer treatment can
be attributed to novel drug delivery
technologies.
New drug delivery systems will develop during
the next decade by interdisciplinary
collaboration of material scientists, engineers,
biologists, and pharmaceutical scientists.
Progress in microelectronics and Progress in microelectronics and
nanotechnology is revolutionalizing drug
delivery delivery.