AUTONOMICS

Para Pre Para Post Sympa Pre Sympa

Post
Sympa
Post
(Sweat
Glands,
Arrector
Pili,
Cutaneous
B!
"eceptors Nicotinic Muscarinic Nicotinic Noradrenerg
ic
Muscarinic
NTs Ach Ach Ach NE Ach
#en$t% Long Short Short Long Long
Acetylcholine
Acetyl CoA Acetate + Choline (thru Acetyl Transferase) Ach (degraded by
acetylcholinesterases)
Norepinephrine
Phenylalanine (1) Tyrosine () L!AA "#PA ($) "o%a&ine (') Nore%ine%hrine
(() E%ine%hrine
(1) Phenylalanine hydro)ylase
() Tyrosine *ydro)ylase
($) Aro&atic L!AA "#PA "ecarbo)ylase
(') "o%a&ine hydro)ylase
(() Phenylethanola&ine N!&ethyl Transferase
Alpha 1 (Postsyna%tic + E)citatory)
! ,ascular s&ooth &uscle- ./ s&ooth &uscle- li,er
! intestinal s&ooth &uscle
! heart
Alpha 2 (Presyna%tic + 0eedbac1 inhibition on release of NE)
! %ancreatic islets (b cells)
! %latelets (aggre)
! ,ascular s&ooth (contractin)
Beta 1 (E)citatory to 0at2*eart)
! heart
! 3. cells (rennin)
Beta 2 (4nhibitory to S&ooth Musc2.lands)
! S&ooth &uscle (,asc- bronchial- .4- ./- uterus)
! S1eletal Msucle (glycogenesis- u%ta1e of 5)
! Li,er
Beta 3
! adi%ose tissue
Potential Ways to afect Autonomic Neurotransmission
Synthesis:
! %recursors
! synthesis en6y&es
Storage
! %rotects fro& degradation
! 7uantal release
Release
! agents could interfere 8ith or enhance the release of NT
Reuptake
Binding and actiation o! receptor
Breakdo"n
#opamine
! both al%ha and beta
! Metoclo%ra&ide + do%a anta " CT9 area %ostre&a
! "A1 + :enal ;asc 4nc /#
! "o%e)a&ine + "A1 Ago + beta agon
Nicotnic (N& or Nn)
$uscarinic
M1 + autono&ic ganglia and CNS
M + Su%ra,entricular %arts of the heart
M$ + S&ooth Musc and .lands- ;asodilation due to interaction 8ith endothelial cells
(4nc Ca N#S N# "i<usion Acit,ation of .uanylate Cyclase ;asc :ela)ation)
=Endotheliu& should be intact