MillionaireProject

ByJackMuffin,JasonFranks,PeterHunt,KyleJones,RonanShaffer

Unmetneed:Thenaturalcureforcancerthroughproteinsincancerouscells.

ProjectIdea:TouseTIC10asanaturaltumorresistor.

Materialsneeded:
lab(needsqfeet)
tumors
mice
50mgofTIC10$350
100microgramsofactivehumanTRAILprotein$198
scientists
employees

TRAILstandsforTumornecrosisfactorrelatedapoptosisinducingligandorApo2ligand.

BackgroundonTRAIL
TRAILisamemberofatumorkillingmoleculefamilythatsjobistoinitiateapoptoticsuicide.
TRAILisauniquemoleculebecauseitkillsonlytransformedcells,notnormalcells.TRAILis
notcompletelyeffectivebecausesometumorshavedevelopedTRAILresistance.Apoptosis
producescellfragmentscalledapoptosisbodiesthatphagocyticcellsengulfandquicklyremove
thecontentsofthecell.

Problem
WhydosometumorstodevelopTRAILresistance?

Solution
Asamateursinthisareaofscience,Ibelievethatwewouldnotbeabletofigureoutwhysome
tumorsdevelopresistancetotheTRAILprotein.Whatwecandoiscreatealaboratorywhere
wegivethebestscientiststheopportunitytosolvethisproblem.IDEACombinearesistance
proteinwiththeTRAILprotein.

FacilitiesneededtomakeMaterials.
lab(needsqfeet)

Estimatedcostofdevelopment

Howmanyunitsshouldbemadeforthemarket
Asmanyaspossible.

Timeline(productionandtimetodevelopproduct)

Market(whowillbebuyingthis)
Anybodywhohascancerwillbebuyingourproduct.

Bibliography
http://www.nature.com/onc/journal/v22/n53/full/1207232a.html