http://www.prnewswire.

com/news-releases/survey-of-pap-and-paracetamol-in-asia-pa
cific-137405843.html
Asia consumes 65,400 tonnes of paracetamolhalf of the global output of 2010
Macdonald, G. (2009). Europes last paracetamol plant closes its doors. in-PharmaT
echnologist.com. Retrieved from http://www.in-pharmatechnologist.com
Chassany, A.S. (2008). Rhodia Shuts Europes Last Paracetamol Plant as China Preva
ils. Bloomberg.com. Retrieved from http://www.bloomberg.com/apps/news?pid=newsar
chive&sid=az9ShNouwC8U
"We detect more quality problems during our inspections in China and India than
in France, even if theyre for the most part minor."
China and India produce about 115,000 ton of paracetamol per year (70% of global
market)
Global market: est 165,000 ton/year
Chinas drugmaking industry had estimated sales of $4.4 billion in 2005 and may gr
ow 18 percent annually to $9.9 billion by 2010, estimates Jinsong Du, an analyst
at Credit Suisse in Hong Kong. India ranks third after Italy, Du said.
Covidien Ltd. - world's largest paracetamol maker: 30,000 ton/year
Rhodia: Roussillon - 8,000 ton/year, Wuxi - 7,000 ton/year
Anhui Bengbu Bayi Chemical Industry Co. Ltd. - 20,000 ton/year
Dal Pan, G.J. (2009). Acetaminophen: Background and Overview. In U.S. Food and D
rug Administration. Retrieved from http://www.fda.gov/downloads/AdvisoryCommitte
es/CommitteesMeetingMaterials/Drugs/DrugSafetyandRiskManagementAdvisoryCommittee
/UCM175767.pdf
Overall acetaminophen market: 28% growth from 2004 to 2008
24.6 billion doses/2.6 USD billion in sales in 2008
Nearly 80% of entire market is over-the-counter (OTC) product
China Chemicals Market (2008). Benchmarking on PAP and Paracetamol Production in
China (2nd ed.). Guangzhou: CCM Information Science and Technology Co., Ltd.
Catalytic hydrogenation of nitrobenzene production cost: 3212 - 3504 USD/ton
Typical selling price: 4000 USD/ton
Characteristics: Low pollution, high yield, high quality of product, hard to ope
rate, high cost in catalyst
Liaoning Huludao JinhuaFine Chemical Co., Ltd. adopted this technology, but stop
ped in 2004