PROBLEME DE COMBATERE A TUBERCULOZE]I Mihaela Tanasescu’, (tistian Didilescu2, Constantin Marica? Prezent si perspective jn diagnosticul rapid molecular al tuberculozei si al MDR-TB (prima parte) Present and expectations for rapid ‘molecular diagnosis ofT8 and MORTB Tuberculosis sillone ofthe diseases wth amajor ‘medica and social impact andin terms of ely diagnosis {wich would imply afar treatment and established ‘atthe time dfleutesrelatedtothe delay baci ‘sation mcr decreased suscepti testing ‘methods to anttubercuoss drugs, ackofmethodsfor “ferentiation of, Tuberculosis complexgermsefnon TS ‘Mycobactera, may have impertanclnicalimplations. Traonal testing of ant 8 drug susepoblity on solid LenensteinJensen medium gold standard oriquid ‘media canny be performed sing grown samples. Determining the time takes up to 42 dyson sold media ‘and 12 dys fer iu media. Far MOR /XOR TB cases bsoltely eset reduce the detection time inthese ‘asesprovetheruselunes rapid diagnstc methods. ‘Automatic tein quid medium, molecular ybridzaton methods arecuentyecommended bythecurent WHO guidelines Rapid diagnosis of MOR-TB s extremely useful for the early establishment ofan elective raiment talored mre accurately onthe spectrum of sensi ofthe resistant stan hus reducing the nskof developing addtional esstanceto other , Unversapatern of po gene mute as amon rstdregras tnt slates of 40, Supply P Lesa ssovine Eker KvanSolngen Loe Aciomated nigh hauohout genotyping for uty 9 903 epeemslony “ae vomes rage hPlomores ic ana svar - Use ates Pe ta ori Yorrapd aetna op ana caisiestaee 42, Van Prieren Lc Dagnoss of uberculoibases onthe two specie ‘Seige: ESAT 1 C291, Onc and dogma abate mmansisy Goon Tey sco, ‘Eene WisleatnSrgsniasvon 2508 tp uhalaencae Dubleasons/ 2008/ s799)59207, ely Supt TB (H/XOR-B):2010 rca an response WHOPHTM/T8/2005. SBN 45: Wo, Reneonmeral cure and dug-sucept ly testing methods ater 20 orem, 138 Vol. 62, Nr. 3, 2013 Reclama PN 62(3)0106 + = Reclama PN 62(3)0105 + i’