ii

LIST OF TABLES
Table no

Name of the table

Pages

Typical properties of HPMC

38

Apparent viscosities of HPMC

39

list of ingredients with their source

50

List of equipments with model/make

51

Formulations Containing HPMC K100M ,HPMC K15M

54

Formulations Containing HPMC K100M,HPMC K15M,Sodium

CMC, Ghatti gum

55

Standard values of angle of repose ()

56

Flow property and corresponding Carrs index & Hausner ratio

57

Limits of weight variation

59

10

Absorbance of Metaprolol Succinate in 0.1N HCL

65

11

Absorbance of Metaprolol Succinate in 6.8 pH phosphate buffer

66

12

FTIR peak positions (cm-1) and assignments for Metoprolol succinate

drug and its combinations with Excipients

67

13

Blended characteristics of Metoprolol succinate extended

formulation.

70

14

Evaluation of tablet properties

72

15

Cumulative percentage drug release of F1, F2, F3, F4 formulations

74

16

Cumulative % drug release of F5, F6, F7, F8, F9, F10, F11

75

17

Data for release kinetics of all formulations of Metoprolol succinate

76

iii
LIST OF FIGURES
Fig.no

Figures

Pages

A hypothetical plasma concentration time profile

from accepted multiple and single doses of controlled
and sustained delivery formulations.

Schematic image of diffusion controlled drug release

reservoir

Systematic diagram of diffusion controlled drug

release matrix system

Drug delivery from surrounding pH sensitive release

systems

11

Parameters definitions for swellable soluble matrix

13

Structure of Metoprolol succinate

34

Structure of Hydroxyl propyl methyl cellulose

37

Structure of Povidone

40

Structure of Microcrystalline cellulose

41

10

Structure of Magnesium Stearate

44

11

Structure of Sodium carboxy methyl cellulose

45

12

Structure of Ghatti Gum

48

13

Calibration curve of Metaprolol Succinate in 0.1N

HCl

65

14

Calibration curve of Metoprolol Succinate in 6.8PH

Phosphate buffer

66

15

FTIR spectra of pure Metoprolol Succinate

68

16

FTIR spectra of Metoprolol Succinte, HPMC K15M

68

17

FTIR spectra of Metoprolol Succinte & polymer

69

18

FTIR spectra of Optimized formulation

69

19

Cumulative % drug release of formulations F1, F2,

F3, and F4

74

20

Cumulative % drug release of preparations F5, F6,

F7, F8, F9, F10, F11

75

21

Drug release kinetics plots for Optimized

formulation F11

77