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http://www.ncbi.nlm.nih.gov/pubmed/22757707

Abstract

J Food Sci. 2012 Jul;77(7):H147-52. doi: 10.1111/j.1750-3841.2012.02748.x.

The hypoglycemic effects of American red ginseng (Panax quinquefolius L.)

on a diabetic mouse model.
Yoo KM1, Lee C, Lo YM, Moon B.

Author information
Abstract
American ginseng (Panax quinquefolius L.) root health benefits include treatment of type 2 diabetes and this
study evaluated the hypoglycemic effects of American red ginseng (ARG). ARG roots have increased
bioactive phenolic contents, such as cinnamic acid and ferulic acid during the steaming process. The
antihyperglycemic effects of methanol fraction extract of ARG, ferulic acid, and cinnamic acid were
examined using a type 2 diabetic mouse model. The ARG treated group presented relatively lower blood
glucose levels than the control group (P < 0.05). In addition, the glycogen and high density lipoprotein (HDL)
contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL)
concentration were significantly decreased in the ARG treated group. The groups treated with ferulic and
cinnamic acids showed similar effects as those found in the ARG treated group. Thus, it is suggested that
ARG roots, ferulic acid, and cinnamic acid have hypoglycemic effects in an animal model.
PRACTICAL APPLICATION: This study was conducted to elucidate the hypoglycemic effects of American
red ginseng (ARG) using a type 2 diabetic mouse model. ARG showed an enhanced antioxidant capacity
and higher antihyperglycemia effect. The glycogen and high density lipoprotein (HDL) contents were
significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration
were significantly decreased in the ARG treated group. It is suggested that ARG has a potential to be used
for human diabetic treatment.
2012 Institute of Food Technologists
PMID: 22757707 [PubMed - indexed for MEDLINE]

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http://www.ncbi.nlm.nih.gov/pubmed/22757707

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