{bmg tenn te nse "see snd arel ar a vach te tre aan ag | ebony shel Th rbest try nbsanha o aey {ban nd branch slo ac any, wich Elsevies Kiersranbaum: Hi and Call Biol hha mean ep nance ‘aot woe munes acernacet nant {Steet Gove hee rd oats hr ‘mo eteurmca oes taarean els ‘Warne anne orgy secre ogra se Repent anaes ghee mn rtecndeeblar aptaon weathay ata 1 Introduction to Pathology 22 - www.studentconsult. comrr sting predamites) 4 _ Sri raneton neat ames eno ncreasing gh rete crarasn Eocermic aoa ae: oa, 3 _ Pesidus poibosomes | Proseytheoblast Seo Figure 6.18, _— Basophilic erythwablast ‘Alage oot (120 16pm in hameler) wih intensely basophil ooplasm a an ‘nation ofa ge rube of poyraosomes The nudes conan coarsely clumped ‘tromatn and nucieol are nat usualy seen This ell ean divide by mattis. Basopic eryrabass dere rom te proryecbast. _Polychromatophiic erythroblasts. “These cats may ‘angen damatar Hort 15 jar. The mins es dere {Gromatn paces separated by ight ares. No nucleolus is visible The sinktorray staangh ‘No call division kes place aller the polychrome eryhvobist, ‘This as apprnnaty 6 10 en in dared Te eyopae pak, mc te ‘sare as he retcancyte These cls hae an extremely dense (nati), ‘sated rucieus,Orthochromatc eryihoblasts are postmitotic. ‘The rarsitonforetcJocye preceded bythe extuson o hn condensed nei {thalcaries wiht rim of logs. The etude ruceusis ene by 2 ‘macrophage. | Raticuioyte 1 ‘These anucleated cls measure aprcanatey 7 08 ym dame The ‘jtoplacm pinkie tr rthocnomatc eytcblas. in eplarpreparaions, ‘ese ots eppear dental o mature entoctes ih supe ssi, sich 3 mahylone blue or creel Dt, kaetos ra nat ot ‘alyboromes became se, etculoyis remain in febone marrow or 1 2day an han are released ‘nt me perpheral Blood Follow I day of ereulaber rete matt into eyhrooies.Eeyoocye sre crtabrdt co nebo Treycortn temag ii srertali bat amees Exes estoy siege aa artnet ie. corm ne ctaass Entry tw hecan ‘red bhood cals ate phagarytosed by macrochagas inthe lver ant spiben ‘A 9 eng a) ra yr en NAM, comedy ease Jercon lv: baskets oregon Bye cece snc Wrath eal etn sae ad ase hn Scape edaoy meget or weche wae he tod folate heron a soachneat efST-HSC Polychromatic Orthochromatic ‘erythroblast erythroblast: Loss of mitochondria J ribosomes a Erythrocyte, ) of nucleus Proerythroblast Basophilic Reticulocyte CFU-E erythroblast Goran & Bovipaen: Medical Physiology, 2nd Edition, fe 1008. ‘nmr of Evie, Ye, lights reseed.‘Low 0, tension Orypen dependent roy hycrntase (sensor in onl intstia ce) sina and activates the entropoetin gene lence Déxvinropoietin EPO) —- Erythropoietin and the JAK-STAT signaling pathway GH Exythropoietn (EPO), posed by inerstal Cells in the real cortex, s transported othe bone ‘marow byte ood creation, BD in re bore marrow, EPO binds tothe dimerizes erythropoletin receptor, present in ety stages the erytiroid CFU progeny, andres rng ot cylssie STAT 5 (al tansduers and achat of |ranscription 5) protein to JAK2 (Janus kinase 2), a ‘tyrosine kinase bound to the intracellular domain of the receioe, EB Tie inactive (nonphosphonfate) form of STATS contains an SH2 (Src homology 2) domain, STAT 5 is ‘ected JAK ard ies tous he SH2 domain. STAT 5 becomes active (phosphorylated) and ‘homodimenzes. GB Tre phosphoryiated STAT 5 homodimer translocaes ino the naces. GD Airervincing to OVA, the phosphonate STAT 5 moder actates he ranscrpton of pectic genes reaped or erytropaiess.(granulocyte-macrophage ( Generates the B call progeny in the bone marrow and T cell ‘rogenisin ine tyros. Ty ae dss n cea Chale 40, InmoreLymptate Sse‘Boron & Boulpaen: reeical Pyology, 2nd Eaton. [Conyngnt © 2008 ny Souncers en Mgnt of Elsewse, Enc A ight served20700 & Boulpacp: Medial Paysclogy. 2nd Eden. "6 2008. fm morrt of Sse, eA Apoferritin bound to ) the transferrin receptor is recycled back to the plasma ‘membrane. At a neutral pH, apotertin dissociates from EB inthe endosomal the transferrin receptor. ‘Compartment, the low pH Fes