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The researchers found that interferon gamma kept the herpes virus dormant, but
when the immune system responded to a helminth infection, the virus would
reactivate.
In co-operation with researchers from Washington University in St. Louis, MO,
Renne and his UF colleagues investigated how human herpes virus 8 - a herpes
virus linked to the Kaposi's sarcoma cancer - reactivates. They publish their
findings in the journal Science.
Working first with a mouse model, and then replicating their findings in human
subjects, the team found that after initial infection, the protein interferon gamma
kept the virus dormant in the body.
However, the effect of the interferon gamma was cancelled out following an
infection from a helminth worm - a common parasite in sub-Saharan Africa, where
Kaposi's sarcoma is also common.
The researchers observed that another protein called interleukin 4 was
released by the immune system to deal with the helminth, but this blocked the
interferon gamma function and also activated the replication function of the
herpes virus.
Replication of the virus causes new cells to be infected, increasing the chances that
a cancerous tumor will form.
Senior author Dr. Herbert W. Virgin IV, of Washington University, says:
"The fact that the virus can 'sense' the immune reaction
to a worm and respond by reactivating is a remarkable
example of co-evolution.
We think other interactions between multiple infectious
agents and the immune system will be discovered over
time that we will view as similarly sophisticated or maybe
even devious. Understanding these interactions will help
us survive in a complex microbial world."
Earlier this week, Medical News Today reported on research from scientists at the
University of Montreal in Canada who suggest that a small molecule found in the
urine of pregnant women blocks the growth of Kaposi's sarcoma, as well as a
variety of other cancers. The molecule is a metabolite that is a product of the
pregnancy hormone human chorionic gonadotropin.
In 2013, we also reported on a study that suggested a type of nanoparticle could be
used to deliver vaccines that protect against HIV, human papilloma virus and
herpes, as well as flu and other respiratory diseases.
Written by David McNamee
Copyright: Medical News Today
Not to be reproduced without permission.