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    liquid handling platforms comparison

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    liquid handling platforms comparison

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    4 views4 pages

    Chai European Pharmaceutical Review December 2013

    Uploaded by

    dssadkjl
    liquid handling platforms comparison

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 4
    Liquid handling devices in drug discovery: when, what, why? ‘Sergio C. Chal, AsliN. Goktug and Taosheng Chen eghThoustpu Scmening Cre Septet of hari! Hany and Therap tk Ste Cer eve Liquid handlers are ubiquitous and essential tools in every aspect of the drug discovery arena. Innovations in the past few decades resulted ina sizeable array of devices. With so many choices, itis important to identify appropriate instrumentation for ‘a particular screening strategy, which should be based on unique capabilities and imitations Intense advances in the design of liquid touchthesuroce of thedestnatoncontsineror gap separating both fluids, In other handling devices have broadened the solution’ Based onthe delivery mechanism, _stuntions, ony aris dxpiaced to drive ‘capabilities to screen larger collections of they nchise tip, pezoelectic, solenoid: nd baud movement compounds ata ferer pace with increased acousictbzed devices in adation to persaic ® Apintool device cond of caste with relabity and efcency. Teseinnovaton ft pumpsandpin-ranste an array of floating stainless stee! pins towards minatrsation alae parttoveduce © The peristaltic pump ' used for bulk The end of the pins that isn contact ‘cost and incase throughput A wide selection reagent dispensing, where continuous with the reagent can follow various offic handlershavebeen developed or evry fluid motion i created in tubing com- pattems cuding soli, grooved o sorted aspect of drug discovery, which incorporate rested by rotating roles surfaces, An optional hysrophobi coating diferent technologies foresee functions |s mended to reduce non speci binding [Ahough this segment focuses on insu wa wide selection of fluid handlers Soluions are transfered hough a combs ‘mentation relevant tothe screening of small gs been developed for every aspect nation of capillary action and surface ‘organic molecules the perspectives presented ‘of drug discovery” tension, with the volume being highly herein can be valuable In the handling of dependent on contact surfaces and zu ‘lgonuceotidesorbologles, (© Tpased wansfer devices can incorporate an properties LUquis hanes can bebrosdy categorsed fixed o changeable (eispossble) tips @ The plezoclecti dispenser delivers sok as bulk dispensers or transfer devices, assembledin?,.€-or8channelexpancable ons as multiple tiny drops of deine ie depending an whether large volumes of 3 liquid handling arms in adition to 96 or A piezoelectric crystal collar is bound Single regent are beng dstrbuted or smaller __384-channel heads. They function based to 2 caplary made of quartz or ste quantities are being vansered!Inadétion, on an air csplacement mechanism; in which s fled withthe dested reagent. ‘these incvumants can follow two dispensing some cates the ctor orange plunger _After applying valtage, the piazolecte modes: contact or noncontact depending on pulls system liquid from the pipette _element contacts electing fine drops wether the ido be ransered sllowedto tubing Lo aspiate the samp, withan air tweughaneniice athe end of he capillary European Pharmaceutical Review. ‘one curapeanpharmaceuairevw com 7 ‘oue sue 203 LABORATORY AUTOMATION Thoushpt Foe core Benge Se a fanseronninsesohne ge Secon cour fies ny conten Feesemer TaaRc Gang RTE RT TGA RTT Taga Tenn Tuarances Crtesasomaton Agence Atte ntgrte sacarsorncusates “snd nepaton ‘smamtovter Bomex ame Tow ‘Senora reer A tctoneniy “Aglare “TIP Labech mosqute HIS agi Teng mdpccaon Tapco Sehapydeeakten “Coney 1 Solenoibated devices make use of slen oidvalestoochdethe low of presurced quid Elec curent atuates the valves slowing the slation to flow as doplts oF 1 Acoustic droplet ejection (ADE) adopts acoustic energy to propel droplets froma source plate to any wel inthe destina ‘on pate, which remains in an inverted postion Specalsd ib wars requtes for ths technology. Many ofthe varouskinde ofa handles can bbe utllsed az 2 standalone component, functioning independenty from any other ‘equipment. However, these devices re normaly integrated int large stations that ‘acitate routine tases, reduce human inter vention, increase throughput and allow for multitasking in 2 single run (Table 1) ‘These systems can range from compact workstations dedicated for apartcula purpose, tw fully-automated robotic decks capable of performing an innumerable combination fake Broadly speaking, ene can consider ‘we major kinds of solutions or suspensions {at partake in a ypical screening endeav ur: biological reagents and compounds to be tested. They may require devices ith eitfering mechanisms, a the ltr is notmaly delves a small quanttie, while ‘the biological mires are typlelyeepensed inbux, Se Mecnien Fancioaly Por Ge Greyock Sconscolueromclverange Selene oe nd oe decennial: wares nue thisdhowsngwarngaahie ‘Nitngepexontte ioe Conacieonc musta Samak Revelte ace ane Te ape STE Sperplanacionand| Restle netoom acu Biotin pbepsicoadwsoneiate Peres Keasicaepaaecon — Nenoraatiqnavenser Samper Taraetoricaivemnps Speci ABE TES Dyasnute ray Romnoesmumeranierromanwel “sumer ‘panotnens! -Aeromea geek Netra toy eto ue maninen pate European Pharmaceutical Review ‘ue ues 205 7% LABORATORY AUTOMATION ‘Transfer of biological reagents Celis proteins oligonucleotide or other logical components that ‘comprise the aes are allocated uniformly throughout the sesay plate in column or row-wise fzhion, for which buleresgent dispensers ae used Pesta pumps or presursed-dspensers are ‘commonly employed, which ae capable of delivering varlable ‘volumes from submcrltreto irl range with high speed and

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