Sistemul complement fn ani 1980, Jules Bore, cert a Insti Pasa ip Pais, dtcopert 8 antisera de oi et Vio cholerae ei ea Ducted ot eat pede acivinea baci, Dae nc exe as er ress dawn animal nena (So un et ‘ae u cane areal apace deuce bacterile reaare. Conclui ui Bore, pees sala » fost wea ch atin Dactertica neces dou substan fete anceps pei pet Bictera respect cepbll seat robs ds ‘aloes cmp sens lacldi,pe care denarii ‘Abst temen pu apes in Cv a ma i, Pel Elec fice o erie de expentneate ine Is Ren prope terme de icorpleent pest dei oaiviates soi ete rine competes afin ope, [stalin despre ssenolcomplemeat crepe un asa aie de 30 de mules obi smembrenare. Uncle a It ‘cv, assem danumit in exe" sot eu cel al xegulri ibaa ale oleae pari a aa, ‘aa sisera activa. compas complement vor ncepe al st reactionsze un cu cela, ceva cv canis il Ia see de cesecie boogie ‘ise complement an aoneara sigur. De aseeea, nafs de fp stare complemen pote apre fn mad sponte (a vee scat) fa ier complexelor ime, pate declan de cae pas (praesent de engae). ae ene ‘nde ee Cli Campus C3, cu gretate mat de 195 kDa, Format dn dou fap psipepiie ef erent campus principal oa itepui complemen Exe past ia plas ie onset de aprovmaty 1~ 2 gi Ct aariae une fa de meal ce [ea 0 modieare ps rstayonala pecan tate gupates cx! COOH) ata de gam exe sulfide SH) aur ‘de cen din matin vetoes fermeao leur inter ese. Acasa leer ee metab pip lectolic acecae 4 elecrn) catbnil (C°=0) al gain! exe snc Ip sae! Yor gril nce {ecto donc) agjucets cay at ‘pire crn amino ale uror rte aw ghee. Accs race pemit elaine se lege cna she race i een nears pin Ce C3 e pot eg ale de compas. ‘Legitura ines doer este suscep ao Mola lu, ca umave ast api condund no forma activa aC Tn nod nota, ‘noxganisn, acox mecanssm sist gener continu nt anit ct i de) aot. ‘Unal ecaisn de acivare copa C3 te seal elvis proteolec. Tee ul fagmen mic i ce terminal al ful ‘(dec oenina pum eonvertzd C3) cone a moder conformational casa eaten toes fote Hb Activated (3b Aces devine un sus deiner exem de ssceptbilI aciuea grupo lero. doaare(C3b"). Majoniatesmaleclloe de (Cap neraconeaza cu aps da un pose! mic infracfonssl eu pretene sa lick dt dts vein stout de activate, De ‘ems ce envetazeleC3 stp geerl genera cat vo eset aa) pesopffe rans sa nivel compel ae, ‘eeasta sean cs cepeorea Cw ae oe neal de oclioe,‘Compusl C4 prosn de asemeoes oles inet ios, aca unel seve lt hoologe cu cea din 3. Exist de isetpr de (CLIC s CA, ete do out gene aie nnd n cant MHC, ests sete, C84 prefers lege fa rp smi ete tein, oan grup dis, op o& CA se ag specs gran iol le exer candice I rps etree Hider leg tise a sompuculi C3 nav dete molculele despite fn abundnf conde I formar compas CS C30). Aces campus ai th pezeja Mg" lead aco B. cee ce condce Ia expuneea ura ss al acestlapenta enna D. "nga procs al complement care resin 9 seit esinatis (sen extort) fr fe nreara macs I, Factors D liven facto Bn agent Ba mie Cee va elvan feaent mare, Bb, care ease aga C3, C3 frmeard Tpreunao convertaza C3, capi sd scinders prod C3 ip agmentele Ca mi} 9 C3b (ar) In conde a ovgnismal muse ‘nthe un stige, aca envertzh rmne sci iva cna cn atl eh iv nar Cee es, Caps (Cap cae ens or rane aed lor esl oe rola, se vols sat noe le sll. Ace supe sa ‘onside -eposcve™ nase el, C3 pare a afb o anit de legare mal ate pen facto H dec peat ft 3. ‘tars fcr Hw coven a factor Io rains relate) concen cian scvenals corps Ca nl se (Git cera Gagmentl C3 ndnind fragmenta are Xb. Ace eX oy cms ia ind nepal nl pce la acca SiemallClivarea In comiuare a 1C3® condce La fapert tot ma mil: C3e st Cg. ape Cd fl C3g (ven Relea stem complemen. “oj comput cae paca Iya oer sept ga a membrane, manera ders eit Al, C3, 1C35, C3ds, C3 sunt opvonie se sstemolel camponent, recaoscule de ciue foxpor al emul compbnt (zi Recep a sbtebul compere). th ee Cell membrane —_—— 7 ~ Gall membra te _ R R ° E, 6 o-c SH SH; O-C SH a waste gtaiG z& 8 ao CRI or MCP cian ECdg | Factor 2 eae Bound C3b Clea alternativa Acoust cle do acre nu neces prosnt anticalr 8 aseea eum cramer exch al aps nespenice, Factor ate pot enti! ia dsr ci alematve de acivars wel campenet sat rectal abel ees Pataged sl grieae de origine miro Now palngenl Tan Gram negative Cone aan TS ale bacirlor Gas Cempeceinube cu eG gp eT Baer ra pote Fara din veri de cob ‘Acid iho din peril ECE Ga PORTE Ente elege (eput, ae SRE) Pee cele ungel aca Pliner alo lexan sla) acl vison elle fee al Carb py gue, nin) ‘Uaeie celle were Ra) Pasi pasa *Mecaismul pein ae TEA pe JOC lea ToBI Se Taco OT ES{Compu C3 care pein irl ent, spot e pote egal supra antigen, dar fl spree elon ogists ‘Menbranele seirau un cont ceseut de acid sic da poses ale mecanse ve reglarea seul complet) cae le peri ‘macivana rapids conpuplor Cb. In Schinb, pe spate stew Cie vane acto pails et lung de tp fs. no ‘mares Mg’ depended, pot lega conpusul serie B Acca Tegare determing cxpunre inl sus al factor B eae repress Suara de ate al facto D. Clare B deere D cence a elven fagmenisil mi Bs, inp ce agent mare ‘mine alae Is C39 fomeac3 impr compen C3bBD cate pci activi nematic ~convertaza C3 sci lena. Aceh ona ate operand etna de ual nine, da, tor compesull aa proper” poate ft subia pan a 30 de ‘Neen converte sabia pte avon supra ue ol molecule atigzte de C3. Pin seas Se ange a genesatea una una record de molecule C30 (219 mcevl pot depase pe suprafata cell nm patn é Sint 6 pane ln molecule Cab generate se agen la cnnertara C39 genre compennl C3HBUCAD. Componesal Cb n-nzimatic a aces complex se aageze [a compusul C3 le companetl Bb hiroieaet compos CS at gl sina fragmenta mie CSa(o arstoxing, cate va cbr hse) campus snare C3h. ceca se fag ta Supa respec Ya aug apo cs CS, zcangnd un boa set de oven care Yor candace a ermarea aa ruil Complex ce Alae Mersranar"(MAC)- Caen each Cale case eacivre a carpet Tepe rin fommarea voplenek aerator, IM, rut subelased 0 lg, Is G3) gn aeato nlmanotogll por ava acest ee ‘paren tticorull a atge nds dc cnfertionae lil pial Fea males de IgM, cate vr expure un sus de egare pet comps Ch. Ch estou complex macroetecular src format dno leu Ci ite 2 oe de Clr ls stabilization de Ca {Cig este fomat ain 18 tur popeecce eae se ssoclrs en's Toma 6 bse oem demi ele eu'9 STucnFa colagen ike \Vrtrile bratsloe conse denen globular legare pests damenile Cj2 ale moleuser e ancerp de last G sau Ci ale relecllor de sicrp de cst yoy cre din motes Clr Cs canine cite wr meni aati, cu avi ersimatic en domeniy de ineracune,cre eed Tegra cate le sas pss cu Cla CS see liber, CLC se arajest fea ere! S. Ci so legate la Cia, fora fe‘loca moleuls Cl bul sage, cu sto espaelor sale soblae, cel pin 2 ss Fe pou a intreiones fe stabl Anu ‘nd IgM pean este leg la wlgen sat pe o spat cll Ys aiapul Va avea a caiigurate de “ead” staple ‘onfigcatin'). nicer gM eal ee 0 fot pun, Te eae stasis de lgare la Clq Sut expise. Din aes mot IgM ‘ral sngur8 (eg pete activa cascada coment Pedeatt pane, molecule de 2G conn doar ua sigur situs do ogre la Cg anv domeniuhl Cl Fe. asf et ogra ferns oste stir drar dict 2 ok de gG se ise fa tay mal mes de 3040 am ua de elle sopra tsa xn empl, faring 2 isu de lear penis Clq. Aces dient i stratum aM ft de cea a IgG exp de eo sing oct de IgM ete sileteta you aia e ace a conpteet 3 a erioekel, fin be Sik weesatesposimai 1 00 de oleae de IgG iste nimple pet css aes la oda sent dened urd cele penta nga dou Gomer Ces tees ‘scl de ate, {Compleval Clos este menu inact cu tora uel molecule nami CI Inhibit. Tegafes Clg a fagmence Fe condo laliersca Cla ila oder cenermainae ale Clr care vor tansfom asst compu irt-° Sern poten activ Cli copa st sivens Cle iso atone astfel trea ean stl Cie ata vm ten clon ara mul et sbstat, mlocula C4 ogicprtiag format din afl o,f $1-). Pan hdlzares ual fragment me, Ca, de tel) ‘atl Sern lanl west expr mse de gare den nivel fermen mare estan, C40, Arta ee pat ats (Gate mane sims ev xe dsr pericarp (3b in veces os Cl cea ss pee trie procrms C2 0 alae Susu expus a fui Cab Cs va pea ets acu supe cell det os sur ra clva C2 arn fagatnt mle (CD) cre Ye ‘is si un fament mare, Ca ere, Inpasnd cv Ci, fonnes2éconverias Cha ci cis, Acta va pute clive compu! C3 eerie fra aia Fragen Caste g naling ia val yar a abcata complemen (Obingies melee de convened pote gomra pte 20) de moles Je Cib, cova ot ican 0 amplicae fae importants Une ase molecule Cb se leeg a C492 pen a fomna ut compen teolecuay C4¥C2ACb nuns CS converts. Comparetal C3 a st complex ela a C5 gi altereaa conforma, ste neat CAC pate cia CS in C30 gf CSa, C58 eto anasto v8 ‘haber Cb, corpus buses aed la Céline! orate complet de aa meant Cates eter Lines proce care se eae carboidi Cakes lester, ai cals thermal, a ners anicorp pe ave. Cu ae aenea, econ ee mal pcp decal clase, lind o mune de eaeponente ale ace eh, eceece, dup iii, acioneaed pin itemedal componente Cg C2 penn & probes 5 comerazs, Deas cale este actvata de care MBL ~ mansse badig lin, cae se lag rerlune de manoos ale glicoprtinlor sau farbohrator de pe supra uoormicooraniae, MUL ete considera o pid de ‘az acd produ th ea ispunsrioe Inna Fanci en cul ten complet exe since aa Ce cae seamina din pont de seers srl. Duo ce "MBL se leag a sopra cell saa « plogeaull, irvine opr Sct MASP (MBL asi serine praca) ae sc ea38 ea Se Toa tel complex sty care cndice I lars #etvzea Ci, MASP sre semsnst srt ev Clr gt Cis cea le ima stile. Detaile cite ative lonclor im n continu Tk neces Secyenjs terminal formarea omplevulal de ate membeanar (Cao consi a formal converae CS, aceasta cians compas C3 coe ste frmat cient 1 unt Dap egare C3 emg C39 nena a eonverazcaptul NH2-temina a lanl este lv. Aces clare generar un comps mic Ca ae ese elieat jut fagner mae C3 care se lag sual cl! forza un sar de lace pra 0 mpi 3 ‘empleo Compusil Sb se exe de bl ese inca i wit es a se eg compl CS Pi in aes pune, oe reac compels desir pe supa idoiice ale menbralr sa lanl complexelo inune {nach Guidi Cin C00 eas C7, compleul care reals sues 0 wansomaue social hidoflica~ aniics ce expune rele Isofbe,acosea sar ca sinc de lear prt fost membrane, Dac rasta apie pe membrana cle fet ile Iofbic de legate pet compli C596 18s ieee intl pie al mena Das een spre pe complex. nah ‘olubi sso peal supa sctvatereneo-) Activates tit casi pote fsa pin menierea computa C4 fn sta SOMA. Acest cu se poate fac fe pin Iemeal petelned stile Ca BP (C4 Dining pete ~ prea de lear a C8), pon isermedl nor patelne membrane CCRI MCP (nenbrane cofactor pti. Aces ultinedous maleate sto ain pen ator aber. Logeea ota ine ace enimera massa C4 prevne asaietea aces compas ta coups! C2. Ta ps corse aac eg, lene face care va iva CH leat Tn C4a i Ce sl,@ eit membrane i = Ea ont H 23 E CAbBP or z SO RL or MCP & 2 Factor T ‘Bound Cab Che ©) soir litre CA C2 pote prevent pi nema! DAP Decay Accelention Facto, DAF exe pcopotn ancy ‘ovale a plcofestlpid membrar Tapes converars C3 cil asic es format poate sola pein inexpedl DAR, CRI C+ BP 2. Reglarea call alternative 5) Fao (ouch aaioneae a mip mel ‘soso sou CB ese aaceren efter Bc le valopa formar coavenaeis Pt rea a sara comps 8 dt complete C¥BD sa C3EBD inca cau cofactor petra fairl 1 © eg ent pan oe 1) Factor 1 mcs interveta une cofacoré CRI i MCP. Bec asfimi ar este de iva a compu C3 ia rage [ropesiv tal ic i iactve din punt de vere al cect de acvare a cave complement dat uns inte aes Iragmente i pnt capactaten de egscotae. Awe Ca va ansfomat nit (C3, ba agent CM 0 eer pl ICSb vai clvar in Cae Cade (car pkaeazd leu Hosoi cpactatea de gael spre) ) Ue prseine relator ver action ase creel dj orate, dsocindo, Ca cua ea case inerin CR 31 DAR,8. Reglarea eit post-c3 8) Cepacisen C3457 oe se loa la supra cele gate amos chiar celal indonne, Copacistn de waslonmare da sama hdr cea ldots ete ren pens acjaea acest complex. ASL, rein S (vive) se poe algal compet Hier, mend sae ireil preven aera lt membrane clu fps, cst unele cel ae au ceo penta ‘vnonctin i sunt sponse pen clearance actor complexe. © Bound Vf — cho? S protein Cannot attack nearby cells 1») HR (hamologas striction ‘ators CDS9 (IRL — membrane inhibi feactv ysis) prtjeaz elulelecrgansmul de cl especial steal complement pein gue a C8 prove asanblii C9 (i sera hembra) Aes ea do iterveatie ‘Spon i en Cy HR pee cpu ear i pe eet et cnn ne cannot polymerize ©) Commplow MAC, of format, pat enokat de tre suse mle, Clee ete rivet) sme ml i seas a sejne siemul complemen. Receptor! pene complement Tiguan ‘Disb ear CRTC) CO ecezfomnarea C3 convertase complexe imine ‘wiveeie,—neurtile, ee, Imncofge, cociofe, cele flare develo 8 anee Ieee 1 CREAT ‘Cig, Ci, Naga EHV Tinfoete B. unse Tinocite T. unele fate ap respon ol B, Gale eile, cet fliers ewes CRE CDINCDTB) | 1S naa, eT Tmonocis. —macotage, nacelle, NC Sina infocte Tose fll senetioe mao ‘nonocie macaee nes THERE Che "aso an ATE induce degranlarea maser bz THRE CS Taaoate, bas palo, eT, indice degramlarea maser yi bzneor nace ombocte celle eectsConscis belgie ale activi sistem complement |. ‘Lea uor clue, batori sau visu. Ul vin EBY, absla ct) pet tira tone ele 3 i ale completa, Newraliarea viral ee pasa pin rear de area, rin crearea una sat pete anor $i mokeale ale complemen) care ee anaes ils de nets ello spel vnsror epsonzate deere CRI. Dact eae inplate st Sagoo fire vile sunt fagocte 4 dlinse lancer Aetarea complement coodice la fagmentaren anvelope vile fl Aszntegracanscleocepi 2 Opsanizarea, cae prooveart aol fgoctoraanigcrelor panicle. Prinipaie opseine sunt C3b, CAs iC. Tapetarea une ‘poe eo Spain cooduce a snares acl cule cre a ecto ert complement por. Dac cella esr ie ut fagoc auc! pros de fagocious i neacellar yr f mpicae Acivarestagocelor de ce agen, lacs C3, nlc lacrerea umd de meleule CRI de 5 00 peu fagoc I pas, 5000 pou fagoct ative. 3. Legare de receptor al complemeall dep soa eee sstembll in cea ceva decane acvarea ior rspans cum si roca iflsmatr sees Go moloueinurowglatnt care solic a area espn wn spect ~ degriulteamasocelr si bazailor’ © deqranlareeonneicioe| © eaimvaraeascteroann vector a vel sts last © agregatee pucnewior © mhbiva igri macrtgelers inducer eri de pron irre de retain maa nol ‘libra de enaine droits de cite eu © eres expres de receptor pen compen CR siCRS pene | Gesmnce men indpirarnsomplereloe me dn ciate pert sms pins sav Scala ue vor data, Roll cl mat prance naan ce ua deer, cae pel po suet capa’ CR Unreal aparn prada eto el proc pe car sister cemplemee jac in reproduce. Stemol canplemer ese preert comple fare eal epreoetr feria game peri cari recut de pair rego Spermatooit Snt de ‘strane prot de acne items complement pin MCP. DAP qi CSD. C3 ete seta nar ct spn la earogee, St Seta ee boca de pgeserun. MCF. DAF CDS9 sur expat a nell ofeblasu precace teva sail. MCP [DAF av prezent arabia ave suo fel, iti ce CDS9 eae prezet ariel tr Fs, dang neg period sre. Tesi dela hr mater etal. med parr, «aie ces de petine veglto se Ssepullceplement AS? a @ « 4 4 & \/ wheat ws i : ie oes A AAAPAT Db tel oreg ie 4. Infamatia meats de complet : ‘Suse! compenent peso un meanien extrem de putrle penta inj si ampli inte. Leginra dire. steal omplenet 5 iaanafis es aig apm od de clve hageatle mil nant anflatnise case east pn elven C8, C8 (C3 (Cia, C4, CS} Anaixonnele Benfiaza de receptor dsciuip= spat waar Yai eelule, dar un Yl cbse exe jvc [Reivaen mastoselr (a econ stn eu, azafia) conmice a cepa acer a ere Stor pre fomat, ezet ia raul. Apo, pen tabla dau arhidoni, e pe ea lpoenigenanelr i pe cale cik-sigenarion Se shade sera eeucorine Ba Ca De (SRSA), espe shieza de posal! rmboxan Tata pam He Haar ‘asa Gee Pee GT vasa ChE Bionocoatehe B-gcoraninidae Scndeartscraiea | EF Faso cRemaare pet eae 1 NCP Taio cheat pr tof | Par (actor SSS PRCT Elbe dente This Aatvare Mi deca Podoo eposne Tad waa, we] GMicse TNF | Teasineiay Tit Cae Tipo | Tacx i a a Cate ia -igomaTor Provaalanie ‘Aare PCA, TE OTC TroabocanEfecel fico elite de clr wnatack rele fa fptfenomoncle care as lab procul infarct ea ied (ize capiaesy ede (exusnes Iso pacino plastic, fa sae se sgh cemtactsm cell, spell neuf, “isctaclulor in vs sanguin ste reazezs prin proce! dodger, medic jal unset de maceule de dene 6s ee. Intouminceral de eteva or, neuofiele vor anireste tn proce edapeezt pin endl ea nivel sks inflate. Prooes ue part n#exape sce a eae Se papa ub AS 1 recog: inenja nor der acter eiberaa nivel tsar (hissing kin — IL-1, TNFa) pe supasta celuleke i apr sale Rl P-Acsies we vor laps no manera reveled icine sao iil Lene ‘pe supmiajarewroiclr. Acasta ve Iowa doplsuea neal. Selva so vsopaeased pe supa endl {Gut ineraconea ao: peed deooecule de ae) da a opt 2. sativus pe mis ce neil ee moguls et activa de dives chemoarrcant le ex PAF pce acivating factor, (Cx, C5, CST; chemokine IL, MPI = macroohage flammatory fret). Legare heme a rseior ce Pe ‘upaasnetrofivs conde Io modfcre conformal a ineeicior ase lu erejerea ani lor pny maleclce ‘dc adelune paring sapere! iol 3. kare: legoeaiegieor de mare afntze(LFA-I) la molecule apron supra inunolobulinalor (CAM-4) va face ca aernea poles la edt se ea ste 4. tavern pert erdtli eda de chemotactic reese grin lee in superaii cor al sul de mae (att ce neue sang in fs ago i elibererd maior are wor comb rn fora menace proces ‘aaa. As, MID-1e gi MIP asin ear macrfegte care sung Ines, 6 or, stave vor seca diver eto a tinal or Pe ings masoce, macrtaele repre elemente mare desta nari. Macrofagste activate secret HL, 1L6 gi TNF respomabile at pea efeesfcale(cogule creeea emeabilai vascular Sinuaes expres de aceie Wo anne sara proce de chenokire) ct) prt cee semi dn tng Process Ingmar ibe scesar fan ya conde ln ut flex emset de cle fost neti, monet, covnale, bro, mastocie, eare contbul! a linea agen prema ndash ‘ura inlensaes proces infamstor aut stu elt, i ial dnd per contro dite slr gi dln ed, Peni 2d potas erent merase de repre. 5-4 demonstrat ch TGF joacd um asl de tl sn ita lanai ‘eumlaea praiferars fobs depunres de arc exacsur, (Sa, cea mai ptemich safioxit, owe action ca Insts ca un factor chemotactic pent netofle. poe stonn dice ses ‘endo cil (rodcind wsaalune #ewerespermeiaa vsculve ~ fe riot de it levees), Reaciorea ‘sernenen ot monocile f haptotl, dtralndd elberrca de caine al modi. Atl, I-66) CS nue repo de fd jeu {Carbosipepidcnsrick N (SCP, su factor chemctactic inactivate. CF) eveanh apd tna Crema din Cia, Ce gt CS ‘omeledes-Ai ale ariexicoy st epabie sem lege econ or ‘Cascada complement imeraonez de asemenes 9 cate cascode decane einai: comguse, generic knnlr$ irinin ‘0 ait coneuune tae comple ace sate ete agua de pin eerie Cl inibier. Acs att naman Ce gi Cla ‘a Fas XU ru de cage allen sen lor plana casa! inte, Fgura de ms us Pez irerenia factor Cl In sg bara), "Proce deer yer esto ese svar cz aor celle, extn fern pant de vedere a molecular de serine > tNFeestinulesh expose sles EL stimulszaexesia de ICANCI i VCAMC, iL: 91 TNFeu tinued macrragek celle endo inducnd secre de cemakine, “Fo CSanrap sn os 2m atte chemetactickActivation of Factor 1 ee ciation of civabon ot vali proscar earage ieninogen to genera bradyi vasoactive pete Cleavage of 2a oaow to genes C2 nin, sanretts ‘vasoactive peptide a Generate plasm Cleavage of C2 Seems LIE anus] ‘rota de railaoxin pare mimic. consvinaesett site complemen, dar ce uae a stil alter stem cat ptctina a mod diet C3, Ca wiCS Aut! Bo name ced pas aiken, ezine soem aveokare, st pcsne bac Mocanisme microlens de esse stall sstemaa complement Component arabian Nesom ace Cram megane ana Mag TT Tau aang ovina WAC Prine a nivel supe cee ‘WAC intercon ote menaare ious WaT ‘nombrra besten Ta siafionnee Cia 91 Se Sat Hasina oe Ge Gale bctesene Teed Crampoatine Ta pep Teg MAC i Tapia Soom wa pode pepo ‘apn cena capsuls Knish o bane ied tae C3 depen pS membrane bacterin 3 CR dee agi “Aerob POC Ge TINGE EE PRA We sineuut | PORE pe Hara THOR, vn, PR, Fgh ‘complet Pretozsuf care otha cascada sstemul complemen EBV, espe inp, Typannsone cu Candie abc) Clute matigne sant de stern fern locas ster complonet. le sunt a erie ele se alee la apace de a ‘edosea epa ompx MAC. Deficlnfle Sstemalal Complement Defcenjlenonosigt ake conpanttor ini ec chic (Ca, Clr Cis C4) ceo nace snptome:persienta Cin srs! apuris de boll ca LED pus eiemaosebemind, loneruloneit,wsclie,da ila imnodeicerte mane pin init ‘ecuree cu Bac pegene ate cre od pu). Detiejle nasser aco conde a itrodetiiono inf rcuente ca Neer Deflerele C3 sn cole ma severe. Apr infec eure ar essen Uns. Deceit componente MAC crdu a neti reuters ca Neuer (mong igor. Defies In CLIa conde a anpceen ered, carseat rn ese ela Dericeseecospotentee eslatears DAE gi HRE apr stor wfc anc lor a mewbrard Apa o aera orotic ernst st Insnopobingeieral est regis rn esmololM