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AppliedBiopharmaceutics&Pharmacokinetics,5thEdition
LeonShargel,SusannaWuPong,AndrewB.C.Yu

PrefaceCopyrightAuthors

CONTENTS
Glossary
Chapter1.

IntroductiontoBiopharmaceuticsandPharmacokinetics

Chapter2.

MathematicalFundamentalsinPharmacokinetics

Chapter3.

OneCompartmentOpenModel:IntravenousBolusAdministration

Chapter4.

MulticompartmentModels:IntravenousBolusAdministration

Chapter5.

IntravenousInfusion

Chapter6.

DrugEliminationandClearance

Chapter7.

PharmacokineticsofOralAbsorption

Chapter8.

MultipleDosageRegimens

Chapter9.

NonlinearPharmacokinetics

Chapter10. PhysiologicDrugDistributionandProteinBinding
Chapter11. HepaticEliminationofDrugs
Chapter12. Pharmacogenetics
Chapter13. PhysiologicFactorsRelatedtoDrugAbsorption
Chapter14. BiopharmaceuticConsiderationsinDrugProductDesign
Chapter15. BioavailabilityandBioequivalence
Chapter16. ImpactofDrugProductQualityandBiopharmaceuticsonClinicalEfficacy
Chapter17. ModifiedReleaseDrugProducts
Chapter18. TargetedDrugDeliverySystemsandBiotechnologicalProducts
Chapter19. RelationshipbetweenPharmacokineticsandPharmacodynamics
Chapter20. ApplicationofPharmacokineticstoClinicalSituations
Chapter21. DoseAdjustmentinRenalandHepaticDisease
Chapter22. PhysiologicPharmacokineticModels,MeanResidenceTime,andStatisticalMomentTheory
AppendixA. Statistics
AppendixB. ApplicationsofComputersinPharmacokinetics
AppendixC. SolutionstoFrequentlyAskedQuestions(FAQ)andLearningQuestions
AppendixD. GuidingPrinciplesforHumanandAnimalResearch
AppendixE. PharmacokineticandPharmacodynamicParametersforSelectedDrugs
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