BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 wlles CHAT TAY MAU LNOI DUNG. -Dinh nghia v8 chit tly mau trong thye phim, -Mot chit tiy mau sir dung trong thye phim ™) Tinh hh sir dyng eit tdy miu ign nay Lo ich vi chica cht ty ma, z inh: BUN. ICHAT TAY MAU TRONG CONG NGHE CHE BIEN THYC PHAM. IL1/ Dinh nghia: Chit tdy miu ding trong ehé bién thye phim 1a. m@r chit hoa hoc c6 Kh ning Kim mt mi cria mot chit khdc. No phd vo ede lgn Kéx mau vito ra nmg ign két khong ma. Nhin bén ngoii, ng tgu ding thy miu sic ea mén dn rt tring. Thé nhumg. cing vin tn tai nguyen ven cd hai ha chit, bao gm mau sie nguyen thuy eia mén an vi chit héa hoe phi mau, Ding nhimg thre phim nay, nw tga ding en nhign an kaon ha chat tay trang kia II/MOT SO CHAT TAY MAU SU DUNG TRONG THUC PHAM. ‘Tren thye iy tring van durge phép sir dung trong thye phim, nhung chi gidi han & rot s6 chit va him long cho phép. Tuy nbign, vi loi nhugn, nguéi ban thing sir dung him Jugng vuot qua mire quy dinh Sau diy la mgx sé chit viy ting ding trong thye phir. -Nuse ony gi. H202 -sunfudioxide: $02 Chat tay miu trong thye phim Trang:BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 -tinopal -pychotrin Nhing chit khiée: Magnesium sulfate: MgS04. Nude oxy gid (H.O;) it Iong trong suét, nhét hon mot chit so voi nude, &6 cae thude tinh Oxi hoa manh va vi thé li chat thy ting menh duege sit dung nu la chat tay fing nhur Lam chit Oxi héa, vi (dae bigt 6 ndng dO cao ohur HTP) kim tic nhan diy trong tenia, O-xy gia (Hydrogen perxide) 06 tinh é-xy hoa manh, thutmg ding dé rita vét thong, digt vi sinh cong thye phim, 6-xy gid ¢6 ta dung sit Khun vi tdy tring. Logi ny chi dng dé hi trg ché bigm chir khang pha ph ga thue phar ‘Té chi Nong huong Thé gidi cho php sr dung 6-xy gi trong dumg, nude qui ép va muse rau voi diéu kign khong tro thanh mdt thanh phan cia thye pham. Tite la, ban 6 thé str dung Sexy gid nt thy pm, sau dd rua a bing nade sch iu trite phan tr cua nue oxy git 11L.1.2/ Téng quan Danh phip IUPAC Hidrd peroxit hid didxit aoe hidraperoxit Céng thite phan te HO: Phan wt gam 34,01 g/mol Chat tay miu trong thye phim Trang:2BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 Bidu hign (Chit long trong suét S6.CAS 17722-84-1] M1L.1.3/ Thuge tinh Ty trong vi pha 1,4 gem’, long 1} hoa tan trong nage C6 thé tn Kin Biém néng chy -11.°C (262K) Diém s6i 141°C (414 K) pK 1165 pK, BO hot 1.245 eP 620°C TILA Ney big MsDs. MSDS ngoai Cae nguy hiém chin Chit xi hoa (0) an mon (C) NEPA 704 Ox) Diém bat lira Khong chiy R:5, 8, 20/22, 35 eee S: 172,11, 26, 28, 36/37/39, 45 ‘86 RTECS MX0900000 IIL.1.5/ Cac hgp chat lién quan : natri perdxit Cie hop chat trong ty métyl perdxit idea tribxit Chat tay miu trong thye phim Trang:3BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 Nuée Cae bop chat liga quan Oxy, Ozén Hidrazin I1L.1.6/Si dung. 111.1.6.1/Trong gia dink hi & mg d6 rit thip (dub 5%) nd duge si dung phd bién dé ti tée ng. Voi nding d6 cao hom né 06 thé Kim chay da khi tiép xiic. O néng 46 thap (3%), nd duge sir dung trong y hhge dé rita vét thurong vat loai bo cde mé chét, Cuc quan ly thyre phim vi durge phim (M3) da cho php sir dung mus Sxy git 3% ("Cap thie phim", hay khong o8 sb sung cdc hoa chit dn dink) nh i nude nta migng. Ce dung deh perdxit throng mi (ch yeu la HsO> mua te cic higu thude) liking thich hyp eho vige wing né do ching chia cic hoa chit bd sung 66 tinh dé hai. Perdxit thuong mai, nhur cic dung dich 3% mua tai higu thude, 06 thé sir dung dé tay ede vet smu khoi quin ova thai, 111.1.6.2/6ing dung cong nghigp Khoang 50% sin Iuong hidré peroxit ca thé gidi nim 1994 duge sit dung dé tay tring gidy vi bot gidy. Cac img dung tay tring khdc ngiy cing tré nén quan trong hon do hidrd perdxit ‘duoc coi li chat thay thé 18t hom ve mgt mi trudng so vii cde chit tay gée clo. Cie img dung chi yéu khic trong cdng nghigp cia né cin bao gim ca vige sin xuat natri pereacbonat vi nati perborat, dye sr dung nh Ice chit ty ria nhe trong ec Toa bo gift 44 git I (ai), No cn durge si dung trong sin xuit ede hop chat perOxit hau eo no d6 nhir dibenzoyl peroxit, due st dung nh a eit moi g6e te do trong ede phn ting tring hop vi cic phin ing hoa hoc khic. Nb cing duge sir dng dé sin xuit cit Spot ching han ah Dropylen Oxi, Phin img vi cdc axiteacboxylic to ra cc "a xit per" tng ting: vid axit Deraxdtic sit dung céng nghigp duge digw ché theo cich niy tr axt axéti. Twomg tr ait méta-clordperoxybenzoic (MCPBA), duge sir dung nhiéu trong cée phong thi nghiém, cing duoc diéu ché tir axit meta-clordbenzoic 111.1.6.3/Su dung trong y té. Nuc Oxy gi duge sir dung nhur la chit khir tring va chit khir khuan trong nhiéu nim, Trong. Ki vige sir dung né da bi suy giim trong nhing nim gin day do sy phé bién cia phim OTC o6 mii vi d& chiu hon vi e6 sin hon thin vin durge nhieu bénh vign, bie si va nha si sir dung trong vige v6 tring, chan ring. Chat tay miu trong thye phim Trang:BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 Hidré perdxit 35% cip thyc phim duge goi ki "made oxy gid" dle coin a liga php hid perdxit. Nhtng ngudi ch tuong st dung sin phim nay cho rang né 6 the hia losing va sr dung trong “Liu pip sigu xi ha d& di ti AIDS, ung thu va nhigu bgoh Khe; mot sé eng kéu ea ring thong tin vé cae sit dung e6 loi eda perOxit bj cim bai cOng dng khoa hoc véi ce gid tri y hoc hay ti ligu TIL.1.7/Cée thuge tinh vat ly Solid (erystal) Hides perdxit 6 hinh dang “wién Igch”, do hee dy gita cée etp dan tn ce nguyén tr dy. Mac dit trén the lin ket O-O la mot ign két don, phn tt o6 rao cin eao ding ké dé the hign vong quay hoan hao la 29,45 kJ/mol; nd cé nguyén nhin la do lye day cla cp don. Cac aac ign két bj anh hung chi yu bai in kt hidrd,n6 gia thich sr khac bit gita cic dang hoi va tinh thé; thy vty ngubi ta da quan st die mde khong rng gi triton ci inh the chia phn tit HO TIL.1.8/ Cée thuge tinh héa hye Hird peroxite6 thé phan hiy ty nbign thin muse va 6xy. Thong thug n6 phan ing nhur La rit chat dx héa, nirng o6 niu phin img trong 86 n6 phi ing nhs fi chit kh, gisi phong a Oxy nh Ii phy phim. N6 eding rit nhanh chong tgo ra cae perOxit vO e4 Va hit ec. THL.1.8.1/ Phan hay Hidrd perdxit thong thudng phn hily theo phan ing toa abigt thinh nude va khi Gxy m6t eéeh, tur nhién: 2 HyOp —+ 2 H:0 + 0, + Nhiét Ingng, Phan ng ny la than: nd cb AHP -98,2 kol vt AGP -119.2 kiémol. TY Ig phn hy pha thude vo nhigt dd, ndng d6 cia perdxt, cong nha li pH va su c6 mat cit ce chat Om din hay tp obit. Hidrd perbxit ky wh nbigu chit gay ra sexe tae qua trinh phn hy n, bao gm phiin lém cac kim loai chuyén tiép va hop chat cua chiing. Céc chat xe tie pho bién nhit la mangan didxt, kai pemanganat va bge. Phin ing y nh vy eng due nie tie bing enzym catalase, tim thay wong gan, ma chi ning chinh eta n6 trong ea thé fa tha loa ede sin phim phy dc hai trong qu tinh rao di chit vi khie oxidative siress, Sy phn hy dién ra nhanh hon trong chat kiem, vi thé axit thutng duye them vao nhu la chat on dinh, Chat tay miu trong thye phim Trang:SBKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 TLL.8.2 Phin ding 6x4 ha-khir Trong dung dich nui, hidrO perOxit thé Oxi héa hay kh niu log ion v6 ea. Khi m8 nhur mot chit khithi Kh 6xy doe tao re. Trong dung dich axit ion sit Fe" bi xi hd tinh ion sit Fe", 2 Fe (Dung dich) + H:02 + 2 H'(dung dich) —+ 2 Fe"(dung dieh) + H:O(l6ng) vva sulfit (SQ; ) bi 6xi héa thinh sulfat (SO.? ). Tuy nhién kali pemanganat bj khir thanh rmangan Mn” bith axit eta HO, Thi vj 18 dui ee digu kign mt trutmgla kidm thi mot s6 trong cic phan iimg nay la nguge leis Mn’ bi Oxi ha think Ma‘” (trong dang MnO,), va Fe™ bi khir thinh Fe" 2 Fe + HO: +2 OW +2 Fe +2 1:0 + 02 Hidra perdxit thuong xuyén duge sit dung lim chat khir trong héa hitu co. Mét ling dung Ia dé Oxi héa cdc thioéte thanh cic sulfoxit. Vi dy métyl phényl sulfit bj Oxi hoa thanh métyl phényl sulfOxi TILL8.3 Tyo thinh cde hgp chit perdxit Hides perdxit la mot axit you (pH =4.5), vin o6 thé tg0 race mdi hidroperdxit hay peroxit hay cde din xuit cia nhigu kim log. Vid, vi dung dich axit cromie (C103) n6 66 thé tao ra perdxit mau xanh lam khéng dn dinh CrO(O.)2. NO cling ¢6 thé tao ra cdc Pperoxoanion theo phin img véi cdc anion; vi dy phan img véi borac tao ra natri perborat, li. rt chit ty sir ding trong ec bat git: Na:B,Os + 4 HO; +2 NaOH —> 2 Nas (OH) + chuyén hd cde axit eacboxylic (RCOOH) thinh cic axit peroxy (RCOOOH), mi te ching Ini dpe sir dung nh lacie chit Oxi héa. Hird perdxit phn tng vi axéton dé tora axét6n perdxit vt né twong tie voi 6zin G8 to ra hidrd widnt. Phin ting voi uré to ra cacbamua perdxit, duge sir dung dé lim tring ring. Cén bing axit-bazo’ véi triphenylphosphin Git i *ngurvin chuyeén* hi ich cia HsO trong mgt s phan img. A/ Tinh bazo Hidr6 perdxit ld mot bazo yéu hon ca nude, nhung_né ¢6 thé tao ra mot s6 san phim vii ede axit rit manh, Siéu axit HF/SBFs tao ra cde hyp chit khong On dinh chira ion (H:0;). TIL1.9/ San xwat Naiy nay hidrd perdxit duge sin xuét gin nh duy nhat chi bing sr yt Oxi hoa ea 2-ctyl 9,10-dihidréxyanthracen thinh 2-ctylanthraquinon vi hide perOxit sir dung Oxy te Khing hi ‘ut anthraquinon sau dé duge chit ra kh6i hin hgp va duge khis nara tra th hgp chit dihidrOxy bang kh hided v6i chit xe téc kim Tosi, Phucmgrinh tong quan eta qui trinh niy duge dan gidn héa nbu sau (d8 shim Lin +O. Chat tay miu trong thye phim Trang:6BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 TIL2/Sunfudioxide : $02 Sulfur dioxide li mot hop chit hia hye v6i cong thie SO». Chi khi quan ung ny 1 sin phim chinh cia sy détchiy hop chat hau huh va né li mot mai lo moi tong ding ke. SO> thugmg diem ta i mai ho ca huh bj dot chy" nhung no Khng ph la mai rng thdi, Dioxit Lum huynh ka m6t khi v6 co khong mau, N6 ob kha nding kim mat mau dung dich Broom vi kim mat mau trong the phim 143.1 pm Zz SS oO e2 Sulfa doxide ‘Tenkie sulfur(IV) oxide; sulfurous anhydride Nhan dang S6 CAS [7446-09-5] S6 RTECS WS4550000 Thude tinh Céng thite phan tir SO: Phan tir gam 64.054 g mol! B& ngoai colourless gas TY trong 2.551 g/L. gas Diém néng chay ~72.4 °C (200.75 K) Diém soi ~10°C (263 K) ‘Bg hoa tan trong nude 9.4 y/100 mL (25 °C) BS axit (pK,) 1.81 Cu tedc Hinh dang phn tir Bent 120°"! Momen lung eye 1.63 D Céc nguy hiém Phan logi cia EU Toxic NFPA 704 Chi din R Ban miw:R23 Bin miuR34 Chi din § Bin miu:$1/2 Bin miu:s9 Bin miu:S26 Bain miu:S36/37/39 Bin mu:S45 Diém bt lia non-flammable Cie hop chit lién quan Fiop cht Fién quan Sulfur trioxide; suture acid Chat tay miu trong thye phim Trang:7BKTPHCM-KTHH-CN THUC PHAM-HCOSTP1 Msps MSDS ngoai (Cae nguy hiém chin SPO a: o) NEPA 704 Si ‘igm bit tira Khong chiy Roiro/Antoin RS: 820/22, 35 S: 1/2, 17, 26, 28, 36/37/39, 45 S6 RTECS ™MX0900000 Ca trie & thude tinh my, viv. Dir ligu nit dng he Fs et Dir ligu quang phd UV, IR, NMR, MS natr perd Céchgp ct tong ur méiylperdxt hiro trix Nuc Cac hop chit lin quan Oxy, Ozn Hidrazin Chit tay mau trong the phim Trang:8BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 + SO, la mét oxit axit + ©6 tinh oxi hod, tinh khit + tinh tay mau Sulfur dioxide la chit kh e6 tinh 6-xy ha manh, rit de, e6 thé gay te Vong. Sulfur dioxide duge ding dé tay tring trong cdng nghigp vai syi, x6ng trai edy dé bao quan. Chit niy e6 thé ding dé bio quin vi ché bin thye phim, nhung him lugng cho mi yi the phim lai khic nhau, Ching han: Gigi han t6i da eho phép cia cée log mit kt SOOmp/kg, ce mon ain goi li SOmg/kg. TIL3/Tynopal: Hinh 2: Tynopal inopal li hoa chit ty tning thiog duge sir dung trong cdng nghiép sin xuitgidy, vi, so im si dung cho ng in. Tinopal drgc bin dus nhiéu t8nthuomg mai nhu Tinopal-AMS, Tinopal-DMS, vv... va hing chit nay lim tring béng va phit hujmh quang trong bot vA chat long ty rita (detergents). Khi dun néng, Tinopal phan hay va bée hoi nitrous oxide (NO) va hydrogen chloride (HCI, Tai Hoa-ky, Tinopal duge ding ky véi co quan bio ve sinh thi nhu mot chit 5 nghé theo dgo Tut kiém soat chit doe (TCSA: Toxic Control Substances Act) Tai Au chau, Tinopal ding ky v6i Hi ddng Au chau nhur héa chit tay thing kY nab. Chat tay miu trong thye phim Trang:9BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 O tinh trang cap tinh, Tinopal gin nhur khéng doe khi in vao, khOng lam rt mat hay da vit khOng phai la chat lim nhay cam da. Trong nghién ein ubng lau ngay (kéo dai 2 nim) véi chudt lon vi ch, khong thay r6 dau higu doe tinh toan tn ngzy ca vei mite cao 1000 ppm (0.1% trong thir an thuimg ngiy. Tinopal khong gay dot bign vi trig va dOng vat c6 vi khi Him thi nghigm. Trong y vin got y Tinopal Ia cht gay ung thu. hin 3: Ha chit dc hai dye cho vio & gi dogn tr ‘Trén thye té, Tinopal khong duye xép vio chit gay ung the biri IARC, chuong trinh de chit qude gia Hoa-kj, EPA (cor quan quan tr sinh thai Hoa-k¥) hay OSHA, ‘Tren mat duge dong hoc, Tinopal tigp wie v6i Tinopal qua da do do quan giat vi bat xi-phing chia Tinopal Mie div Tinopal tong d6i khdng de, phan iimg nghich do aust Tinopal Khi an bin khong thé ign don cha chin duge do e6 thé co nhimg chit ban lin fn trong Tinopal. Tai Au chiu va Hoa-ky, mudn héa chat ‘ong nn la chit diing trong thuc phim, tit ea nguyén lgu diing dé ché bién hia 6 chit lnyng diing trong thye phim (food grade quality) va phai sin xudt diing GMP (The hh tt san xuit). Vi diing kim thude sain xuat Tinopal khéng duge kiém sodt nghiém ngat nhur vy va nguyén ligu thude nhom chit Jingng k¥ nghé chir khong pha thye phim TIL4/Pychotrin: Pychotin li chit ty tring quang hoe, ding trong edng nghigp. Tuy nign, nd ti thin chit tdy ting wa thich eta cde ea si sin xudt bin, binh ting, bah canh, bénh bi, mien, phi Chit pyehotrin king thude danh mye eée chit phy gia thye phim cing nhu i try ché bi duoc phép sir dung. Chat tay miu trong thye phim Trang:10BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 TILS/MBt sé chit khae: Magn 1m sulfate: MgS04 Magnesium sulfate ding trong cOng nghigp dé ting long magnesium, gidp edy xanh quang, hop tot hon. Chat nay cing duve str dung lim thuoe nhuan trusmg, chong d6ng kinh, rit mu ‘mun not... Tuy nhién, né Khong duge phép sir dung trong thye pham.nhung cic co so sin xuat vin cho vao thye phim d& ting tinh cam quan cho thye phim. IV/TINH HiNH SU DUNG CHAT TAY MAU HIEN NAY Nhu ching ta da bit sir dung chit tay mau hop ly sé lim tang tinh cim quan cia sin phim Jam sin pham trong dep mat ngon hon, nhung hign nay cdc co so sin xuat da sir dung trang Jan,bit chip sy de hai cia né chit iy mau d3 duoe cho vio nhigu sin phim aku: bin hat ‘vin chau trong ta sta,kim wring min bi wong bok tung thu v/ TAC HAL CUA CHAT TAY MAU TRONG THY PHAM: gu qua khon Iwdng Tuy o6 ning quy dinh «ring ve vie sir dung ee eh hos oe dé ty tring the phim, shhung ng ban hing vin st dung qué tay ma khong cd bit dn hau qua. Hydrogen peroxide duge chi dinh ding trong yté dé kim sych vétthuong va st khan, néu tée dng true tiép dén co thé sé giy viém lost da day, loét gid mac. Ding thuong xuyén, Hydrogen peroxide stich t trong oc thé, c6 thé gy mguy eo" ung thi Chit tdy ting trong hye pli, néa ding qué gw hayng cho phép hofe ding lai ei si dung, sé gay tae dng den he thong dime teu hoa, nm mac rub, lam nim mac dmg tie hoa bi to, gay ri loan tigu hd, hap thu va bai Thin trong la hon Khi mua thye phim cé mau tring, ban nén chy. Néu thye phim c6 mau tring bat thuémg, ban dimg nén mua, Voi nhamng loai thue phim khong c6 nguén gée 1 ring, khOng nhin higu, bao bi, khong dia chi, tén tuoi cia nha sn xuit, co s6 che bién, khOng han sir dung, mau sie bat thug... thi ngui tiéu ding khéng nén mua. Sau khi mua thue phim ti chg vé, nén rita thit sach dudi vi made, ngm nude vi ria nhieu lin dé gidm him luong chit tay. Han ché mua thye phim ché biém sin. Hay tr tay nfu nusing dé dim bio an toin Chat tay miu trong thye phim Trang:BKTPHCM-KTHH-CN THUC PHAM-HCO8TP1 Chat tay miu trong thye phim Trangel2