element natural biological origin or derivative of it by various methods, or artificially produced substance that produces effects on the central nervous system by changing the mood or producing pleasure, and may have abuse potential. This term is also used, especially in the field of medicine and pharmacology, as a synonym of active ingredient or drug, either by extending the concept or because the literal translation of the English term drug, which makes no distinction between the three terms. The original WHO definition reflects this generic use, however, the more specific definition indicates that drug is the most appropriate term to refer to substances used without medical purposes; alter affective, cognitive and behavioral aspects; can be self-administered; and may induce adaptive biological states in its users.