Prenatal Hormone Exposure
and Sexual Variation
Hormone exposure in the womb is instrumental in shaping
the sexual anatomy, physiology and behavior of mammals
John G. Vandenbergh
Peat ses date
Erie ph tly
for mamtals elias ws one X
fn one Y chromosome develop io
ales Thos withewo Xs develop io
Feral: Detngushing between he
buling mals and fale should be
Saightforwaed. Unfortanately for
those wh ke simple ls thes)
[armorecompiex
“and ¥ chromosomes are ony the
bepining of sex determination Bis
tlste have recently taken a closet
itok a the events betven feta
tion and sorta matty tht estab.
lish a naval sexual character
Stes. These events help explain
‘aiabily among individuals in sexe
“a anatomy, physiology and beh
for For example, an XX individual
fn exhibit some masculine traits if
formone prodiction or sensitivity
Sora duringearly developmen.
In fact hee alt cortinas
of sexual rts betwen mae and fe
tae The abilty of envicrmentl i
Fences during development pro
de such a contin demonststes
‘cc are and min ak 9
Synergy Goes ae enone work
tgs to proce an organism. Spe
llc genes ae only turned on when he
“vionment ofthe cell tisue, organ
‘rongantan cal for hem he cae
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ace oe taare
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ee
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of snl cant one chi
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exc of orm
imate te tars at
by elo ite losses whe
Sy evel Broghoa the yen
tne ten fey
‘Some las hamactes
sec nays tt produce hss
ea encod by te pom
Dat homo cnantziast nb
SOINCHY ny fenton
‘ental actos ceding Sd
Soong, npr rd ino
fear intr forbes eneetnne
Ths tc epi a gee ina
Tey otic cll oad tees
Ses peng nace phy
Eee aatt cee
ey gums ens ae
eth tow how fevmones
detopment in he womb, pc:
sty dene ha inter antes
‘PEaetver iy adlt morphlogy
apie an sored bea
Rs orders he en
Shy ota i
ply an mptan eh va
Stmone’nininy nto
Substances on alba and human
Renin arlene
Hormones and Sexsal Devslopment
Ofcourse set hormone curt Pore
Fa lic atthe time of pert Any
‘ne whohae wate a puppy develop
{Mo anadul dog haste the decine
insipperchewingchavor and the =
‘resin interest In the opposite se.
mak androgens such a testosterone
45 puberty to seule the body n>
itadtshope and prodoce male phys
tology an behavine In fees,
eves ofthe gonadal hoemanes est
_povand progesterone at puberty elt
incharacterisilly female adult body
shape, physiol and beaviog
Tet she only persd af female
development ats Caracterid by 2
Isyeinge in gonadal hormone att
ty'inconeart males experience v0
Sirgen estonterome concentration
{Te int bogie during fetal develop
ret the sora moze eta
fetes begin fo produce testosterone
riray trop gestation. on the 1h
forth day afte conception, The male
fetus ic exposed toa eltvely high
B days alter ith Teststrone Levels
then plummet, and remain Tow for
tout wo months, sng charpy again
ihe time of puberty (Fite 2
Thehgh ere etoteone present
inthe male during the ped before
tnd jut after birth has major conse
Geno I deni expert ths ale
Hormone elier Uvough feta surgery
toramowe the testes, ough pe
‘mecca eget that bck the oe
fl espns testosterone, he male
‘ivelopeanatoniely,physiogially
rd behaviorally asa fra
Intauterne Poston Etec
Inthe ealy 190s Bologats working
fm neurttansmiters inthe rt bra
dscovered that hormone evel during
‘eal development sre aso important
inthe establishment of variation bee
freen meer of the same soe Ly
trood Clemens and is laboratory
Toup st Michigan Sate University
Riedy dstngished newboen male
fe ema a pe Basso the di
{ince betwen fe as andthe gen
fae, Males have a longer anogenitat