GAUTAM BUDDH TECHNICAL UNIVERSITY, LUCKNOW

VARANASI COLLEGE OF PHARMACY, VARANASI

Printed Pages: 01

PHARM 472P

(Following Paper ID and Roll No. to be filled in your Answer Book)

PAPER ID:

Roll No.

ODD SEMESTER PRACTICAL EXAMINATION-2014-2015

B. PHARM-VII SEM (FOURTH YEAR)
SUBJECT: Biopharmaceutics & Pharmacokinetics
[Total Marks: 80]

[Time: 5 Hour]

1. Synopsis:
(10 Marks)
2. Experiments
(50 Marks)
(A) Major Practical: Perform dissolution test of the supplied marketed formulation.
(B) Minor Practical:
For even roll numbers
Plasma drug concentration of a patient (50kg, dose level of 6mg/kg, I.V. administration) at different
time interval is given below. Find Vd, Ke and t1/2 of the drug.
Time(Hr): 0.25
0.50 1.0
3.0
6.0
12.0 18.0
Conc. (g/ml):8.21 7.87 7.23 5.15 3.09 1.11 0.40
For odd roll numbers:
Following data were obtained from urine samples of a patient after IV dose of a drug. Find the Ke and
t1/2 of the drug by rate of excretion method.
Time (Hr):
0.25 0.50 1.0
2.0
4.0
6.0
Du (mg):
160 140
200
250
188
46

3. Viva-Voice

(20 Marks)

Name & Sign. of external examiner

Date:

Name & Sign. of internal examiner

Date:

VARANSI COLLEGE OF PHARMACY

END SEMESTER PRACTICAL EXAMINATION

SYNOPSIS, Subject:Biopharmaceutics & P.kinetics, PHARM 472P

TIME: 10 minutes,
Full Marks: 10
Write synopsis on the following topics.
1. Necessity of logarithmic conversion in determination of pharmacokinetic parameters.

2. Specific considerations for determination of Ka by Loo Riegelman method.

3. Generic drug and bioequivalence.

.
4. Significance of plasma protein binding of drug.

Name & signature of Internal Examiner

Date:

Name & signature of External Examiner

Date: