Generic name:

diphenhydramine hydrochloride
Brand name:
Benadryl
Preparations:
PO 25-50 mg q4-6 hr, 50mg 20-30 mins before bedtime
CLASSIFICATION: Antiparkinsonian drug
ACTION:
Antagonizes the effect of histamine at H1 receptor sites; does not bind or inactivate histamine
INDICATION / USES:
parkinsonism or drug-induced extrapyramidal effects

COMMON ADVERSE EFFECTS:

CNS: headache, fatigue, anxiety, tremors, vertigo, confusion, depression, seizures, hallucinations
CV: tachycardia, palpitations, orthostaic hypotension, heart failure
EENT: blurred vision
GI: dry mouth, nausea, vomiting, constipation, flatulence
GU: urinary hesitancy or frequency, urine retention
Hematologic: leukopenia
Skin: photosensitivity, dermatitis
CONTRA-INDICATIONS:
cardiac disease or hypertension
glaucoma
gastric or duodenal ulcers
NURSING CONSIDERATIONS:
Caution the client that the medication may cause drowsiness, creating difficulties or hazards or other
activities that require alertness.
Tell the client to take the medication with food to decrease GI upset.
Explain to the client that arising quickly form a lying or sitting position may cause orthostatic
hypotension.
When taking these medications, the client needs to have blood cells counts, renal function, hepatic
function, and blood pressure monitored.
Adverse effects of these drugs occur more commonly in elderly clients.
Explain to the client that use of these drugs in warm weather may increase the likelihood of heatstroke.