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    Reference Guide for the Foreign Pharmacy Licensing Exam er Perr health care delivery aok- Dik kako) spensing pharmacy administration health care economics Ue taste naan reign pharmacy by Manan H. Shroff, R.Ph Revised Edition Ssemerr seeeseeseeeseeseeeseesteeseeseeeseeseeeseeseeeeeereeeeeeeeeeeeeeeeeeeeeeeeerereeeeeeeeeeeeeeeeeeREEEEEEEEEEEE EE EEE Reference Guide for Foreign Pharmacy Licensing Exam Krisman Questions and Answers- 2nd Revised Edition TABLE OF CONTENTS SECTION-I QUESTIONS 7 SECTION-IT ANSWERS 121 SECTION-II TABLES 243 \www.pharmacyexam.com 6 Reference Guide for Foreign Pharmacy Licensing Exam Krisman Questions and Answers- 2nd Revised Edition 1 Benzyl alcohol is classified as: . Drug degradation d. Drug oxidation a. Emulsifying agent b. Preservative 7. Polymorphism is generally defined as ¢. Diluent a: d. Suspending agent a, Substance that may exist in more than 2. Cold cream is an example of: one crystalline form, a Suspension b. Substance that may exist only in meta- b. O/W emulsion stable form. c. W/O emulsion 4 OW/O emulsion ¢. Substance that has different viscosity time to time. 3. Egg yolk or egg white is used as: 4. Substance that reduces interfacial ten- a. Emulsifying agent sion. b. Suspending agent ©, Binder 8. The minimum concentration of a drug d. Preservative at the receptor site to initiate pharmacologi- cal action is defined as: 4. The transfer of a drug from high con- centrated areas to low concentrated areas is a. max generally defined as: b. MEC c. MTC a Infusion d ce b. Levigation ©, Diffusion 9. The area under curve gives useful in- 4. Dissolution formation about : 5. Which of the following is the most a. ‘The amount of drug systematically ab- suitable route for administration of insulin ? sorbed. a. IM b. The time to reach peak concentration. b Sc . ¢. The time to reach minimum toxic a IV bolus concentration. 6. Noyes Whitney equation is helpful to a. The concentration at which pharma- predict the rate of: cological actions of drug would be initiated. a. Drug diffusion b. _ Drugdissolution 10. Which of the following is the major plasma protein involved in drug binding? www.pharmacyexam.com a Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition a. Globulin b. Creatinine c 4. Albumin Glycoprotein 11. Which of the following equations may be useful to find out the plasma concentration of adrug ? a -V,xP=C, b- PxC,=V, c V,= PI, da V,=CyP 12. The initial dose of a drug through IV bolus to achieve desirable plasma concentra- tion at once is known as: Loading dose Maintenance dose Replacement dose Degradation dose 13. Which of the following is/are useful to measure glomerular filtration rate? 1 Creatinine i Inulin I, Albumin a Tonly b. Land Tonly cc. Tand IIT only a All 14. The rapid degradation of 2 drug by liver enzymes in a liver is defined as: Third pass effect of metabolism First pass effect of metabolism Rapid degradation Liver elimination eege www.pharmacyexam.com 15. Krisman The normal renal creatinine clearance value lies between: aege 16. 200 to 300 ml/min 80 to 120 ml/min 30 to 60 ml/min 10 to 20 ml/min Which of the following is an example of an oligosaccharide? eaege Glucose Sucrose Starch Glycogen 17. Which pyrimidine base is found only in RNA? aege 18. aege 19, Cytosine ‘Thymine Uracif Adenine Heparin is classified as a(n): Heteropolysacharide Oligosaccharide Homopolysacharide Monosaccharide Ribonucleic acid exists in all of the following forms EXCEPT : 20. 1 RNA mRNA. qRNA URNA Which of the following structures is a host for Kreb’s cycle ? a b. Mitochondria Golgi bodies Reference Guide for Foreign Pharmacy Licensing Exam ‘Questions and Answers- 2nd Revised Edition ¢. Cytoplasmic membrane d. Ribosome 21. The synthesis of glucose fromsources other than carbohydrates is generally known a. Glycolysis b. —_ Gluconeogenesis c. — Glycogenolysis d.— Glucogenesis 22. Which of the following amino acids should be considered an essential amino acids) for the body ? 1 Phenylalanine TL. Leucine MI, Tryptophan a. Tonly b. Land Ionly cand Ilfonly a Ail 23. Which of the following enzymes ca- talyses the coupling of two molecules of nucleotides to form DNA ? a. Transferase b. Ligase c. Isomerase d. Aldehyde dehydrogenase 24. A nucleotide is a building block of: a. Sphingomide b. Nucleic acid c. Amino acid 4. Starch 25. — Which of the following cells are in- volved with immune responses of the body? www.pharmacyexam.com Krisman 1. B lymphocytes I. — T lymphocytes Ill. Neutrophils a. Tonly b. Land Ionly ¢. Hand Ill only da All 26. — Which of the following immunoglo- bulin levels are elevated during asthma ? a IgM b. IgD c. IgE 4. IgA 27 Allof the following tests are required to check sensitivity of class A weighing pre- scription balance EXCEPT : a. Armratio test b. Rider graduated beam test c. Shift test da Utest 28. The ratio of the mass of an object measured in a vacuum at specific tempera- ture to volume (in ml) of an object at the same temperature is defined as: Absolute density Specific gravity Relative density Apparent density eege 29, — The mean blood pressure of Mr. Ham is: 01/01/00 80 mmhg 04/04/00 90 mm hg. 01/02/00 82 mmhg 01/05/00 85 mmhg 01/03/00 81.5 mm hg 01/06/00 83 mm hg Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition a BLS b. 85.6 c. 83.58 a 84.26 30. The deviation of data from its mean is generally described by: a, Theaverage b. The standard deviation c. The precision d ‘The accuracy 31. ‘The reproducibility of results of a number of experiments is generally known as a. Precision b. Bias c. Accuracy 4. — Closelessness 32. Ifthe value of p = 0.6 in binomial dis- tribution, what is the probability of failure ? a 02) be 04 Cn) a 10 33. The aterror is generally considered significant at: a, 1% bd 3% cof da 10% 34. — When the hypothetical value of a pa- the same as the observed value of a parameter, the error should be considered: a. Alfa-error b. —_Beta-error c. Gema-error a. Infinitive ‘www.pharmacyexam.com 35. Find out the degrees of freedom in a Chi-square testin a 2x2 contingency table (as- sume te: go sese segs 37. s are independent). RORe The F distribution generatly compares: ‘Two means ‘Two variances ‘Three means Three variances Which of the following elements has the highest electronegativity? eege 38. Which of the following molecules has the largest dipole movement? cH3 ca c. c CHB a FIGURE - I 10 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition CH3 H Nev a H CHB FIGURE-2 FIGURE-3 CHS ~ 4 ic F a c \ F FIGURE-4 a. Fig I b Fig c Fig iil ad Fig IV 39. Which of the following molecules has the highest boiling point? a HO b. .S c Hse 4 HCN 40. The bond between NH, and CO, is best described as a: www.pharmacyexam.com Krisman H oO a yo eege 41. Hydrophobic interaction force Ton dipole or jon induced dipole force London force Van der walls force The process of transforming a solid directly to a vapor state is generally defined Evaporation Melting Sublimation Levigation ‘The characteristic of solid substances toexhibit more than one crystalline or amor- phous form is defined as: aege 4B. Isomerism Polymorphism Zwitter ion Coupling Which of the following molecules rep- resents CIS form ? \ . a 7 ~ H cl FIGURE - I nu Reference Guide for Foreign Pharmacy Licensing Exam Krisman Questions and Answers- 2nd Revised Edition H c. Diffusion coefficient. 4. The length of the stagnant layer. a 46. Acetone is classified as a a. Polar solvent cl b. _ Nonpolar solvent c. Semipolar solvent 4. Dipolar solvent a 47 The process of degradation of ionic compounds into cations and anions in a pres- ence of water is defined as: va a. Solvation b. Hydration c Activation 4 Degradation 48. — What happens to the solubility of al- ee cohol as the molecular weight of alcohol in- i creases a FigI b. Fig II c Fig II a. Reduces ad. FigIV b. Increases c. Remain unchanged 4. Insoluble in wate 44, Which of the following drugs is an Insoluble in water angiotensin receptor antagonist ? Soe ae . light is classified as: a. Lisinopril b. Losartan c. Methyldopa & Oxidation 4. Captoprit b. Reduction cc. Photochemical degradation d. Racemization 45. — According to Fick’s law of diffusion, Which of the following is inversely propor- 54. The degradation of Penicillin G tionate to the rate of diffusion ? caine is highest in: a. The area of the solid. a. Solution b. The difference between the concentra- _ ae sion tion of solute to concentration of z a Tablet solute in stagnant layer. i www.pharmacyexam.com n Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition 51 Therate of oxidation is influenced by all of the following EXCEPT: a. Temperature b. Radiation c. Presence of catalyst 4. Hydrolysis 52. — Which of the following are character- istics of pseudoplastic flow? 1 Viscosity of the flow generally de- creases with an inerease in the rate of shears. Il —_Noyyield value has been found with flow. HL Suspension of tragacanth follows the pseudoplastic’s flow. a Tonly b. Land Il only c. Mand If only 4. 3, S.and iit only 53. Which of the following is NOT true about microemulsion? a. Themean diameter of a droplet gener- ally lies between 1010 200 nm. b Itisathermodynamically stable system. ¢ —— Itrequires a cosurfactant. 4. Itis intermediate in property between solution and emulsion. 54, — Asystem with considerable interaction between dispersed phase and dispersion me- dium is known as: eege Radioactive colloids www.pharmacyexam.com Krisman 55, Tobalance the following equation, how ‘many molecules of NH,Cl would be required? (NH)),S+NICI,—> NIS + NH,CL aes hens 56. Therandom motion of solute particles in colloidal dispersion is known as: Newtonian flow Brownian motion Stoke’s law Non-Newtonian flow pose 57. Which of the following about floccu- lated suspension is NOT true? a, Particles of suspension form loose ag- gregates. b. Rate of sedimentation is very low. ¢. The time to form sediment is less. d. The sedimentation is easy to redis- perse. 58. The rate of sedimentation is indepen- dent of : a. The viscosity of dispersion medium. b. The diameter of suspended particles. ¢. The difference in densities between dispersed medium and dispersed phase. The lipophilic nature of particles. 59. — Which of the following compounds is an acetanilide? CH,CONHC,H, CH,CHO. C,H,CHEN.CH, C.H.N=NCH, eege 13, Reference Guide for Foreign Pharmacy Licensing Exam ‘Questions and Answers- 2nd Revised Edition 60. |The spontaneous isomerization of two stereoisomers in aqueous solution that causes specific rotation is known as: a, Zwitter ion rotation b. Micelle rotation c, Mutarotation 4, Steriorotation 61. Which of the following is a polysae- charide? a. Dextrose b. Dextran c. Lactose d. Sucrose 62. The susbstance that is isolated from the brain and produces fatty acid, galactose and sphingosine upon hydrolysis is known as: a. Sterols b. Phospholipids c.— Glycolipids d—— Saponins 63. Which of the following is NOT a by- drolyzed product of Jecithins? a Fatty acid b. Glycerol c. Phosphoric acid d. — Spingosine 64. N H CH.NHCOOH NH www.pharmacyexam.com Krisman Which of the following is anactive moiety of the above compound ? a. Carboxylic acid b. Imidazole e. Pyroline 4 Aniline 65. Albumin is an example of a: Simple protein Conjugated protein Derived protein Hydrolysed protein NH a | Ty Fluorination ( NH ° Fluorination of above compound will result into a well known cancer drug known as: a. Methadone b, — S-fluorouracil ¢. 6-mereaptopurine 4. Procainamide 67. For microbial assay of vitamin B-12, the test organism should be : a, Leichmani b.— Lplantarum c. aeruginosa 4. S.pneumonia 68. — Which of the following isNOT classified asa titrimetric method of analysis? a, Directtitration b. Gravimetric titration ©. Complexation reaction d.— Redox reaction 14 Reference Guide for Foreign Pharmacy Licensing Exam. ‘Questions and Answers- 2nd Revised Editi 69. Hemolytic anemia with abnormai he- moglobin is generally found in patients with : Vitarnin B-12 deficiency anemia Sickle cell anemia Iron deficiency anemia Folic acid deficiency anemia aege 70. Allof the following drugs may cause hemolysis in a patient with G6PD deficiency EXCEPT: Chloroquine Sulfonai Dimercaptrol Penicillin aoge 71. Which of the following drugs is use- ful in a Rh negative mother with a Rh posi- tive infant ? a, Rhogam b. — Octeroide acetate ¢. Immunoglobulin 4. Pheu-immune 72. — Which of the following is NOT true about PKU ? a. Ttisadisease usually characterized by ‘mental abnormalities. b. high concentration of phenylpyruvic- acid is found in urine, c. _Itoccurs due to excessive secretion of Phenylalanine hydroxylase enzyme. 4. A guthrie test is normally performed todetectiit. 73. The metabolite product ofepinephrine and norepinephrine is : a. Gama butyric acid b. —_Vanillymandelic acid cc. Homovanillic acid d. 5Hydroxyindoleacetic acid www-pharmacyexam.com Krisman 74, — Which of the following is ananaerobie organism? a, L. pneumonphllia b. Cl. tetani ©. N. meningitis d. E. coli 75. Which of the following organisms is responsible for causing most of the UTI? aS. pharyngitis 6. E.coli ¢. _N.gonorthea 4. T. palladium 76. The accurate diagnostic test for a pa- tient with cystic fibrosis is : a. Mantoux test b. Sweat test c. Breath test a. Sick test 77. ‘The allergic skin reaction character- ized by wheel formation is known as: a. Eczema b. Urticaria c. Impetigo a Exythema a. Itisadisease usually characterized by polyuria, polydypsia, and severe thirst. b. The urine volume sometimes increases 16 to 24 liters a day. c. This thought to occur due to over- activity of ADH. 4. A patient should be monitored for dehydration. 15 Reference Guide for Foreign Pharmacy Questions and Answers- 2nd Revised Edition 79. inwhich kinetic reaction is the rate of re- action independent from concentration ? a. First order b. Zero order c. Pseudo first order 4. Second order 80. The initial degradation of a drug by liver enzymes after oral administration of the drug is known as: Enzymatic degradation First pass metabolism Relative bioavailability Fick’s degradation aoe 81. Which of the following factors DOES. NOT affect the protein binding of a drug ? a. Theavailabitity of protein for binding. b. Binding affinity of protein to the drug. c. The presence of competing substances for protein binding. 4. The concentration of a drug at its receptor site. 82. In which of the following conditions is an increase in plasma protein albumin found 2 a, Severe burns b. Cystic fibrosis c. Trauma 4. Hypothyroidism 83. — Which of the following drugs is an H, re- ceptor antagonist ? a. Hydroxyzine b. Cimetidine . Diphenhydramine 4. Omeprazole ‘www.pharmacyexam.com nsing Exam 84, Whichof the following dugsis indicated forreducing elevated blood concentration of ammonia in blood ? a. Lactulose b. _Diphenoxylate c. Sueralfate 4 Calcium polycarbophill 85. Patients with hemophilia have a defi- ciency of a. Rhol) b. AHF c. ADH da ACE 86. Sodium polystyrene sulfonate is found to lower: Serum K* concentration Serum Na‘ concentration Serum Al" concentration ‘Serum Ca‘? concentration aoge 87. Which of the following cells are gen- erally found to be elevated in a patient with polycythemia vera? Reticulocytes Erythrocytes Leukocytes Thrombocytes Bose 88. Which of the following antihypertensive drugs acts by blockingalfa-I receptors? L Doxazosin ‘Terazosin I Prazosin Tonly Land Il only Hand Ill only 1,11, and If only eege 16 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition 89. Which of the following receptor's stimu- lationprevents the release of noradrenaline? a Alpha-I receptors >» Beta-) receptors cc. Alpha-2 receptors d. Beta 2 receptors 90. — Hypertrichosis is generally associated with the use of a. Hydralazine b. Minoxidil c. Methyldopa 4. Clonidine 91. The preferable route for Sodium Nitroprusside is a. Intramuscular b. Oral cc. Intravenous 4. Subcutaneous 92. An overdose of sodium nitroprusside generally causes a, Severe hypotension b. Hypertension c. Renal failure d. Severe edema 93. The use of Sodium Nitroprusside should be strictly restricted by a Adult men. = Adult women c. Neonates d. ‘Children 94, Whichofthe following hypertensive drugs is known as aninodilator ? www.pharmacyexam.com Krisman a. Nitroglycerin b. — Milrinone c. 4 Dipyridamole Digoxin 95, — Which of the following is a Class-1A arrhythmic agent ? a. Lidocaine b. —_Procainamide c. Encainide 4. Atenolol 96. Which of the following blood cho- lesterol lowering drugs is an HMG-COA in- hibitor ? Gembifrozil eege 97. A patient with acute hypercapnia should be treated with which of the following Doxapram Dopamine Disopyramide Ipecac 98. Which of the following drugs is found to be mucolytic or reduces the viscosity of mucous ? a. Dextromethorphan b. — Acetylcysteine cc. Terbutaline 4. Benzonatate 99. Which of the following drugsis indicated as uterine relaxant for women in labor ? Ephedrine b. ‘Terbutaline 17 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition cc. Isoetharine d.— Metaproterenol 100, Which of the following is an atropine - like drug? Retrovir Ipratropium Carvedilol Latanoprost aege 101, Which of the following is a centrally acting muscle relaxant ? a. Dantrolene b. Cyclobenzaprine c. Bromocriptine 4. Amphetamine 102. Which of the following anti- Parkinson’s drugs is a dopamine receptor ago- nist? a. Carbidopa b. — Benztropine ¢. Bromocriptine 4. Amantadine 103. Which of the following diuretics acts through inhibition of carbonic anhydrase en- zyme? a. Furosemide b. — Acetazolamide Spironolactone 4. Hydrochlorothiazide 104, Which ofthe following isa common ad- verse effect of metolazone? a Seizwe b. Electrolyte loss c S.LE. @—_Neuroleptic malignant syndrome www.pharmacyexam.com Krisman_ 105. Which of the following diuretics cause hyperkalemia when used concurrently with Captopril ? L— Amiloride IL Spironolactone I. Triamterene Tonly Land Il only Tl and Il only 1, U1, and IIT only eege 106. Probenecid may competitivety inhibit the renal tubular secretion of : - Methicillin Methotrexate UL Dapsone Tonty Land I only Mand I only J, U, and Ut only nore 107. Which of the following can be admin- istered for treatment of insulin overdose ? 1. Glucagon UW. LV. Dextrose UL. Lidocaine a Tonly b. and Ionly ©. and IlTonly 4. L,MandIiTonly 108. Which of the following sulfonylurea ‘agents is indicated for the treatment of diabe- ‘es insipidus? a, Glyburide b, —Chiiorpropamide ©. Glipizide 4. Tolbutamide 18 Reference Guide for Foreign Pharmacy Licensing Exam Krisman Questions and Answers- 2nd Revised Edition 109. The deficiency of vitamin A may cause a Osteoporosis b. —Nightblindness cc. Scurvy 4. Anemia 110. Which of the following can be used for the treatment of Methotrexate overdose ? a. Mephyton b.— Leucovorin Ca*® c. Pyridoxine a Niacin J11. Which of the following benzodiaz- epines can be safely administered to a geriat- ric patient ? a. Chlordiazepoxide b. Alprazolam .— Oxazepam 4. Prazepam 112. The active metabolite of Primidone is L Phenobarbital I. PEMA I. Trimethadione a Tonly b. Land Ionly c. and Ill only 4 I, I,and IT only 113. Which of the following drugs should not be used with Fluoxetine? a, Tranylcypromine b. Digoxin Amitriptyline d. Lidocaine www.pharmacyexam.com 114. Which of the following is not classified as an insect control chemical ? a. Insecticides b. Repellents ¢. Attractants 4. Antiseptics 115. Which of the following is NOT true about Barium sulfate? a. Itis medicinally used in roentgeno- graphy for the examination of the stomach and colon, b. _ Itisa clear solution, cc. Theprinciple adverse effectis constipation. 4d. _Ttneeds tobe mixed well with food or strained through gauze before it is administered to a patient. 116. The addition of Ascorbyl palmitate in the manufacturing process serves as a a. Preservative b. Antioxidant ©. Coloring agent 4. Flavoring agent 117. Epinephrine hydrochloride solution can be stabilized by adding a small amount of a. Sodium metabisulfite b. Sodium bisulfite c. Sulfur dioxide d. Potassium benzoate 118. Which of the following are classified as certified colors? I FDandC I. = Dand MM. External DandC 19 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition a Tonly b. Land only ce. Mand Mlfonly dL, Tand Ill only 119. Which of the following isnot considered aprimary taste? a Saline b. Sweet ©. Spicy da. Bitter 120. A 500.mg dose of a drug administered via LV. injection produces a plasma concentra- tion of 2.5 meg/ml after 16 hours. Ifthe initial plasma concentration of the drug is 10 meg/ml, bioavailability is 1,and volume of distribution is 120,000, what is the half-life of the drug? a 2hours: b. Bhours ce. Shours d.15hours 121. Sweet taste of acompoundis generally attributed to: Presence of Htions Presence of OH ions Presence of cations and anions Presence of alkaloids ees 122. The alcohol content of low iso-alco- hol elixir is : 8t0 10% 15 to 23 % 50 to 80 % 73 to 78% pe oe 123. Erythema muttiform is generally de- scribed as: www.pharmacyexam.com Krisman a, Thepresence oferythematous macules and papules. b. The presence of hair on skin ©. ‘The presence of large flaccid bullae on. skin, 4. The presence of scaling and sloughing on entire skin. 124. The antidote for Acetaminophen tox- icity is: a EDTA b. — Neacetyleysteine cc. Mesna 4. Diazepam 125. Which of the following drugs may cause cholestatic jaundice? [Chlorpromazine Il. Erythromycin estolate TI. Indomethacin Tonly Land II only Mand III only 1, IL, and III only pege 126. The principal adverse effect of Clinda- mycin is: a ARF (acute renal failure) b&. TEN (toxic epidermal necrolysis) ¢. AAC (antibiotic associated colitis) d. ADR (adverse drug reaction) 127. Which of the following is a major adverse effect of Chloramphenicol? a. ‘Thrombocytopenia b. Aplastic anemia . Hemolyticanemia 4. Agranulocytosis Reference Guide for For Questions and Answers- 2nd Revised Edition 128. Which of the following drugs mayNOT cause hemolysis in patients with G6PD deficiency? a Quinine b. —Sulfonamide c. —Nitrofurantoin d. Erythromycin 129. Ringing or buzzing in the ear is asso- ciated with : a, Streptomycin b. Salicylate c. Methyldopa 4. Minocycline 130. Pigmented retinopathy is highly asso- ciated with a. Chlorpromazine b. — Thioridazine ec. Clozaril 4. Haloperidol 131. Which of the following drugs is asso- ciated with pulmonary dysfunction ? 1. Bleomycin I. Amiodarone MI, Nitrofurantoin a Tonly b. Land Ionly cc. and If only dM, and [ff only 132. Which of the following phase trials includes extensive clinical tials ina human? I. Phase TIlonly TL. Phase I only I. PhaseTonly www.pharmacyexam.com ign Pharmacy Licensing Exam a Tonly b. —_TandIonly Hand Ilfonly 4. L.I,and only 133. When structurally different chemicals produce the same clinical results, itis generally defined as: ‘Chemical equivalence Bioequivalence ‘Therapeutic equivalence Clinical equivalence aoge 134, The parameter that is generally NOT included in evaluating the bioegivalency of ‘two or more formulations of the same drug is Peak height concentration. Concentration at receptor site. Time to reach peak concentration. AUC. apse 135. A substance that kills microorganisms but not bacterial spores is generally defined as: a. Bactericide b. Sterility c. — Germicide d. Disinfection 136. How many grams of Heparin is re- Aired to prepare I quart of 0.45% solution ? 2.21 grams 5.56 grams 4.32 grams 3.15 grams 137. Which of the following about moist heat sterilization is NOT TRUE? a Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition a, _Itisawidely used method for sterl- ization of mineral oil, greases and waxes. b. The cause of death of organisms is generally attributed to coagulation of cellular proteins of organisms. c ‘The substance should be kept loose. to allow direct penetration of steam. d. The substance should be kept at least 15 minutes under pressure steam at a minimum of 12i° temperature. 138, Which of the following gases are gen- erally implied forsterilization of pharmaceu- ficals? 1 Bthylene oxide IL Formaldehyde I. — Sulfur dioxide a. Tonly b. Land I only c.— Tand Il only 4. 1, Hand {Ml only 139 How many ce of 75% alcohol is re- quired to prepare 35% of 500 cc of alcohol ? (You have 10% of 1000 cc of alcohol in stock.) a —-192.30ce b. — 200cc ce. 450ce d. 325.55ce 140. How many tablets (approximately) of 0.125 mg Lanoxin is required if the measured. plasma concentration of drug is 1 meg/ml and the desired plasma concentration of drug is 1.5 mcg/ ml. The apparent volume of digoxin is }OL/Kg for a 70 kg patient. (Assume S and F= 1) a One. b. Four ce. Three a Two www.pharmacyexam.com Krisman 141. Sterilization by U.V. radiation generally requires a wavelength of: a 320 nm b .253 nm e150 nm 4 475 nm 142. If i teaspoon of Thioridazine intense solution (30 mg/cc) is diluted up to the 480 ce mark with plain water, what would be the strength of the drug in mg/m) in the final so- lution ? a 1 mg fcc b. 0.52:mg /ec ©. 031 meee 4. 0.75 mgiee 143. Which of the following tests are used to identify Laminar flow efficiency and qual- ity of sterilization? 1 Smoke test I. Doptest Hil, Microbial test a. Tonly b. Land ITonly {and If only 4. LU and ttt only 144... The rate of hydrolysis depends on 1 Pressure I pHofthesolution T. — Temperature a. Tonly b. — LandITonly Mand Ilfonly 41, Hand itt only 22 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised E 145. If 1000 iablets of Risperdal 1 mg cost ‘\— $2250, and the mark-up on prescriptions is 20%, ‘what would be the retail price of 30 tablets’? $150 $i7 $500 $81 ees 146. NH2 1H2 Ue —Q COOH ‘OH (P-Aminosalicylic acid) _(m-aminophenol) The formation of m-aminophenol occurs due to : a. Oxidation of p-aminosalicylic acid. b. _ Decarboxylation of p-aminosalicylic acid. c. Reduction of p-aminosalicylic acid. 4. Hydrolysis of p-aminosalicylic acid. 147. According to the International Phar- maceutical Federation, the maximum percent- age of overages is limited t0 : 10% of over the labeled potency. 20% of over the labeled potency. 30% of over the labeled potency. 40% of over the labeled potency. eos 148. At what concentration doessucrose re- tard the growth of microorganisms. = 20% wiw b. 30% wiw 65% wiw a 85% wiw www.pharmacyexam.com 149. Krisman ‘Which of the following best describes the Ingram’s regimen? a. Combination of anthralin + UVA b. Combination of coaltar + UVB cc. Combination of anthralin + UVB 4. Combination of psoralen + UVA 150. Which of the following drugs is indi- cated for treatment of eystic fibrosis? a. Domase Alfa b. Calcitonin salmon ©. Acetazolamide d. Methotrexate 151. Find out the ratio of ionized to union- ized species of a drug at pH =7. The pKa of the drug is 5 a 100:1 b.50:1 ce 25 a 200:1 152. Ocusert Pilo 20 generally delivers 20 meg of Pilocarpine per hour for 7 days. b. 20 mg of Pilocarpine per hour for 7 days. ¢. 20 meg of Pilocarpine per hour for3 days. 4. 20 mg of Pilocarpine per hour for 3 days. 153. Which of the following antiglaucoma medications has aCabonic Anhydrase Enzyme inhibition property? a. Timolol Db. —_ Dipiveftine 23 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition .— Dorzolamide 4. Latanoprost 4154, If a dropperiscalibrated to deliver 325 mg of iron sulfate per 0.6 cc, and the adult dose of the drugis 325 mg, what would be the dose of drug in cc required for a 15 month old infant . a Lec b. 03 cc c. 0.06 cc d 0.01 cc A155. Which of the following is/are true about Triphasic oral contraceptives? 1 Triphasic affects the follicular, ovula- tion and luteal phases of the menstrual cycle successfully and provides more favorable effects than biphasic and monophasic. TI Itis generally formulated with low progesterone content. TI. The principal advantage associated with Triphasic is the uniform direction for taking the pills. Tonly Land Il only Mandl only 1, Mand IJ only pege 156. Which of the following phase(s) is/are generally dominated by estrogen ? 1. Follicularphase I, Ovulatory phase IIL. Luteral phase a. Tonly b. —_TandIlonly www.pharmacyexam.com Krisman c. MandIIllonly 4. Mand Uf only 157. Which of the following about Metabolic Acidosis is NOT TRUE ? a. It generally occurs due to loss of bi- carbonate from the body. b. _ Hypokalemia is generally a result of metabolic acidosis. ¢. Administration of Arginine HCl gen- erally resolves metabolic acidosis. 4, It stimulates the respiratory center to increase excretion of CO, from the body. 158. Which of the following ingredients acts as a contact poison that disturbs the Parasite’s nervous system? a Lindane b, _Permethrine c, — Pyrethrin 4. Pyrimethamine 159, Which of the following is a cough ex- pectorant? a Guaifenesin b. —Dextromethorphan ¢. Benzonatate 4. Diphenhydramine 160, HbA, 6% value indicates : 80 mg/dl blood glucose 120 mgi/dl blood glucose 360 mg/dl blood glucose 160 mg/dl blood glucose Reference Guide for Foreign Pharmacy Licensing Exam. ‘Questions and Answers- 2nd Revised Edi 161. How many milliequivalents of Ferrous Sulfate are present in 325 mg of Ferrous sul- fate 2(Molecular weight = 151.85 gr/mole) 5.6meq 10.12 meq 7.5 meq 4.28 meq aoge 162. Which of the following adverse effect(s) is/are associated with insulin therapy? 1. Hypoglycemia IL _Lipoatrophy IIL. _Lipohypertrophy a Tonly b. and Monly ¢.— Tand Ill only 4. [Mand If only 163. Acarbose is contraindicated for pa- tients suffering from 1. Inflammatory bowel disease II Patients with colonic ulceration III. Patients with intestinal obstruction a Tonly b. Land ILonly cc. Tand Ill only @ [Mand Ill only 164. Which of the following isNOT asymp- tomof hypoglycemia? Confusion Bradycardia Difficulty in concentration ‘Sweating pose 165. Whichofthe following diabetic drugs pro- duces disulfiram reaction with alcohol? www.pharmacyexam.com Krisman a. Acarbose b. _Chlorpropamide cc. Metformin d.—_Repaglinide 166. Normal threshold value for glucose inthe kidney is a. 100 mg/dl b. 120 mg/dl cc. 180 mg/dl 4220 mg/dl 167. How many mEqs of Na’ are present in \/ 0.9% 250 ce solution of NaCl ? {equivalent weight of NaCl = 58.5] a 50.5 mEq b. 38.5 mEq c. 225 meq d. 585 mEq 168. Which of the following is NOT rec- ‘ommended to treat hypoglycemia induced by Acarbose ? Dextrose Table sugar Glucagon Glucose eer 169. | Whatis the half-life of a drug that has a rate constant of 0.067 days” in first order kinetic ? a Sdays b.-7.23days ©. 10.34 days 4. 12.51 days 170. Which of the following isNOT TRUE about Vancomycin HCl? 25 Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition a, Nephrotoxicity and ototoxicity are ‘comtian complications of therapy, b. IV Vancomycin is indicated for treat mentof antibiotic associated coli c. When taken orally, itis poorly absorbed from the GIF. 4. Ttisavailable in oral solution, pulvules 4nd injection form, 171. Which of the following drugs shoutd patients with hypertensensitivity to Me- salamine avoid ? 1 Sulfasalazine TL — Olsalazine It. Mesalamine a, Tonly b, Land only ©, Mand If only 4 Eitand {ff only 172, Which of the following is NOT a sign of Grave’s disease? 4 Fast heartbeat b, Weight gain a Soft skin d. High basal metabolic rate 173, Which of the following is/are caused by thyroid hormone deficiency ? 1. Myxedema M— Cretinism Ml, Grave's disease a. Tonly b. Land Il only © Mand Ilfonly 4 I,Mand Mf only ‘www.pharmacyexam.com Krisman 174, Which of the fottowing thyroid drugs should in pregnant women avoid ? Propylthiouracil Methimazole Propranolol Levothyroxine eee 175, Which of the following statements about thyroid supplements islare true? I. _Livothyronine is associated with head- ache, palpitation, tremor and diarrhea, and is less recommended for treatment of hypothyroidism. I. Desiccated thyroid preparations have a variable T3 to T4 ration and are less recommended by physicians. IIL Levothyroxine is the most recom- mended thyroid supplements. Tonly Land IT only Mand I only J, Wand Wi onty eo se 176. Which of the following drugs is indi- cated in smoking cessation programs ? a. Bupropion b. Tramadol cc. Tamsulosin 4. Risperidone 177. Which of the following drugs inhibits the aggregation of platelets ? 1. Ticlopidine HCL IL Aspirin Il. Clopidrogel Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition a Tonly b. Land Ionly c. Hand Mfonly d. I, Mand If only 178. Which of the following drugs mobilizes bone calcium into blood ? Estrogen Calcitriol Calcitonin Salmon Alendronate Na apse 179. Diphydrotachysterol is indicated for treatment of 1 Tetany I Idiopathic Tetany II. Hypoparathyroidism Tonly Land I only Tand Il only I, Mand III only aege 180. Which of the following is NOT a sign of Morphine overdose? a, Cold and clammy skin b. Respiratory depression c. Pupil dilation 4. Convulsions 81. How long will it take to decompose Lanoxin in elixir to one half of its original concentration in an order that is first order kinetic ? [ K = 0.023 min} a. 40.45 minutes b. 50.60 minutes c. 75.80 minutes d. 30.13 minutes 182. Which of the following glasses are most chemically resistant or least leachable? www.pharmacyexam.com Krisman a, Type borosilicate glass b. Type ITsodalime treated glass cc. Type III sodalime glass d.—TypelVglass 183. According to Federal standard, class 100 clean room is generally defined as a, Not more than 100 people working in room. b. Not more than 100 particles per cubic ft of 0.5 mom or larger size. c. Not more than 100 bacteria per cubic ft of 40 mem or larger size. 4. Not more than 100 viruses per cubic ft of 40 mem or larger size. 184. Which of the following isNOT TRUE about a HEPA filter ? a. It is generally described as a high effi- ciency particulate air filter. b. thas anefficiency of removing 100% of particles 0.3 mem or larger. c. A Dioctyl Phthalate test (DOP) generally finds outthe efficiency of HEPA filters. 4. __Itisuseful forthe preparation of parenteral products. 185. Cold sterilization of parenteral solution is defined as: a, Removing 2 memorlarger par- ticles from the solution. b. Removing 0.2 mem or larger par- ticles, including microorganisms, from the solution. Pa Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers- 2nd Revised Edition ©. Sterilization of the parenteral solution with hot and cold compresses. 4. Sterilization of he parenteral solution by freezing the solution below freezing point 186. Lyophilization is defined as: 2. The removal of water by method of sublimation from the product after it is frozen. b. Direct evaporation of a substance from its solid form. c. Preparation of colloidal solution, 4. Removat of particulate matter by fil- tration. 187. Which of the following is NOT de- scribed as aquality assurance and control test for parenteral solution? Sterility test Particulate matter evaluation Pyrogen test Schilling test pegs 188. Which of the following isNOT anon verbal communication? a. Body posture b. Facial expression ¢. Open-ended question 4. Distance of the patient 189, Staff model HMO organizations gen- erally own: L Healthcare facilities TI. Employed physicians II, Nonemployed physicians www.pharmacyexam.com a. Tonly b.— Tand only ¢. Hand!lfonly 4 [Mand ifonly 190. ‘The disadvantage associated with mail- order pharmacy services are : L Alack of pharmacist counseling. I, Allack of review of patient’s pro- file. II, ‘The use of recycled prescription drugs. a Lonly b. Land II only Wand {fl only 4 I, Tand Hit only 191. Which of the following best describes the prospective payment system? a. Reimbursement to the hospital based on cost incurred during hospitalization. b. Reimbursement o the hospital in ad- vance, with a specific rate based upon diagnosis of patient. ¢. Reimbursement to hospital by patient when he/she i discharged. 4. Prescription purchased by patient by paying cashs. 192. Most hospital pharmacies generally

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