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Pathophysiology

Type 2 Diabetes Mellitus

Genetics

Intracellular
Hypoglycemi
a
Glucogenesis
and
Gluconeogenes
is
Breakdown
of fats
High
levels of
ketones
Diabetic
Ketoacido
sis

Insulin
Insufficiency

Obesity

Reduced
tissue uptake
of glucose

Extracellular
Hyperglycemia
Hyperosmot
ic plasma

Decreased
Protein
Synthesis
cachexia
lethargy
polyphagia
Decreased
Gamma
Globulins
susceptibility
to

Dehydratio
n of cells
Hyperglyce
mic coma

Blood
glucose
> renal
threshol
d
glucosori
a
Osmotic
diuresis
-polyuria
-polydipsia
-hypokalemia
hyponatremi
a

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