Inhibitors of Viral Neuraminidase

Zanamivir and Oseltamivir

Mechanism of action
Zanamivir and oseltamivir inhibit viral neuraminidase, an enzyme
essential for release of newly formed virus particles
from infected cells and further spread of the infectious virus.
Clinical use
Zanamivir and oseltamivir are effective for reducing the duration
of influenza A and B if administered within 48 hours
of symptom onset and may prevent viral infection in close
contacts of affected individuals.
Adverse effects
Oseltamivir is not recommended in infants younger than
1 year because of fatalities in mice. Zanamivir should be
avoided in those with asthma or chronic obstructive pulmonary
disease because it can cause bronchospasm