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PATHOPHYSIOLOGY:

Destruction of dopaminergic neuronal cells in the substantia nigra in the basal ganglia

Depletion of dopamine stores

Degeneration of the dopaminergic nigostriatal pathway

Imbalance of excitatory (acethylcholine) and inhibiting (dopamine)


neurotransmitters in the corpus striatum

Impairment of extrapyramidal tracts controlling complex body


movements.

Tremors

Rigidity

Bradykinesia

Postural changes

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