LOOMI ESSENTIALS OF Toxicology SoC Stee ti KonN] ‘anestrus este Sorta apse scone al (GairaiTa wrasse otinmarce tbo ‘Seo ant ye npn Gena mai ‘Stem dma sy ea he Fre cel cal er ant ‘pales Adame oe ‘Givin nc sayon tcl coat oct ‘Sil eee dg yp of ae Sa ata et ape tn ‘ne cr i el oe eu exo map er te ‘svt a a oe 2a een ea mae 132 stat oman ‘Reishi Hono ot os to ‘Crp ee he set wy ad ho tbe or tt pemie bt cespeygeseuanat| {icp ony er ti oe ei of i Ta, ‘yea ent ae leo wi Sosy siesta ‘el md ne pps il ce el ‘a aie poly ae ‘ht ett et ay tl ee ‘ainsi le eo we ‘rota ams exible ‘eiesteas Titre en ge Cte te wee pss al ‘ea ean ce po ‘Bost npc eet nce aeene Os] ACUTE DRUG ABUSE EMERGENCIES AULA NINN OI Fcited by Peter G. Bourne, MD. MeTioo OF ERtC G. comsrocK 28 morbidity excerds the benefits and stimulant drvge no fongst have # fol ta the treatment of severe sedative drug Srerdoze, Pernsting AS¥o- ‘acy of stimulant drupx has not been eliminated from the literature and Rich recommendations shoud bbe viewed a2 mot im accordance with ‘Sound eerrent concepts of treatment of sedative drug orerdove ‘Somme substances recommended widely in the older literature have tees replaced with others Which perform the tame role more safely ot mare effectively. Potassium permanganate solution 1/5000 has been AGvocated for years a1 1 solution to be ised in gastric lavage fo inactivating alkaloida! substances by oxidation. Potassium permanes sate is survne onidtsing agent ‘which comnet difterentinte alkaloids from body tamer Recent vestigations have shown subject to inactivation By oxidation also are adsorbed ‘etirated charcoal, thereby preventing bisaralabdity cosl is a sate and effective substitute of potassium peimanganats Solutions recommended for gasteis lavage (Hayden, 1978) ‘A prepamtion called Antidote” conta ad songeesiunt oalde is commervialiy evedisble end iy alwocated for use im partic lavage. Recent investips- tions hare shows that the “Universal Ansidote” it bess effective in feducing bioavailability than it activated charcoal alone {Picchlonl, Yo66), Activated: charcoal suspension should replace the ‘Chematherspy for drag abuse related emergencies is in a continuous sate of flux. Refetences for treatment methodology should be Updated Potiodically so that the level of care provided these patients will be Consistent with best currently available medical practices, 1H Chemotherapeutic Approaches. A. Bimertes Emetics are used conisioaly to empty the stomach of its contents eduction of vomiting may prevent or reduce ihe severity of posonine by removing tonic substances prior fo thels abearption. Alter signs oF ssmptoms of pouosing occur, emesis should mot be induced. Emexis is Considered dangmeus thea corvesive slkall or strong acide have born Ingested: inchiction of emeris should not be attempted bf there is central nerves syvtem deprenion because of the increased incidence of api Hon pastmonia and decreases efficacy of centrally acting emnetics Ordinarily Induction of emesis {8 an available option within only 22° Nour sl ingestion. ‘The relative setts Of emeais ax compared wath