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TableS1:Examplesofmultistatemodelsofbiologicalsystems

Biologicalsystem

Specification

Computation

Reference

Bacterialchemotaxis
signalingpathway

StochSim

StochSim

[61]

CaMKIIregulation

StochSim

StochSim

[27]

ERBBreceptor
signaling

BioNetGen

NFSim

[29]

Eukaryoticsynthetic
genecircuits

BioNetGen,PROMOT
[62]

COPASI[63]

[30]

RNAsignaling

Kappa

KaSim

[64]

Cooperativityof
allostericproteins

AllostericNetwork
Compiler(ANC)

Matlab

[6]

Chemosensingin
Dictyostelium

Simmune

Simmune

[44]

Tcellreceptor
activation

SSC

SSC

[65]

Humanmitotic
kinetochore

BioNetGen

SRSim

[66]

Cellcycleoffission
yeast

MLRules

JAMESII[42]

[41]

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