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CONCLUDING REMARKS

The foregoing review has hopefully shown that the


biosynthesis of the ergoline ring system, which at one
time looked like a simple sequence of mostly non-specific
reactions, involves a substantial number of very specific
and rather complicated transformations. It has also

Medicinal Chemistry and Pharmacognosy, particularly Professors


J. M. Cassady, C.-j. Chang, P. F. Heinstein and J. E. Robbers, and
with a number of other research groups, particularly that of
Professor D. Groger, Halle (Saale), to all of whom I am greatly
indebted. Finally I want to thank Mrs. Lorraine Smith for her
skill and patience in typing this manuscript and drawing all the
structures.

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