White multifocal lesions in rabbit livers

This type of lesion can be associated with different causes, the first two are the most
common:

CAUSE
Coccidiosis

PATHOLOGY
Hyperplasia and bile
ducts fibrosis.

DIAGNOSTIC METHOD
Histopathology: microscopic
observation of coccidia.

(Eimeria Stiedae)
Stool Analysis.
Parasitic migration

Migration paths.

(Taenia pisiformis)

Granulomas.

Salmonellosis

Focal hepatic necrosis.

(Salmonella typhymurium,
Salmonella enteritidis)
Tyzzer Disease

Focal hepatic necrosis.

Histopathology
Warthin Starry staining.

Focal hepatic necrosis.

(Lysteria monocytogenes)
Myxomatosis

Histopathology
Culture with special enrichment
methods.

(Clostridium piliformis)
Listeriosis

Histopathology

Histopathology
Bacterial culture.

Focal hepatic necrosis.

Histopathology

Focal hepatic caseous

necrosis.
Focal hepatic caseous
necrosis.

Histopathology Zhiel Neelsen

staining.
Histopathology

Poxvirus
Mycobacterium
Pseudotuberculosis
(Yersinia pseudotuberculosis)
Coronavirus
Neoplasia
Lymphoma

Bacterial culture.
Focal hepatic necrosis.

Histopathology
Histopathology

Uterine carcinoma.

Whitish multifocal lesions. Histopathology could not determine the cause. The
microbiological culture was negative, even when pre-enrichment for Salmonella was used.
Warthin Starry and Ziehl Neelsen staining did not show the presence of Clostridia nor
Mycobacteria. A RFLP study was conducted to detect the presence of pathogenic bacteria
witha negative result. The chronic nature of the lesion may prevent the detection of the
causative agent.

In this occasion the whitish lesions corresponded to hyperplasia and bile ducts fibrosis due to
the presence of coccidia (Eimeria stiedae).

Photomicrograph of an Hematoxylin-eosin staining . Bile duct hyperplasia can be observed as

well as periductal inflammation and fibrosis (asterisk) and the presence of protozoal
structures inside the ducts and the epithelium (arrows). Top left extended.