Wedelia biflora (L.

) DC

Tng quan

Chng 1. TNG QUAN

1.1. C TNH THC VT
Trong cc cy h Cc (Asteraceae), gm 70 loi cy thuc chi Wedelia,
trong mt s cy c bit n Vit Nam [1, 4, 5, 6] nh:
Sn cc hai hoa - Wedelia biflora (L.) DC.
Sn cc nhm - Wedelia urticaefolia (Bl.) DC.
Sn cc b - Wedelia chinensis (Osb.) Merr.
Sn cc ba thy - Wedelia trilobata (L.) Hitch.
Si t - Wedelia calendulacea L.
L a cc - Wedelia prostrata (H. & A.) Hemls.
1.1.1. Cy sn cc hai hoa - Wedelia biflora (L.) DC. (Hnh 1.1a)
Cy Sn cc hai hoa c tn khoa hc l Wedelia biflora (L.) DC. [1, 5].
Sn cc hai hoa cn c gi l cc mt tri, rau mui, hi cc.
Dng cy bi, cao 1-2m. Thn c lng cng, tha. L c phin xoan xoan
tam gic, c t lng nhm nhm. Hoa u c c hay tng cp, trn cng di, hoa
hnh mi vng, ci, 5-10, gia hoa c l hoa l vy. B qu khng c lng mo, cao
4mm (hnh 1.1b).
L li tiu, hoa x mnh.
Cy mc n , Nam Trung Quc, Vit Nam, Thi Lan, Malaixia,
Innxia, Philippin, nc ta cy sn cc hai hoa c trng lm cnh trong cc
cng vin thnh ph H Ch Minh, Lt
1.1.2. Sn cc nhm - Wedelia urticaefolia (Bl.) DC. (Hnh 1.2)
Sn cc nhm c tn khoa hc l Wedelia urticaefolia (Bl.) DC. [1, 5].
Sn cc nhm l dng cy c a nin ng. Thn c lng nm, nhm. L c
phin xoan nhn, di 6-12cm. Hoa u khng hay c cng, c vy, hoa hnh ba mi
vng, ci; hoa gia hnh ng, lng phi. B qu dp, cao 1mm, khng lng mo.
Phn b n , Trung Quc, Vit Nam, Lo, Thi Lan, Innxia. nc
ta, cy mc hoang rt nhiu hu ht cc tnh t Lo Cai, Cao Bng n Ninh
Thun, Lm ng
HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

1.1.3. Sn cc b - Wedelia chinensis (Osb.) Merr. (Hnh 1.3)

Sn cc b c tn khoa hc l Wedelia chinensis (Osb.) Merr. [1].
Sn cc b cn c gi l sn cc Trung Quc.
Dng cy c a nin b t, thn c lng phn. L c phin hp di 5-8
cm, rng 1 cm, c lng nhm, ba c rng nhn, tha. Hoa u c c trn cng di
cht nhnh, rng 1,5 cm, hnh mi vng, hoa trong hnh ng, lng phi. B qu
c a mng, c rng th lng mo.
Thng phn b i ct k bin Vng Tu, Hu, Qui Nhn,
1.1.4. Sn cc ba thy - Wedelia trilobata (L.) Hitch. (Hnh 1.4)
Sn cc ba thy c tn khoa hc l Wedelia trilobata (L.) Hitch.
Sn cc ba thy cn c tn l cc b.
Cy sn cc ba thy l loi tho mc sng lu nm, c th mc thng cao
n 45 cm, hoc b lan n 1,8 m. Cy thng mc thnh tng mng, dy c che
kn mt t. Thn b, r mc ti cc t, di khong 1-3 dm. L dy, di khong 4-9
cm, rng 2-5 cm c rng ca hai bn thy l, c lng cng v th c hai mt.
Hoa mu vng ti, nhiu cnh thnh tng, cung hoa di 3-10 cm, tng bao c
dng chung, u hoa thng c khong 8-13 hoa tia, a trng hoa di 4-5 mm, b
qu c nt sn.
Cy c tm thy nhiu Trung M, Ty Phi, Hawai, Nam Florida,
Vit Nam, cy mc hoang nhiu ni v c dng rng ri lm cy king.
1.1.5. Wedelia paludosa DC. (Hnh 1.5)
Cha thy c ti liu no cp n.
1.1.6. Si t - Wedelia calendulacea (L.) Less (Hnh 1.6)
Si t c tn khoa hc l Wedelia calendulacea (L.) Less. [6].
Si t cn c gi l hng trm, ng ni, cc nhp, cc gip, bnh k cc.
Si t l mt loi c sng dai, mc lan b, ch thn mc ti u, r lan ti
, ni t tt c th cao 0,5m. Thn mu xanh, c lng trng, cng, nh. L gn
nh khng cung, mc i, hnh bu dc thon di, hai u nhn, di 15-50 mm,
rng 25 mm, c lng nh cng hai mt, mp c 1-3 rng ca nng. Cm hoa hnh

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

u, cung hoa di, vt qua cc nhnh l, cnh hoa mu vng ti. Qu b khng
c lng, u thu hp li, tn cng mang mt vng c rng.
Thng mc hoang nhiu tnh min bc, nhng ni m mt.
1.1.7. L a cc - Wedelia prostrata (H. & A.) Hemls (Hnh 1.7)
L a cc c tn khoa hc l Wedelia prostrata (H. & A.) Hemls. [6].
L a cc cn c tn gi l bnh k cc.
Cy dng c a nin, b t, thn c lng phn. L c lng nhm tha,
phin di 1-2 cm, ba c t rng. Hoa u c c, hnh mi vng, c vy gia cc
hoa, hoa hnh ng, lng phi. B qu cao 1 mm, u c lng mn, khng lng mo.
Thng c dng lm thuc mc tc, tr nhc u.
Phn b n , Trung Quc, Vit Nam, Lo, Thi Lan, Innxia. nc
ta, cy mc hoang nhiu ni. Thng phn b vng i ct da bin Hu, Qui
Nhn, Nha Trang, Vng Tu.

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

Hnh 1.1a: Ton cy Sn cc hai hoa - Wedelia biflora (L.) DC.

Hnh 1.1b: L, hoa, ht ca Wedelia biflora (L.) DC

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

Hnh 1.2: Wedelia urticaefolia (Bl) DC.

Hnh 1.3: Wedelia chinensis (Osb.) Merr.

Hnh 1.4: Wedelia trilobata (L.) Hitch

Hnh 1.5: Wedelia paludosa DC.

Hnh 1.6: Wedelia calendulacea (L.) Less

HV: Nguyn Th Hoi Thu

Hnh 1.7: Wedelia prostrata (H. & A.) Hemls

Wedelia biflora (L.) DC

Tng quan

1.2. THNH PHN HA HC

1.2.1. Cy sn cc hai hoa - Wedelia biflora (L.) DC.
Nm 1993, Miles D. Howard

[20]

c lp t cao diclorometan ca l kh

Wedelia biflora c bn hp cht: veratrylidenehydrazid (59); 3,3'-di-Ometylquercetin (47); 2,7,4-trihydroxy-5,3-dimetoxyisoflavon (51) v 7,3-di-Ometyl quercetin (48).
Nm 2005, Nguyn Thanh Hong v cng s

[3]

c lp t l cy Wedelia

biflora c hai hp cht l: -amyrin acetat (36) v acid kaur-16-en-19-oic (28) v

c lp t hoa cy Wedelia biflora c hai hp cht l: 3-hexanoyloxyolean-12en-28-ol (38) v acid 3-hexanoyloxyolean-12-en-28-oic (39).
1.2.2. Cy sn cc nhm - Wedelia urticaefolia (Bl.) DC.
Nm 2007, Nguyn Thanh Hong v cng s

[2, 23]

c lp c -amyrin

(35); 3-acetoxy--amyrin (36), 3-O-tetradecanoylurs-12-en-16-ol (37); phytol

(15) v acid kaur-16-en-19-oic (28) t hoa ca cy Wedelia urticaefolia.
1.2.3. Cy sn cc b - Wedelia chinensis (Osb.) Merr.
Nm 1986, Yang Ling Ling

[34]

c lp t Wedelia chinensis c acid

kaur-16-en-19-oic (28) v stigmasterol glucosid (46).

Nm 2002, Apers Sandra v cng s [8] c lp t cy thuc Wedelia chinensis
Trung Quc c acid 3,4-dicaffeoylquinic (57); acid 3,5-dicaffeoylquinic (56); acid
4,5-dicaffeoylquinic

,3,4-trihydroxyphenyletyl-O-[-apiofuranosyl-(14)--

rhamnopyranosyl-(13)]-(4-O-caffeoyl)--glucopyranosid hay wedelosin (58); cng

lc vi ba flavonoid glycosid l: 3-O--glucopyranosylquercetin (54); 3-O-apiofuranosyl-(1-2)--glucopyranosylkaempferol (53) v astragalin hay 3-O-glucopyranosylkaempferol (52).
1.2.4. Cy sn cc ba thy - Wedelia trilobata (L.) Hitch.
Nm 2000, Koheil M. A. v cng s [19] kho st thnh phn tinh du ca hoa
Wedelia trilobata bng GC-MS. Kt qu cho thy thnh phn ca tinh du gm 48
cht trong thnh phn chnh l -phellandren (25,65%); limonen (8,93%); terpinen (5,90%); trans--caryophyllen (4,83%) v -pinen (4,72%).

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

Nm 2004, Zhang Yuhu

[35]

c lp c 6 sesquiterpen t cy Wedelia

trilobata: trilobolid-6-O-isobutyrat hay wedeliatrilolactone A (8); 1-acetoxy4,9-dihydroxy-6-isobutyroxyprostatolid (10); hn hp gm hai hp cht l

1,9-diacetyloxy-4-hydroxy-6-isobutyryloxyprostatolid hay wedeliatrilolactone
B (9) v 1,9-diacetyloxy-4-hydroxy-6-metacryloxyprostatolid (12); 1,4dihydroxy-6-isobutyryloxy-9-tigloyloxyprostatolid (13) v 9-angeloyloxy1,4-dihydroxy-6- isobutyryloxyprostatolid (14).
Nm 2005, Nirmal v cng s

[25]

kho st thnh phn ha hc tinh du

ca l Wedelia trilobata bng GC-MS. Kt qu cho thy tinh du cha 14 hp cht,

trong -pinen; germacren D v d-limonen chim n 85,52%.
Nm 2006, Nguyn Thanh Hong v cng s [24] c lp t l ca Wedelia
trilobata c friedelan-3-ol (34); -amyrin acetat (36) v acid 3-tigloyloxykaur16-en-19-oic (25).
1.2.5. Wedelia paludosa DC.
Nm 1987, Roque Nidia F. [28] c lp t r Wedelia paludosa c: metyl 9hydroxykaur-16-en-19-oat (21); metyl kaur-16-en-19-oat (22); metyl 3-angeloyloxy9-hydroxykaur-16-en-19-oat (18); metyl 3-angeloyloxykaur-16-en-19-oat (19); metyl
3-tigloyloxykaur-16-en-19-oat (20); metyl 3-cinamoyloxykaur-16-en-19-oat (23);
metyl 3-cinamoyloxy-9-hydroxykaur-16-en-19-oat (24); mt labdan l (1R,2R,8aS,Z)2,5,5,8a-tetrametyl-1-(3-metylpenta-2,4-dienyl)-decahydronaptalen-2-ol
secokauren

lacton

(15);

mt

(1R,5S,8R)-1,5-dimetyl-8-{2-[(1S,5R)-6-metylen-2-

oxobicyclo[3.2.1]oct-1-yl]etyl}-6-oxabicyclo[3.2.1]octan-7-on (17).
Nm 2001, De Carvalho v cng s [12] c lp t hoa Wedelia paludosa c
acid kaur-16-en-19-oic (28); acid kaur-9(11),16-dien-19-oic (27); acid 3-Ohexadecanoylolean-12-en-28-oic (40); acid 3-O-pentadecanoylolean-12-en-28-oic
(41); acid 3-O-tetradecanoylolean-12-en-28-oic (42); stigmasterol (45); hn hp
3-O--D-glycopyranosylsitosterol v 3-O--D-glucopyranosylstigmasterol (46).
Nm 2003, Sartori M. R. K. v cng s

[29]

c lp t hoa Wedelia

paludosa c hai hp cht l acid kaur-16-en-19-oic (28) v luteolin (49).

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

Nm 2004, Cechinel Filho Valdir v cng s

[11]

c lp t cy Wedelia

paludosa c stigmasterol (45), acid kaur-16-en-19-oic (28) v acid oleanolic v

eudesmanolid (4).
1.2.6. Si t - Wedelia calendulacea L.
Nm 1991, Govindachari T. R.

[16]

c lp t l cy ti Wedelia

calendulacea c -D-glucopyranosyl 3-[(O--D-xylopyranosyl)-(12)-(-Dglucuronopyranosyl)]olean-12-en-28-oat (43) v -D-glucopyranosyl 3-[(O--Dglucopyranosyl)-(12)-(-D-glucuronopyranosyl)]olean-12-en-28-oat

hay

ginsenosid Ro (44).
Nm 1998, Nguyn Ngc Sng v cng s

[22]

c lp t l ti cy

Wedelia calendulacea c mt sesquiterpen lacton l wedelolacton (6) v acid 5,6dihydroxy-2-(2',4',6'-trihydroxyphenyl)benzofuran-3-carboxylic

hay

acid

norwedelic (7).
Nm 2003, Mottakin A. K. M.

[21]

v cng s c lp t Wedelia

calendulacea c ba diterpen l: acid 3-tigloyloxykaur-16-en-19-oic (25); acid

3-angeloyloxykaur-16-en-19-oic (26) v acid kaur-16-en-19-oic (28).
1.2.7. L a cc - Wedelia prostrata (H. & A.) Hemls
Nm 1993, Ragasa Consolacion Y. v cng s
prostrata

thu

hi

Philippines

[27]

c lp t cy Wedelia

1-acetoxy-4,9-dihydroxy-6-

metacryloxyprostatolid (11) v acid 3-cinamoyloxykaur-16-en-19-oic (32).

Nm 2001, Farag Salwa F.

[13]

c lp t dch chit cloroform ca phn trn

mt t ca cy Wedelia prostrata c 3-hydroxycarvotagenon (1); 3hydroxycarvotagenon (2); p-ment-1-en-3,6-diol (3); acid 16,17-dihydroxykauran-19oic (30) v 3-O--D-glucopyranosylkaempferol (52). Hn th na, tc gi cng c lp
c t r ca cy ny c stigmasterol (45); acid 15,16-epoxy-17-hydroxykauran19-oic (31); stigmasterol 3-O--D-glucopyranosid (46); quercetin-3-O--D-rutinosid
(55); acid 3,5-dicaffeoylquinic (56) v acid 3,4-dicaffeoylquinic (57).

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

Cu trc ha hc ca cc cht c lp c t cc loi thuc chi Wedelia c

trnh by theo cc loi hp cht nh sau:
Monoterpen
OH

OH

OH

3-Hydroxycarvotagenon
(1)

OH

3-Hydroxycarvotagenon
(2)

p-Ment-1-en-3,6-diol
(3)

Sesquiterpen
HO
HO

OH
HO

OH

HO

CHO O

AcO

OAc
H

HO

OH

HO

HO

OH

2
3

OH
COOH

Acid norwedelic
(7)

OH

HO

AcO

HO

Wedelolacton
(6)

HO
1

AcO

OAc
H

HO

2-[4-Metyl-3-(prop-1-en-2-yl)
-4-vinylcyclohexyl]propan-2-ol
(5)

Eudesmanolid
(4)

AcO

OCH3

H
O

Wedeliatrilolacton A Wedeliatrilolacton B 1-Acetoxy-4,9-dihydroxy 1-Acetoxy-4-dihydroxy

-6-isobutyroxyprostatolid
-6-metacryloxyprostatolid
(8)
(9)
(10)
(11)
O
AcO
1

9
4

HO

HO

OAc
H

9
4

HO

HO

9
4

HO

H
O

1,9-Diacetoxy-4-hydroxy 1,4-Dihydroxy-6-isobutyryloxy 9-Angeloyloxy-1,4-dihydroxy

-6-metacryloxyprostatolid
-9-tigloyloxyprostatolid
-6- isobutyryloxyprostatolid.
(12)
(13)
(14)

Diterpen
HO

Phytol
(15, Hoa Wedelia urticaefolia)

HV: Nguyn Th Hoi Thu

Wedelia biflora (L.) DC

Tng quan

6'

5'
1

16

16

16
9

OH

H3CO

19

H3 CO

19

H3CO

19

Metyl 9-hydroxykaur
-16-en-19-oat
(21)

Metyl 3-tigloyloxy
kaur-16-en-19-oat
(20)

16

16

16
9

O
3

H3CO

19

OH

H3CO

19

H
19

Metyl kaur-16-en-19-oat
(22)

H
19

Metyl 3-angeloyloxy- 9-hydroxy Metyl 3-angeloyloxy

kaur-16-en-19-oat
kaur-16-en-19-oat
(18)
(19)

H3CO

H3CO

16

OH
O

(1R,5S,8R)-1,5-Dimetyl-8-{2-[(1S,5R)-6-metylen
-2-oxobicyclo[3.2.1]oct-1-yl]etyl}
-6-oxabicyclo[3.2.1]octan-7-on
(17)

(1R,2R,8aS,Z)-2,5,5,8a-Tetrametyl-1-(3-metylpenta
-2,4-dienyl)-decahydronaptalen-2-ol
(16)

2'

8a

HO

1'

Metyl 3-cinamoyloxykaur-16-en-19-oat
(23)

Metyl 3-cinamoyloxy
-9-hydroxykaur-16-en-19-oat
(24)

O
O

HOOC

HOOC

HOOC

Acid 3-tigloyloxykaur-16-en-19-oic Acid 3-angeloyloxykaur-16-en-19-oic Acid kaura-9(11),16-dien-19-oic

(27, Hoa Wedelia paludosa)
(25)
(26)

OH

OH
OH

HOOC

HOOC

Acid kaur-16-en-19-oic
(28, Hoa Wedelia paludosa,
Hoa Wedelia urticaefolia)

HOOC

Acid 16-hydroxykauran-19-oic Acid 16,17-dihydroxykauran-19-oic

(29)

(30)

OH
O

HOOC

Acid 15,16-epoxy
-17-hydroxykauran-19-oic
(31)

HOOC

O
H

Acid 10-hydroxy-9-metyl
Acid 3-cinamoyloxykaur-16-en-19-oic -20-norkaur-16-en-19-oic--lacton
(32)
(33)

HV: Nguyn Th Hoi Thu

10

Wedelia biflora (L.) DC

Tng quan

Triterpen
12
9
3

12

13

H3C C O

HO

HO

-Amyrin

Friedelan-3-ol
(34)

-Acetoxy--amyrin
(36, Hoa Wedelia urticaefolia))

(35, Hoa Wedelia urticaefolia)

12

12

CH 2OH

16

COOH

28

OH
3

H3C(CH2)12

H3C(CH2)4

C O
O

-Tetradecanoyloxyurs-12-en-16-ol
(37, Hoa Wedelia urticaefolia)

C O

H3C(CH2)4

-Hexanoyloxyolean-12-en-28-ol
(38, Hoa Wedelia biflora)

C O
O

Acid -hexanoyloxyolean-12-en-28-oic

(39, Hoa Wedelia biflora)

COOH
COOH

COOH
H3C(CH2)13
H3C(CH2)14

C O

C O

H3C(CH2)12

Acid 3-(hexadecanoyloxy)olean
-12-en-28-oic
(40, Hoa Wedelia paludosa)

COOH
2

HO
HO

O
O

Acid 3-(tetradecanoyloxy)olean
-12-en-28-oic
(42, Hoa Wedelia paludosa)

Acid 3-(pentadecanoyloxy)olean
-12-en-28-oic
(41, Hoa Wedelia paludosa)

HO
HO

C O

COOH
O

OH
HO
HO

O
OH

OH

HO
HO
OH

O
HO
HO

O
O

OH
HO
HO

OH

OH

-D-Glucopyranosyl 3-[(O--D-xylopyranosyl)
-D-glucopyranosyl 3-[(O--D-glucopyranosyl)
-(1 2)-(-D-glucuronopyranosyl)]olean-12-en-28-oat -(1 2)-(-D-glucuronopyranosyl)]olean-12-en-28-oat
(43)
(Ginsenosid Ro), (44)

HV: Nguyn Th Hoi Thu

11

Wedelia biflora (L.) DC

Tng quan

Sterol

OH
O

HO
HO

HO

O
OH

Stigmasterol
(45, Hoa Wedelia paludosa)

Stigmasterol 3-O-D-glucopyranosid
(46, Hoa Wedelia paludosa)

Flavon
OCH3
3'

OH

OCH3
3'

OH

OH
3'

OH

OH

OH
4'

HO

H 3CO

HO

HO

OCH 3
OH

OH
OH

OH

Luteolin
7,3'-Di-O-metylquercetin
7,3',4'-Trihydroxyflavanon
(49, Hoa Wedelia paludosa)
(48)
(50)

3,3'-Di-O-metylquercetin
(47)

O
H
O

HO

OH

HO
OH

HO

OH

OCH3 O

OH

2,7,4'-Trihydroxy
-5,3'-dimetoxyisoflavon

HO

HO
HO

OH

HO
HO

HO
OCH3

HO

OH

OH

3-O--D-Glucopyranosylkaempferol

(51)

(52)

-(1

OH

3-O--D-Apiofuranosyl
2)--D-glucopyranosylkaempferol
(53)

OH
OH

OH
OH
HO

HO

O
3

OH

O
OH
HO
HO

OH

HO
HO

HO

O
OH

HO
OH

3-O--D-Glucopyranosylquercetin
(54)

HV: Nguyn Th Hoi Thu

OH

Quercetin 3-rutinosid
(55)

12

Wedelia biflora (L.) DC

Tng quan

Dn xut ca acid caffeic

OH

OH
O
O
O
5

HO

OH OH3

OH
OH O 3

O
OH

HOOC

OH

O
1

HO

OH

OH

OH
O

O
OH

OH
HO

O
HO

OH

Acid 3,4-dicaffeoylquinic
(57)

O
2

HOOC

OH

HO

OH

Acid 3,5-dicaffeoylquinic
(56)

HO

OH

Wedelosin
(58)

OH

Hydrazid
OCH3

O
N
N

OCH3

H3CO
OCH3

Veratrylidenhydrazid
(59)

1.3. DC TNH HC
1.3.1. Cy sn cc hai hoa - Wedelia biflora (L.) DC.
C Mau v nhiu ni khc [1], ngi dn dng t l non lm rau xo vi
tht, c len, c, ra. L cy c dng lm thuc tr ni m ay bng cch ly ba
nm l gi, vt ly nc ri pha vi ng hoc mui ung.
n [1], l c gi ra, dng lm thuc p ln vng da b bin mu, p
ln vt ct, vt su b t, lot, sng, gin tnh mch. L cn c dng p vo
bng ph n sau khi sinh, sc ly nc ung tr i tiu ra mu. R dng tr bnh lu,
si thn hoc dng p ln vt thng, gh nga.
Thi Lan [1], ngi ta dng thn, l tr au u v st.
HV: Nguyn Th Hoi Thu

13

Wedelia biflora (L.) DC

Tng quan

1.3.2. Sn cc nhm - Wedelia urticaefolia (Bl.) DC.

Vn Nam (Trung Quc)

[1]

, ngi ta s dng Wedelia urticaefolia lm

thuc thanh nhit, gii c, b huyt v hot huyt tr vim phi v nhng tn
thng do t ng.
1.3.3. Sn cc b - Wedelia chinensis (Osb.) Merr.
Wedelia chinensis [4] c dng lm thuc h nhit, khng sinh, tr nhc u,
tr bnh gan, tr ph bng, chng vim, tr ra mu t cung, tr bnh da, t thp.
Trung Quc, c ni dng Wedelia chinensis tr ung th (Ehrlich ascite).
Nm 1986, Yang Ling Ling

[34]

c lp t Wedelia chinensis c acid

kaur-16-en-19-oic v stigmasterol glucosid v chng minh rng hai hp cht ny

c tc dng lm gim c tnh ca t bo gan chut b gy c bi CCl4 hoc Dgalactosamin.
Nm 2005, Bai Xiang Yang [10] lm ra sn phm tr Wedelia chinensis bng
cch phi trn phn thn v cung Wedelia chinensis vi cc dc phm b sung
theo t l khi lng l 1:0,3. Tr c tc dng thanh nhit, gii c, kch thch tiu
ha, tt cho bao t, l lch, gip hi phc ci thin sc khe.
1.3.4. Sn cc ba thy - Wedelia trilobata (L.) Hitch.
Nm 2004, Zhang Yuhu

[35]

chng minh rng 6 sesquiterpen c lp t cy

Wedelia trilobata c hot tnh c ch s pht trin mm ca cy c ci, ci bp, c

chua
Nm 2005, Baczynski v cng s

[9]

cho bit b tc Miskito ca n s

dng Wedelia trilobata tr rn cn, vt thng do c ui gai c gy ra. Ngoi

ra, cy cn cha c cc bnh nh: tiu chy, si thn, cm lnh
Nm 2005, Nirmal v cng s

[25]

cho bit tinh du ca l Wedelia trilobata

c hot tnh khng khun ng k vi chng vi khun Bacillus subtilis v

Staphylococcus aureus.
1.3.5. Wedelia paludosa DC.
Nm 2003, theo Sartori M. R. K. v cng s

[29]

, ngi dn Brazin s dng

Wedelia paludosa nh cy thuc truyn thng dng tr bnh nm ngoi da. Dch
trch hexan, diclorometan and butanol ca hoa Wedelia paludosa th hin hot tnh
HV: Nguyn Th Hoi Thu

14

Wedelia biflora (L.) DC

Tng quan

khng li cc chng nm gy bnh ngoi da nh: Epidermophyton floccosum,

Trichophyton rubrum v Trichophyton mentagrophyte, vi nng t 250 n 1000
g/ml. Hai hp cht tinh khit l acid kaurenoic v luteolin cng cho thy c hot
tnh khng nm ny.
1.3.6. Si t - Wedelia calendulacea (L.) Less.
Trn lm sng, cy si t biu hin hai tc dng r rt

[6]

: gim au, gim

st, khng sinh r rt, khng thy c tnh. Nhn dn H Bc v nhiu ni khc
dng cy Si t n sng nh rau vi tht c. Mt s ni dng Si t tr rm sy
hoc ung phng si, cha st rt, vim ty ngoi da, khp xng, nhim trng, l
lot, mn nht, au mt, vim bng quang
Nm 2004, Mottakin A. K. M. v cng s [21] th nghim hot tnh khng
19 chng vi khun v th nghim c tnh Brine Shrimp ca cc dch chit nh: eter
du ha, cloroform, metanol v ca ba diterpen c lp c t cy Wedelia
calendulacea. Kt qu th nghim c tnh Brine Shrimp cho thy cc dch chit c
hot tnh tt vi liu LC50 l 4,59 g/ml (dch chit eter du ha), 7,99 g/ml (dch
chit cloroform), 14,88 g/ml (dch chit metanol). Ring hp cht acid (-)-kaur16-en-19-oic cho thy c hot tnh khng khun vi hu ht cc chng vi khun th
nghim, vi liu 200 g/ a th ng knh vng v khun l 10-21 mm.
1.3.7. L a cc - Wedelia prostrata (H. & A.) Hemls
Nhn dn Trung Quc [6] dng cy L a cc ti tr vim amyan cp tnh,
sng au c hng, vim phi, vim ph qun, ho lu ngy, cao huyt p, ho ra mu,
chy mu cam, u mi. Dng cy L a cc ti cng vi dm cha bnh bch
hu c kt qu 96,75%. L a cc phi kh, nu cao dng tiu c, cha vim ty,
nht, p-xe, ho, l lot

HV: Nguyn Th Hoi Thu

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