HORMON

V CC CHT LIN QUAN

Phan Th Nh Qunh, MSc.
B mn Ha Dc
Khoa Dc, HYD Hu

I CNG

HORMON
nh ngha:
Hormon l nhng cht c tit ra bi cc t bo
c hiu v tc dng ln cc receptor c hiu

c im:
Tc dng vi liu lng rt thp
Tc dng c hiu
Cc tuyn lin h vi nhau thnh h thng ni
tit
Lin h cht ch vi h thng TK

HORMON
Bn cht ha hc:
Cu trc steroid:
Hormon v thng thn, hormon sinh d c
Cha nhn cyclopentanoperhydrophenanthren

Cu trc acid amin:

Hormon tuyn gip, hormon ty th ng th n

Cu trc peptid, polypeptid

Hormon tuyn yn

HORMON
C ch tc ng:
nh hng n hot ng gene v s tng h p
protein:
Hormon tan/lipid
Phc hp hormon-receptor gn vo ADN

Tc dng thng qua cc repetor ph thu c G-protein

Hormon cu trc peptid
Lm thay i lng cAMP

Hot ng thng qua protein kinase

Hormon polypeptid
iu ha s tng trng, bit ha

HORMON
iu ha bi tit hormon:
Vng di i l trung tm iu ha ca h
thng ni tit:
Yu t gii phng (RF: releasing fator)
Yu t c ch (IF: inhibiting factor)

Tuyn yn:
Sn xut hormon chi phi hot ng ca cc tuyn
khc
Chu s kim sot ca vng di i

HORMON
Cc loi hormon

Hormon vng di i
Hormon tuyn yn
Hormon tuyn gip
Hormon tuyn ty
Hormon v thng thn
Hormon sinh dc

HORMON VNG DI I

Hormon

Tn y

Chc nng

p dng tr liu

GHRH

Growth Hormon
Releasing
Hormon

Gy phng thch GH

Chn on nguyn nhn thiu

GH
Lm tng chiu cao TE thiu
GH

Somatostatin
(SRIH)

Somatotropin
Realease
Inhibiting
Hormon

c ch phng thch GH,

TSH, glucagon, insulin v
gastrin, c ch bi tit
d dy-rut

Chng to cc
U ty, u t trng, u t bo tit
glucagon

TRH

Thyrotropin
Releasing
Hormon

Kch thch bi tit TSH v Chn on bnh tuyn gip

prolactin

CRH

Corticotropin
Releasing
Hormon

Kch thch bi tit ACTH

v beta-endorphin

Chn on kh nng tit

ACTH ca tuyn yn

GnRH

Gonadotropin
Releasing
Hormon

Kch thch/c ch tit

gonadotropin

Thiu gonadotrpin gy gim

chc nng tuyn sinh dc
Dy th sm, ung th tuyn
tin lit, ung th v ph
thuc estrogen

Dopamin
(PIH)

Prolactin
Inhibiting
Hormon

c ch tit prolactin

Kim sot tng prolactin

huyt

HORMON TUYN YN

Hormon tuyn yn
Hormon tin yn

Hormon hu yn

GH (somatotropin)
TSH (Thyroid-Stimulating
Hormon)
ACTH (Adrenocorticotropin)
Gonadotropin
Prolactin

Oxytoxcin
Vasopressin (Antidiuretic
Hormon, ADH)

GH
L peptid gm 191 acid amin
c bi tit nh GHRH v c ch bi tit bi
somatostatin
C ch tc dng:
Trc tip: hormon gn vo receptor t bo ch
Gin tip: kch thch sn xut IGF gan v cc
m khc. IGF lm tng sinh sn, xng, m mm,
tng s lng t bo

GH
Tc dng:
Kch thch tng trng c th tr em
iu ha chuyn ha t bo ngi ln v tr em

p dng tr liu:
Tr thiu GH cho tr em
Somatrem v Somatotropin ti t hp ADN

TSH
C ch tc dng:
Kch thch adenyl cyclase t bo tuyn gip
tng bt gi iod v sn xut hormon gip

p dng:
Chn on phn bit gim nng tuyn gip
nguyn pht v th pht
Dng BN ung th tuyn gip di cn

ACTH
Thnh lp t proopiomelanocortin
c tit vo ban ngy, cao nht lc sng sm
p dng:
Lm tng bi tit hormon v thng thn
Chn on sn xut corticosteroid bt thng

Gonadotropin
L tn chung ca 3 hormon tc dng trn t bo
sinh dc:
LH (luteinizing hormon): hormon to hong th
FSH (follicle stimulating hormon): hormon kch
thch to nang trng
hCG (human chorionic gonadotropin):
gonadotropin nhau thai

Gonadotropin
Tc dng:
Sinh bo t v sn xut steroid sinh dc
FSH:
Pht trin nang trng
Kch thch sinh tinh trng

LH:
Tng hp progesteron th vng v tng hp
androgen bung trng
Kch thch tng hp testosteron

Gonadotropin
p dng:

Tr v sinh cho ph n v nam gii

Trnh thai
Tr tinh hon n trc dy th
Chn on c thai
Chn on ngy rng trng
Chn on cc bnh ca h sinh dc nam v n

Prolactin
C ch ngn tit l ch yu: cht ch vn c
ch tit, cht i khng tng tit prolactin
Khng kch thch tng hp v bi tit m ch
nn khng c c ch feed back
Tc dng:
Cng cc hormon khc kch thch tuyn v pht
trin trong thi gian mang thai v duy tr s sinh
s n
Tng prolactin huyt: c ch trc d i i-tuy n
yn-sinh dc gy bt lc, chy sa, v kinh, v
sinh

Oxytoxin
c tng hp vng di i, tch tr thy
sau tuyn yn
Tc dng:
Kch thch co tht t cung tng chuyn d, gy
sy thai trong iu tr
Gy co tht c trn tuyn v kch thch tit sa

Vasopressin
c tng hp vng di i v bi tit
thy sau tuyn yn
Tc dng:
Trn receptor V1: gy co c trn
Trn recepor V2: tng tnh thm t bo ng thn
tng ti hp thu nc li tiu

Tm tt cht tng t hormon vng di i v tuyn yn c s dng trong tr liu

Thuc

Tc ng

Ch nh

Ch thch

Somatrem

GH

Suy tuyn yn

GH cha methionin N tn
cng, ti t hp ADN

Octreotid

Tng t
somatostatin

Chng bi tit
nhiu tuyn

Tc dng di hn
somatostatin thin nhin

Cosyntropin

Tng t ACTH,
Thay th
kch thch v thng corticosteroid
thn
trong chn on

Cha 24 aa u c hot tnh

ca ACTH

Leuprolid,
goserelin,
nafarelin

Tng t GnRH

V sinh, ung th

Kch thch tuyn sinh dc

nu dng theo nhp sinh l,
c ch nu dng lin tc

V sinh

Ly trch t nc tiu ngi

Urofollitropin Ging FSH

hCG

Ging LH

V sinh

Ly trch t nc tiu ngi

Menotropin

Hot tnh FSH & LH V sinh

Ly trch t nc tiu ngi

Bromocriptin

c ch phng thch
prolactin

Ngn tit sa, c

ch u tuyn yn

Alcaloid ergot, cht ch vn

dopamin mnh

i tho nht do
tuyn yn

Ch vn receptor V2, tc
dng di hn ADH

Desmopressin Tng t ADH

THANK YOU!