INHIBISI ENZIM

WARDATUL BAEDHO
MELIA DWI RAHMAWATI

(101810301045)
(101810301052)

Inhibitor
Irreversibel

Enzim Kimotripsin

Diisopropilfluorofosfat
(DIFP) menginhibisi enzim
kimotripsin

Inhibitor
Kompetitif

Persamaan & Grafik Michaelis

Menten

Contoh inhibitor kompetitif: malonat menginhibisi enzim sussinat

dehidrogenasi

Inhibitor
Unkompetitif

Persamaan & Grafik Michaelis

Menten

Alkaline
phosphatase

Alkaline
phosphatase

O
O P
O-

-O

O
P
O-

O
O P
O-

Alkaline
phosphatase

Alakaline
Phosphatase

Phe

Contoh inhibitor unkompetitif: fenilalanin menginhibisi enzim alkalin

fosfatase

Inhibitor
Nonkompetitif

Persamaan & Grafik Michaelis

Menten

O
O P OO
H2 C

O
O P OO
CH2

fructose 1,6diphosphate

fructose 6phosphate

HO

OH
OH

Pi

fructose 1,6diphosphate

fructose 1,6bisphosphatase

fructose 1,6bisphosphatase

E.S

E
AMP

AMP

AMP
O
O P Ofructose 1,6O
diphosphate H C
2

O
O P OO
CH2

HO

fructose 1,6diphosphate

E.I

E+P
AMP

AMP

AMP

fructose 1,6bisphosphatase

fructose 1,6bisphosphatase

OH
OH

fructose 1,6bisphosphatase

E.S.I

Contoh inhibitor nonkompetitif: AMP menginhibisi enzim fruktosa 1,6bisfosfatase