CROUZON SYNDROME

Intoduction
Crouzon syndrome is an autosomal dominant skeletal dysplasia characterized
by variable expressivity and almost complete penetrance. (white nd Pharoah 6th
edi)It is a rare first brachial arch syndrome affecting about one in 60,000
individuals.(Oral diseases2009 15,367-368). Fibroblast growth factor receptor gene
mutation on chromosome 10( locus q 26 )might be the reason for the onset of
syndrome.[Medscape]
Disease is characterized by premature closure of cranial sutures. (premature cranio
synostosis).