NAME

PHARMACOKINETIC

TCA

EXAMPLES
Amitriptyline
(M1 receptor antagonist)
Imipramine

Blocks NA and 5-HT reuptake

Delayed therapeutic effect
Greater affinity with post synaptic receptors

Lofepramine
Trazodone

Fluoxetine
-

SSRI

Low affinity of post synaptic receptors.

Lag time before therapeutic effect onset.

Sertraline
-

SNRI

Low affinity of post synaptic receptors.

NARI
MAOI

Atypical

Low affinity of post synaptic receptors.

Increase store of NA and 5-HT.
Blocks the action of MAO (transmitter
metaboliser).
Decrease intra-neuronal b/down
Increase vesicles content of monoamines
Increase release of monoamines.
Old: irreversible, non-selective
New: reversible, selective to MAOA
Treatment of schizophrenia.
Used in combination with lithium or valproate.

Prescribed for newly diagnosed,

mild depression

Venlafaxine
Reboxetine
Old: Phenelzine, Tranylcypromine

New: Moclobemide
Mirtazepine, Nefazodone
Olanzapine, Risperidone,

GENERAL S/E
Dry mouth (Ami)
Blurred vision (Ami)
Constipation (Ami)
Urinary retention (Ami)
Sedation (more than SSRI)
Weight gain
Postural hypertension
Cardiotoxic
o Anxiety
o Nausea
o Constipation
o Impotence
o Weight gain
o Drug interactions
o Inhibited cytochrome P450
o Sedation/anticholinergic s/e
o Increased bleeding in elderly: must use with
caution with patients of bleeding d/order.
Less side effect
Less side effect
Hypertensive reaction in presence of tyramine &
dopamine.
Drug interaction with SSRI: hyperthermia,
confusion & hypertensive crisis.
MAOI (2wks)Fluoxetine (5 wks)-MAOI
Narrow therapeutic window and long duration of
action.

Quetiapine, Aripiprazole
Mianserin
-

Interfere with inositol triphosphate formation.

Monoamine receptor antagonist

Acute toxic effects.

Thyroid disorders and mild cognitive impairment

CPTP 3.3 ANTI-CANCER DRUGS

DRUGS
Alkylating agents
TAMOXIFEN
CYTOTOXIC

PHARMACOKINETICS
Induces DNA double helix to break.
Inhibit DNA replication.
Contains
bischloroethlyamine
Crosslinking the DNA strand.

EXAMPLE

group.

Cyclophophamide

SIDE EFFECT