FDA Pregnancy Risk Category

Category A

(

 
(

Category B
  (


(
Category C


(
(

Category D
 (

(

(
 
Category X

(

(

 
 

( 

(
Alprostadil
Prostin VR
Atrovastatin
Lipitor
Bicalutamide
Casodex
Conjugated estrogens Premarin
Danazol
Ladogal
Ergotamine + Caffeine Cafergot
Estradiol valerate +
Cyclo-Progynova
Norgestrel
Ethinyl estradiol +
Microgest
Levonorgestrel (Oral
contraceptive)
Finasteride
Firide, Proscar
Fluorouracil (5-FU)
Isotretinoin
Leflunomide
Avara
Letrozole
Femera
Leuprorelin
Enantone
Medroxyprogesterone Farlutal, Manodepo
Methotrexate (MTX)
Methylene blue
Misoprostol
Cytotec
Norethisterone
Primolut-N
Oxymetholone
Androlic
Ribavirin
Rebetol
Rosuvastatin
Crestor
Simvastatin
Vitamin A
Warfarin
Orfarin

Route of Administration Pregnancy risk category

Parenteral
X
PO
X
PO
X
PO, Vaginal cream
X
PO
X
PO
X
PO
X
PO

PO
PO, Parenteral
PO
PO
PO
Parenteral
PO
PO, Parenteral
Parenteral
PO
PO
PO
PO
PO
PO
PO
PO

X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X

(

Route of
Administration
PO
Parenteral
PO

Pregnancy risk
category
D
D
B

PO, Parenteral
PO

D
C
D
D
C

Dilatrend
Celebrex

PO
PO
PO, Parenteral,
Topical
Parenteral
Parenteral
PO
PO
PO
Parenteral
PO
PO

Leukeran
Librax

PO
PO

D
D

Parenteral
PO, Parenteral
PO
PO, Parenteral

D
D
D
C

Codeine

PO

Colchicine

PO

Alprazolam
Amikacin
Amiloride
Amiodarone
Aspirin

Cordarone

Atenolol
Azathioprine
Betamethasone
Bleomycin
Dactinomycin
Capecitabine
Captopril
Carbamazepine
Carboplatin
Carvedilol
Celecoxib
Chlorambucil
Chlordiazepoxide +
Clidinium bromide
Cisplatin
Clonazepam
Clorazepate
Co-trimoxazole

Cosmegen
Xeloda
Tegretol

Tranxene

D
D
D
C
D
D
C
C

D; if used in pregnancy induced HTN

D; 
 3

D;   1

D;   2, 3

D;   2, 3
D;   3

D;   3

D;

( ( )

Route of
Administration
PO, Parenteral
Parenteral
PO, Parenteral
PO, Parenteral
Ophth, PO,
Parenteral
Topical
Parenteral
Parenteral
PO
PO
PO
PO
Parenteral
Parenteral

Pregnancy risk
category
D
D
C
D
B

Eye drop, Ear

drop

PO, Parenteral

Gemcitabine
Hydrochlorothiazide

Parenteral
PO

D
B

Hydrocortisone
Hydroxyprogesterone
Hydroxyurea
Ibuprofen

PO, Parenteral
IM
PO
PO

C
D
D
B

Parenteral

Cyclophosphamide
Cytarabine
Dexamethasone
Diazepam
Diclofenac

Docetaxel
Doxorubicin
Doxycycline
Efavirenz
Enalapril
Erlotinib
Etoposide
Fentanyl

Framycetin +
Gramicidin +
Dexamethasone
Furosemide

Idarubicin

Tarceva

Sofradex

ProlutonDepot
Hydrea

B
D
D
D
D
C
D
D
C

D;   1
D;   3

D;   2, 3

D; 


D;   1

D; if used in pregnancy induced HTN

D; if used in pregnancy induced HTN
D;   1

D;   3

( ( )

(
Ifosfamide
Imatinib
Imipramine
Indomethacin

Iodine
Irbesartan
Irinotecan
Kanamycin
Ketorolac
Labetalol
Levofloxacin
Lithium
Lorazepam
Losartan
Lugols solution
(Iodine + KI)
Medroxyprogesterone
caproate
Melphalan
Mercaptopurine
Methadone

Methimazole
Metoprolol
Midazolam

Route of
Administration
Parenteral
PO
PO
PO

Pregnancy risk
category
D
D
D
B

Ketolac

PO
PO
Parenteral
Parenteral
Parenteral

D
C
D
D
C

Avexa
Cravit

Parenteral
PO, Parenteral

C
C

PO
PO
PO
PO

D
D
C
D

Parenteral

PO
PO
Parenteral

D
D
B

PO
PO
Parenteral

D
C
D

Glivec

Aprovel
Campto

Cozaar

Proluton
depot
Alkeran
Puri-nethol

Betaloc
Dormicum

D;  > 48 
34

D;   2, 3

D;   3

D;   2, 3

 1

D;   2, 3

D; 


D;   2, 3

( ( )

Route of
Administration
PO, Parenteral

Pregnancy risk
category
C

Neomycin + Polymyxin Poly-oph

+ Hydrocortisone
Naproxen

Eye drop

PO

Netilmycin
Nilotinib
Norfloxacin

Parenteral
PO
PO

D
D
C

Nortriptyline
Ofloxacin

PO
PO

D
C

Oxaliplatin

Parenteral

Parenteral
Parenteral

D
B

PO, Parenteral
PO, Parenteral
PO, Eye drop
PO
PO
Cream
PO

D
D
C
C
D
C
C

Parenteral
PO

D
C

Morphine

Kapanol

Tasigna

Paclitaxel
Pethidine

Intaxel

Phenobarbitol
Phenytoin
Prednisolone
Propanolol
Propylthiouracil
Silver sulfadiazine
Spironolactone

Gardenal
Dilantin

Streptomycin
Sulfadiazine

D; 


D;   1
D:   3

 1

(
 1
D;   3

D; 

D;   1
D;   2, 3
D;   3
D; if used in pregnancy
induced HTN
D; 

( ( )

(
Sulfasalazine
Tamoxifen
Telmisartan
Tetanus antitoxin
Tetracycline
Timolol
Thioguanine
Tobramycin
Trastuzumab
Triamcinolone
Uracil+Tegafur
Valproic acid
Valsartan
Vinblastin
Vincristine
Vitamin D
Zoledronic acid

Micardis

Lanvis
Tobrex
Herceptin
Kenacort
Ufer
Depakine
Diovan

Zometa,
Aclasta

Route of
Administration
PO
PO
PO
Parenteral
PO
Eye drop
PO
Eye drop
Parenteral
Parenteral
PO
PO, Parenteral
PO
Parenteral
Parenteral
PO

Pregnancy risk
category
B
D
C
D
D
C
D
D
D
C
D
D
C
D
D
A

Parenteral

D; 
D;   2, 3

D;   2, 3

D;   1

D;   2, 3

D; 
RDA

1. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation.7th ed. Philadelphia:
Lippincott Williams & wilkins; 2005.
2. Lacy CF, Armstrong LL, Goldman MP, Lance LL. Drug information handbook. 17th ed. Ohio:
Lexi-comp; 2008-2009.
3. Fun LW, editor. MIMs Thailand. 100th ed. Bangkok: TIMS; 2005
4. DRUGDEX System. MICROMEDEX. Inc., Englewood, Colorado (Edition expires [2012]).

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