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Sampath Antibiotics
Sampath Antibiotics
-Lactam Antibiotics
A variety of penicillins have been produced by the fermentation
of Penicillium chrysogenum in the presence of different nutrients.
Penicillin G predominates when the culture medium is rich in
phenylacetic acid, whereas the incorporation of phenoxyacetic acid
favors penicillin V (phenoxymethylpenicillin).
Semisynthetic penicillins, such as ampicillin and amoxicillin, are
prepared by replacing the aromatic side chain of biosynthetically
derived penicillins with other chemical groups.
All penicillins are -lactam antibiotics and have the same
mechanism of action: They inhibit bacterial cell wall biosynthesis .
Bacterial cell walls differ from mammalian cell walls and are
therefore attractive targets for antibiotics. Bacterial cell walls
contain -lactam receptors , known as penicillin-binding proteins
(PBPs).
PENCILINE-G