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) Pharmacology (A.N.S. Dr. Mohsen: Autonomic Nervous System
) Pharmacology (A.N.S. Dr. Mohsen: Autonomic Nervous System
Mohsen
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autonomic nervous system
28 2013
4 22
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A 1
,, ,,
Chloramphenicol
,,
Chloramphenicol spelling ,,
Chloramphenicol 250
" ,,
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:
for how long
duration treatment
duration
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pharmacology ,, ,,
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:
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indications
indications
essentially
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: external
Internal
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,, experimental pharmacology
How to apply our knowledge experimental model
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clinical pharmacology
How to apply our knowledge
heart failure
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Maximum
,, No excuse
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Maximum MCQ
MCQ
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: gush !!!
: !!!
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:
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,, bronchi bronchi
: ,, ,, bronchi
....
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,, autonomic nervous system
,, ,,
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text
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Review
anatomy ,, anatomy
:
38
,, 52
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,, ) (
Involuntary structures
,, .C.V.S cardio vascular system Involuntary
,, Involuntary
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,, smooth muscle fibers
:
Eye
Bronchi
.G.I.T
Urinary system
Sex organs
Origin
Nerve
supply
,,
.C.N.S
autonomic nervous system sympathetic Para
sympathetic
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sympathetic thoraco lumbar
,, Origin
sympathetic thoracolumbar
para sympathetic cranio sacral
,,
Nerve
autonomic nerve : division 2
Pre ganglionic fibers
Post ganglionic fibers
ganglion ) (
sympathetic
pre ganglionic fibers ) ( short
Post ganglionic fibers ) ( long
ganglia lies near the spinal cord
para sympathetic
preganglionic fibers ) long (
Post ganglionic fibers ) short (
ganglia Near the organ even
embedded organ
,,
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origin sympathetic thoraco lumbar
Origin para sympathetic cranio sacral
,, nerve
Pre ganglionic
sympathetic short
para ganglionic Long
Post ganglionic
sympathetic long
para sympathetic short
ganglion
sympathetic Near the spinal cord
para sympathetic near the organ embedded in it
,,
Intestine ,,
Involuntary structure ,, S.M.F. << smooth muscle fibers
.G.I.T
supplied by sympathetic para sympathetic
sympathetic ganglion organ Near
sympathetic ganglia
Only Para sympathetic ganglion
isolated organ
Never sympathetic ganglia
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sympathetic supply para sympathetic
,,
supply cardio vascular .S.M.F
supply
,,
involuntary organs
) sympathetic para sympathetic
double innervation
(
Dual innervation
,,
sympathetic
sweat glands sympathetic
sweat gland
,,
Only sympathetic Para sympathetic innervation
sweat gland
blood vessel
blood vessel sympathetic
,, Para
,,
blood vessel sympathetic
Especially cutaneous blood vessel
) ,, (
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: sweat gland
blood vessel sympathetic
para blood vessels sex
organs Male erection
skeletal muscles para sympathetic
,,,
blood vessels para sympathetic
innervation
,,
: ventricle
vagal escape phenomenon
ventricle para sympathetic innervation
sympathetic
: ) Dilator pupillae muscle ( DPM
sympathetic
Dilator Pupillae muscle
sympathetic
: erection of hair
!!!
) Erectoepillae muscle ( pilomotor muscle
supra renal medulla
6 ,, sympathetic
,,
sweat gland
pilomotor muscle
cutaneous blood vessels blood vessels
:
Dilator Pupillae sympathetic
Ventricle sympathetic
Supra renal medulla sympathetic
,,
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sympathetic
,, Involuntary organs double innervation
With the exception of
Sweat gland
Erectoepillae muscle
Cutaneous blood vessels
Dilator Pupillae muscle
Ventricle
Supra renal medulla
,,
,,
,,
) autonomic nervous system is under control of CC ( cerebral cortex
Under control of limbic system
Under control of hypothalamus
full stop
,,
,,
,,
,,
autonomic nervous system
) ,,
,,
,, (
autonomic nervous system
system regulate Involuntary functions
involuntary functions
.C.V.S
.S.M.F
Eye
Bronchi
.G.I.T
Urinary
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( Pharmacology ) || ||
Sympathetic
Para sympathetic
,,
Para sympathetic :
constrictor pupillae muscle
sympathetic ,, :
,,
Review of physiology
pharmacology
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review of physiology
:
Function
function sympathetic
sympathetic
function para
:
autonomic nervous system
:
.S.M.F
.S.M.F ,,
glands
.C.V.S
effect of sympathetic stimulation .C.V.S
Heart blood vessels blood pressure
function of sympathetic heart
effect of sympathetic stimulation heart
Increase of all cardiac properties
cardiac properties
,,
Rhythmicity of the heart heart rate
rhythmicity
Contractility of the heart
contractility
conductivity of the heart to propagate nerve impulse
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Excitability of the heart
power of the heart to respond to external stimuli
automaticity
,, automaticity
power of the heart to respond Normal peace maker
,,
.S.A.N .A.V.N A.V. bundle bundle branch
Purkinje fibers
fibers
.S.A.N .A.V.N
automaticity
automaticity
,, rhythmicity ,, conductivity ,, excitability ,,, contractility
automaticity
blood vessels
,,
skin ) .M.M MM ( Mucous membrane
,,
coronary constriction
vaso dilatation coronary and skeletal
sympathetic fight fright
,,
blood supply
heart
blood pressure ,,
,, :
,,
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diastolic systolic
Pulse pressure
systolic ,, diastolic ,, mean blood pressure pulse
pressure
,,
,,
:
: Hypertensive effect
: vaso presser response
,, vaso presser
Hypertensive effect
,, sympathetic
,,
action similar sympathetic stimulation
Sympathomimetics
3 4 sympathomimetics
,,
sympathomimetics
: ,,
,, sympathomimetics
sympathomimetics
amphtamine
,, sympathomimetics
Dopamine
sympathomimetics
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,,
sympathomimetics
,,
sympathomimetics
,,
.S.M.F :
Eye
Bronchi
.G.I.T
Urinary
Sex organs
eye
,, bronchi
,, sympathetic stimulation bronchial dilatation
,, bronchial relaxation :
,, Dilatation bronchi
,, ,, air
broncho dilator effect
.G.I.T
Under sympathetic stimulation
Inhibition tone and motility
: tone and motility
:
sympathetic stimulation inhibition tone and motility
contraction sphincter
,, defectation
urinary
sympathetic stimulation urinary relaxation wall
contraction Trigone
delay evacuation urinary bladder
>> urine retention
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,, sympathetic relaxation of uterus
,,
relaxation of uterus labor
Sex organs Males
sympathetic process of ejaculation
Purely sympathetic
under sympathetic stimulation
ejaculation
,,
,,
ejaculation
Purely sympathetic
,, sympathomimetics
endocrine
ejaculation << sympathetic
eye
Eye
eye ,, eye
,,
eye ) iris ( ,,
iris
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Under sympathetic stimulation
Dilator pupillae muscle
contraction
) ( Pupil
mydriasis
Mydriasis
,, ,, energy consuming
active mydriasis
,,
field
,,
active mydriasis
sympathomimetics
active mydriasis
contract
Mydriasis active
,,
passive mydriasis
,,
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Under sympathetic stimulation
salivary gland viscid secretion
solid content water content
,,
viscid secretion
clinical application
,,
,,
sympathomimetics
,,
,,
sympathomimetics heart
: ( (
,, Intra cardiac
,,
) (
emergency bag
Intra cardiac
intensive care
MCQ
cardiac resuscitation
resuscitation
Heart failure
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dopamine
Heart failure
When digitalis fail
digitalis dopamine heart failure
sympathomimetics
heart failure
,,
brady cardia
sympathomimetics
blood vessels
,, : ,,
,, epistaxis
epistaxis
,, ,,
,,
,, vaso constriction Mucous membrane
blood vessels
,,
Hemostatic
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,, ,, 180/120
cerebral hemorrhage
,,
,, ,,
,, Hypertensive
blood pressure
vaso dilatation ,, coronary
,,
:
myocardial infarction
,,
,, angina coronary
sympathomimetics
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,,
pharmacological action
scope
sympathomimetics vaso dilatation coronary
Increase all cardiac properties
!!!!
,, Bronchi
,,
,,
expiratory wheeze
Wheeze rhonchi
,,
sympathomimetics
bronchi
,, sympathomimetics
.G.I.T
,,
,, can you use : sympathomimetics
diarrhea
) diarrhea (
,,
,,
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sympathomimetics diarrhea
sympathomimetics relaxation wall contraction
sphincter
,,
,,
,, ) ,, Motility
(
!! sympathomimetics !!!
tachycardia arrhythmia
symptomatic
,,
,,
,,
,,
,,
Nocturnal enuresis ,,
Nocturnal
Enuresis
Nocturnal enuresis
,,
,,
,,
,,
,,
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sympathomimetics
sympathomimetics
relaxation wall
contraction sphincter
sex organs
Male female
,, ,, ) uterus (
contraction ring
) ,, (
Contraction ring
,, ring
sympathomimetics
sympathomimetics
,,
relaxation Uterus
,,
tachycardia
sympathomimetics selective
selective
,,
selectivity Uterus
selectivity One organ
little effect No effect Other organs
Male
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: Male sympathomimetics ejaculation
sympathomimetics
ejaculation
,,
,, Eye
eye sympathomimetics Mydriasis
,,
,,
,,
fundus examination
,,
sympathomimetics
,,, ,,
,,, ,,
expose eye Light constrictor pupillae
Light effect
Pupillary constriction of one eye
And other eye
direct Indirect
pupillary constriction direct effect
pupillary constriction
Indirect effect
,, ,,
,, constrictor pupillae muscle
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eye
gland
para sympathetic
,,
,,
effect of para sympathetic
para sympathomimetics
acetyl choline
acetyl choline
:
acetyl choline Para sympathomimetics
>> Para sympathomimetics
Nicotine sypmathomimetics and para
sympthomimetics
A 1
3 09
29 2013
B 1
4 48
29 2013
acetyl choline Para sympathomimetics
>> Para sympathomimetics
Nicotine sypmathomimetics and para
sympthomimetics
Because it is ganglion effect
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para sympathomimetics
nicotine is ganglion stimulant
,,,
acetyl choline
Inderal
Inderal ,, Propranolol
blocker
beta
para sympathomimetics
,, muscrine Muscrine
) parathione ( ,, anti
cholinesterase
,,
,,
neostigmine para sympathomimetics
physostigmine
,,
,, para sympathomimetics
Heart
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para sympathomimetics Heart
,, heart rate contraction ,, atrium
,, ventricle
,, atrial conduction ) ( A.V. conduction
,,
:
:
,,
Inhibit ,, atrial conduction
blood vessels
blood vessels para sympathetic receptors ,,
Muscarinic receptors
blood vessels Para sympathetic
innervation
,,
blood vessels para sympathetic innervation
receptors
Modified areas Muscarinic receptors
,,
,, stimulation para sympathetic
division
blood vessels
,,
effect of para sympathetic stimulation blood
vessels
No effect :
: effect of para sympathomimetics blood
vessels
,, para sympathomimetics :
Muscarinic receptors
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vaso dilatation
,,
review of physiology
No effect
>> Pharmacologically specialized area receptors
vaso dilatation
no innervation of blood vessels
No effect
,,
,, para sympathetic
vaso dilatation
,, ,,
blood pressure
,, para sympathetic heart
bradycardia
bradycardia cardiac output
,,
,, bradycardia ,, Heart rate cardiac output
,,
sympathetic Increase of all cardiac properties
para sympathetic decrease all cardiac properties atrial
conduction
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para sympathomimetics
,,
:
para sympathomimetics are indicated in bronchial asthma
Indicated
bronchial asthma
wrong right
Wrong
,,
right para sympathomimetics are contra indicated in bronchial asthma
wrong
Right
.G.I.T
wall stimulation Para sympathomimetics
sphincter relaxation
evacuation
Urinary
stimulate the wall ,,
And relax the trigonal sphincter
sex organs
erection << Para sympathetic ,, Male
para sympathetic supplied blood vessels
male
Para sympathetic
Higher control
failure of erection
Para sympathomimetics
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females
para sympathetic innervation uterus
,,
Eye
,, Para sympathetic
supply constrictor pupillae
para sympathetic stimulation physiologically
pupillary constriction
Miosis
criteria coma
,,
,,
para sympathomimetics
eye
,, ) sclera (
cornea iris Pupil
,,
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,,
ciliary muscle
two attachement
:
,, angle canal of Schlemm
,, suspensory ligament
) ( Lens
,, Iris Pupil
,,
,, Ciliary muscle
para sympathetic
para sympathetic
constrictor pupillae
ciliary muscle
,,
ciliary muscle contraction
under para sympathetic stimulation
,,
,, canal of Schlemm
,,
) (
glaucoma
contraction
canal of Schlemm
intra occular pressure
,,
muscle contraction
,, ,,
convexity of anterior surface of the lens
accomodation to near object
para sympathetic ,, eye :
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,, glands
,, Under para sympathetic stimulation ) profuse ( watery
secretion
,, sympathomimetics
sympathomimetics
sympathomimetics
,, cardiac arrest
heart failure
bradycardia
epistaxis
,, ,,
bronchial asthma
contraction ring of uterus
Nocturnal enuresis ,,
,,
para sympathomimetics
para sympathomimetics
,, heart
tachycardia
tachycardia
paroxysmal tachycardia
paroxysmal atrial tachycardia
,, ,, reassurance
,,
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,, ,, ,, vagal stimulation
Heart rate
,,
Para sympathomimetics
,, blood vessels
no innervation
,,
bronchi
broncho constriction!!!!
para sympathomimetics bronchial asthma
.G.I.T
,,
,,, renal colic
: ,, ) (
!!!!
,, ,,
) ( Intestine
excessive handling tissues
paralytic ileus
paralytic ileus
,,,
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:
paralytic ileus
parayltic
ileus )
,, terminal ileum ileus
colic (
para sympathomimetics
Line
Line
para sympathomimetics neostigmine
) Prostigmine in resistant cases
controversial
,,
(
,, Urinary
,,
,,
) : (
,,
% 50 ,, senile
) enlargement of prostate
bengin prostatic hyperplasia senile enlargment of prostate
senile
,,
,,
(
,, bengin
,,
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,, )
(
relaxation
supra pubic region
,,
,, para sympathomimetics
24
: ) (
Injury Urethera
,, Urine
injury
,,
) ( neostigmine
Prostigmine
:
,, ,,
neostigmine prostigmine
:
:
,,
,,
,, ,, ,,
,,
atropine
,,
,, ,,
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,, Vial
Vial multiple doses
cc ,, 1 1 mg 1 ,,
,,
,,
,,
,,
,, vial vial
,,
ventilator
para sympathomimetics
secretion ,,
,,
) .N.B
,, para sympathomimetics
(
eye
,, para sympathomimetics
,, Glaucoma ,,
cataract
: glaucoma
glaucoma aqous
Diamox
,,
at the same time
,, canal
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para sympathomimetics
glaucoma
: Dry mouth
:
,, para sympathomimetics drug
profuse secretion
saliva
:
,,
tachycardia
paroxysmal tachycardia
paralytic ileus
Urine retention
glaucoma
dry mouth
,,
antagonism
antagonstic to each others
sympathetic << Increase all cardiac properties
para sympathomimetics << decrease all cardiac properties
atrial conduction
atrial conduction
atrial condction
: atrial conduction antagnostics
synergistic
39
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+ =
+ = !!!!
,,
,, atrial conduction
para sympathetic sympathetic
bronchi para sympathetic
sympathetic
,,
gland anatgnostics
solid content water content
* ,,
sympathetic and para sympathetic are antagonstic to each others
: except two situtations
atrial conduction
glandular tissue
,, source
,, ,,
,, autonomic nervous systme system
regulate involuntary structures
,, ,, .C.V.S smooth muscle fibers
eye, bronchi, G.I.T., urinary and sex organs
autonomic nervous system sympathetic para sympathetic
review of anatomy
40
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,, sympathetic Pre ganglionic short
Post ganglionic Long
sympathetic ganglia near thte spinal cord
Organ sympathetic ganglia
isolation Organ
,, sympathetic ganglia
sympathetic ganglia
,,
sympathetic ganglia Near the spinal cord
pre ganglionic short Post ganglionic Long
organ ,, animal
sympathetic ganglia
,,
,, para sympathetic ganglia Isolated
organ
para sympathetic Pre ganglionic Long
Post ganglionic short
,, isolated organ Heart Organ
para sympathetic ganglia
,,
review of anatomy
,, involuntary structures ,, .C.V.S .S.M.F smooth muscle
,, fibers exocrine gland salivary gland double innervation
sympathetic Para sympathetic
involuntary double innervation
sympathetic and para sympathetic
sympathetic para sympathetic
with the exception of
sympathetic
sympathetic
blood vessels cutaneous sympathetic
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,,
sweat gland <<< sympathetic
ventricle sympathetic
supra renal medulla sympathetic
) Erectoepillae muscle ( pilomotor muscle sympathetic
eye dilator pupillae muscle sympathetic
,, sympathetic
sympathetic
,, ,,
sweat gland .M.C.Q sympathetic
,, sweat gland
) Erectoepillae muscle ( pilomotor muscle sympathetic
blood vessels cutaneous sympathetic
dilator pupillae muscle sympathetic
ventricle
supra renal medulla
review of physiology
item reveiw of physiology
sympathetic Para sympathetic function
physiology function
an idea about
pharmacology
similar to sympathetic stimulation
sympathomimetics
action similar to para sympathetic stimulation
para sympathomimetics
clinical applications
sympathetic heart
42
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,, ,,
sympathomimetics heart
,, Imagination
heart
,, bradycardia
,, heart failure dopamine ,,
Heart
sympathomimetics
sympathetic
heart attack
heart attack
,,
cardiac arrest :
,, ,,
Intensive care
,,
Intra cardiac
,, cardiac resuscitation
blood vessels
,, epistaxis
,, Locally sympathomimetics vaso constriction
sympathomimetics ,, bronchi
bronchi
bronchial asthma
,, urinary
sympathomimetics relaxation wall contraction
sphincter
43
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,, Incontence of urine
,, sympathomimetics relax wall
contraction sphincter
Uterus ,,
uterus contraction ring of
uterus
sympathomimetics
para sympathomimetics clinical application
physiology function of para sympathetic
heart inhibition atrial
conduction
:
,, ,,
,, : atrial conduction
cardiovascular
clinical application
clinial application
stress
tachycardia
tachycardia
carotid vagal stimulation
heart rate
,,
para sympathomimetics
heart rate
,,, ,, ,,
Physiological measure
reassurance ,,
para sympathomimetics
44
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,,
,,
blood vessels
para sympathetic stimulation blood vessels
no effect para sympathetic innervation blood vessels
,,
,, erection male para
sympathetic
blood vessels para sympathetic
,,
) ( Pharmacology
,, para sympathetic drug vaso dilatation
para sympathetic heart
Inhibit cardiac properties atrial conduction
45
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,,
para sympathomimetics
,, ,, bronchi
.G.I.T
,, general surgery
paralytic ileus
,,
,, ,,
,,
,, excessive handling tissues
tone
paralytic ileus
,, para sympathomimetics Motility
) controvesial (
,, Motility
,, Urinary
,, ,,
para sympathomimetics
para sympathomimetics stimulation wall
relaxation sphincter
,,
,, Urine
retention
para sympathomimetics
be sure obstruction below
) ( impacted
Urine retention Obstruction
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para sympathomimetics
,, para sympathomimetics
contraction Urinary bladder
inter vesical pressure
rupture of urinary bladder
,,,
in obstructive urine retention the best drug to best drug to be given is
,,
,, neostigmine
para sympathomimetics
Non of them
Non of them ,,
Neostigmine Urine retention Obstructive
,,
none of the above
Non of them
None of them
.M.C.Q
5 35 1 2013
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www.facebook.com/dr.tafreegh
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