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NLME Infection
NLME Infection
infection
Host
DM, thalassemia, chronic renal failure
Burkholderia pseudomallei
encapsulated organism S.pneumoniae H.influenza
infection
infection
identify microorganism
S. auereus
antibiotic cloxacillin dicloxacillin
Klebsila pnuemoniae antibiotic 3 generation
rd
cephalosporin ceftriazone
drug resistance
fever 2-3
replication influenza
septic arthritis most common S. aureus rheumatic
Infection
pneumonia; stiffneck positive
meningitis; ( focal neurodeficit)
Brain abscess; (orthopnea)
acute rheumatic fever infective endocarditis;
acute pyelonephritis;
septic arthritis
common Acute
common
empirical antibiotic gram stain
culture
anthrax
(Bacillus
anthraxis) malleoidosis
leptospirosis
rabies Pasturella sp.
mucor DM sinusitis
rhinocerebral mucormycosis
penicillin -lactam cross reaction
immunocompromised host antibiotic
cell
bacteriocidal
wall cell membrane immune
bacteriostatic cidal
Antibiotic metabolism
hepatic function renal function
-lactam 2
ceftriaxone cloxacillin
dose
antibiotic term In
vivo In vitro test In vitro effect
(In vivo) In vitro In vivo
volume of distribution
In vitro blood concentration
dose
In vivo tissue concentration
tissue
Macrolide
Quinolone
intracellular
organism
Mycoplasma
antibiotic
o Inactivation enzyme
-lactamase
modifying enzyme
aminoglycoside
-lactam
protein
drug
4. Pharmacodynamic
interaction side effect
inhibit
cell
wall
synthesis
inhibit
macrolide,
bacteriostatic
Penicillin
Penicillin
Treponema pallidum syphilis
syphilis chancre (
Leptospira
spp.
leptospirosis
organ failure Weils syndrome
antibiotic of choice penicillin
Aminopenicillin amino group cover
gram
negative
H.influenza
amoxicillin () ampicillin ()
enzyme penicillin penicilinase
S. auereus
10
Neisseria meningitidis
11
Cloxacillin cloxacillin
dicloxacillin
staphylococci
Cloxacillin dicloxacillin cover strep staph.
septic
arthritis,
osteomyelitis
carboxypenicillin
Carbapenem imipenem
12
cilastin
inhibit
renal
dihydropeptidase I imipenem
aztronam
Cephalosporin
Cephalosporin 4 generation
1 generation cefazolin cefa spectrum
st
nd
rd
Pseudomanas aeruginosa
13
Quinolone
nd
Norfloxacin
GI tract
infective diarrhea Ofloxacin
UTI
Ciprofloxacin quinolone
Pseudomonas aeruginosa
pneumonia cell quinolone
Levofloxacin
rd
14
cover respiratory tract organism
H.influenza
gram-ve diplococci
walking pneumonia
consolidation bacteria
pathology
interstitial
AIHA
antibody
infect
IgM
tympanic membrane
skin lesion Erythema multiforme Target
lesion ()
Mycoplasma
quinolone activity
intracellular
organism
Mycobacterium
15
Macrolide
3
roxithromycin, clarithromycin, azithromycin
treat
atypical
pathogen
Aminoglycoside
amino group
GI tract
16
aminoglycoside
Streptomycin,
Neomycin
aminoglycoside 30S
ribosome
Vancomycin
vancomycin
methicillin-resistant Staphylococcus aureus (MRSA)
MRSE coagulase ve staphylococcus (Staph 2
species
S.aureus
coagulase
+ve
Clindamycin
17
Metronidazole
anaerobe
diaphragm
Drug interaction
interaction
antibiotic
antibiotic
drug
18
Side effect
Side effect
-lactam
hypersensitivity
anaphylactic shock
BP drop lung wheezing
anaphylaxis
adrenaline
hypersensitivity
19
20
o Ototoxicity vesibular
toxicity irreversible vertigo ataxia
scenario
1. 25
erytrymatous
antibiotic ?
-
cellulites
clarify
S.aureus
border
21
endocarditis S.aureus
cloxacillin
antibiotic
3. 50
3 5
antibiotic of choice ?
- leptospira antibiotic of choice Penicillin
4. 25 dyspnea 3
x-ray diffuse interstitial infiltration severe hypoxia
ARDS antibiotic of choice ?
co-trimoxazole
22
6. 25
hepatosplenomagaly
right
upper
quadrant
- thalassemia
abscess melioidosis antibiotic of choice ceftazidime
7. 40
tender hepatomagaly single
lesion antibiotic ?
- amebic liver abscess antibiotic of choice
metronidazole
8. 25
hypovolemic shock antibiotic of
choice?