Multipl

Jaymee B. Quindara
College of Medicine
Mariano Marcos State University

Multiple Sclerosis

Autoimmune
Demyelination
Myelin Sheath

Oligodendrocytes

Node of Ranvier
Conduction problems

Normal Anatomy of the CNS

Chronic Lesions

Acute Attack

Abnormal Impulse Conduction

Slowed Conduction
Dispersion of Conduction
Increased Sensitivity of
Conduction
Blocked Conduction

Musculoskeletal

Fatigue
Limb weakness
Dragging of foot and foot drop
Spasticity
Intention tremors
Muscular atrophy
Ataxic movements
(shaky, irregular, uncoordinated)
Dysarthria with slurred speech

References:
Blumenfeld, Hal. Neuroanatomy through Clinical Cases, 2nd ed.
Sinauer Associates. 2010.
Burke et, al. Medical Surgical Nursing, 5th ed. Pearson. 2011
Fauci et, al. Harrisons Principles of Internal Medicine, 19th ed.
McGraw Hill. 2015
Klein et, al. Adams and Victors Principles of Clinical Neurology,
10th ed. McGraw Hill. 2014
Snell, Richard. Clinical Neuroanatomy, 7th ed. Lippincott Williams
Wilkins. 2010