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Organism: Body systems that are all integrated into one living thing.
System: A group of organs that work together for a common purpose. For
example the respiratory system.
Organs: Two or more tissues make up an organ. The lung is an example of an
organ.
Tissues: Specialised cells that carry out a common function. e.g. a group of
muscle cells make up muscle tissue.
Cells: Basic unit of the body. Carry out different functions. Red blood cells,
white blood cells, etc.
The basic structural and functional unit of a living organism.
Organelles: Structures that carry out specific functions inside a cell.
Cytoplasm is a jelly-like substance that makes up the cell. This substance suspends
organelles in the cell.
Organelle Functions
Endoplasmic reticulum: Membranes of E.R provide a surface for chemical
reactions to occur on.
Endocytosis: The process by which the vesicle is formed. A cell surrounding some
extra-cellular material with a fold of cell membrane, the enfolding membrane then
breaks away. The material is enclosed within the cell in the form of a small bubble
liquid sac which is called a vesicle.
Two forms of endocytosis include:
Phagocytosis (cell-eating) : This is when the material engulfed includes solid
particles.
Pinocytosis (cell-drinking) : Material taken in is liquid.
Exocytosis: Process in which the contents of a vesicle are pushed out through the
cell membrane. The membrane around the vesicle fuses with the cell membrane
and the vesicle contents are pushed out to the exterior.
Transport Mechanisms
Passive Transport: Cells energy does not have to be used to transport materials
which come in/out of the cell.
Active Transport: Requires cell's energy for transfer of materials to occur.
Cell membranes are differentially permeable which means they allow certain ions
and molecules to pass through, but restrict movement of others.
Three basic processes that result in transport of materials into, or out of the cell:
Diffusion:
Carrier mediated transport
3. Vesicular transport
facilitated diffusion. This is a passive process that moves substances from a high
concentration on one side of the membrane to a lower concentration on the
opposite side.
This is a type of carrier mediated transport in which the transported molecule
binds to a carrier protein which then changes shape to move the molecule to
the opposite side of the membrane where it is released.
Once all the carrier molecules are in use the process cannot go any faster
which make sit slower than simple diffusion.
All cells transport glucose molecules through their membranes by facilitated
diffusion.
Active Transport is the movement of substances across the cell membrane against
the concentration gradient using cellular energy. Substances that are more
concentrated inside the cell can still be absorbed. In the same way, some less
concentrated materials can be exported from the cell.
Energy for the cell's active processes come from the mitochondria. At the
mitochondria cellular respiration breaks down glucose to release energy that the
cell can use.
Vesicular Transport
An active process in which materials move in/out of the cell through vesicles. Two
basic types of vesicular transport includes endocytosis and exocytosis.
Metabolism
All the chemical reactions that occur in the body. Made up of two different types of
chemical reactions: catabolism or anabolism.
Factors which affect enzyme activity rate include temperature and pH. Enzyme
activity decreases at pH levels higher or lower than the required level. Enzymes also
have an optimum working temperature. In humans that is a temperature of 37*C.
Cellular respiration is a metabolic process which occurs in any cell. It is a process
by which organic molecules, taken in as food, are broken down in cells to release
energy for the cell's activities. Cellular respiration is a chemical process and is not to
be confused with respiration (breathing).
The main material involved with cellular respiration is glucose (C6H12O6)
Respiration can be summarised as an equation:
C6H12O6 + 6O2
6CO2 + 6H2O + energy
The breakdown of glucose to carbon dioxide and water involves over 20 reactions
which occur sequentially one after the other. At each step a compound is formed
and catalysed by a different enzyme. Small amounts of energy are released as the
reactions proceed. The release of energy is controlled and does not occur at once.
There are three main processes in cellular respiration:
1. Glycolysis
This is the first step in which one glucose molecule is broken down, in a series of ten
steps, into two pyruvate molecules. Glycolysis occurs in the cell's cytoplasm and is
an anaerobic process in that it requires no energy. Pyruvic acid is then converted
Energy from cellular respiration is important as the body uses this energy as heat energy to keep
the body at a constant temperature. The remaining energy is used to form ATP (adenosine
triphosphate)
Adenosine triphosphate is formed when an inorganic phosphate group is joined to a
molecule of adenosine diphosphate. The phosphate groups in ATP are joined by high chemical
bonds. Some of the energy from cellular respiration is stored in the bond between the ADP
molecule and the third phosphate group.
The cell's nucleus contains DNA which carry genetic information that determines the structure of
the cell. DNA (deoxyribonucleic acid) molecules are in the form of long strands and have a twisted
spiral shape in called a double helix.
The DNA is made up of bases known as nucleotides that are attached to sugar and phosphate
molecules. Nucleotides are the units that make up the DNA structure:
Each strand of DNA is bound to special proteins called histones. DNA strands are coiled around the
histones so that these long molecules can fit into a small space. In a cell that is not dividing the
coiled DNA forms a tangled network called chromatin.
When a cell divides, exact copies of each DNA molecule in the tangled mass of chromatin is
distributed to the daughter cells.
Mitosis
The division of the cell in which the nucleus is divided and ensures that each body cell recieves
exactly the same DNA as that possessed by the parent cell.
Interphase: DNA molecules duplicate. Molecules form exact copies of themselves. The
quantity of DNA in the nucleus doubles between one cell division and the next.
First stage of mitosis after interphase. Pairs of centrioles become visible and move to
opposite ends of the cell.
Chromatin coils to become chromosomes.
Nucleolus and nucleus break down.
Spindle fibres grow from centrioles.
Centrioles move to opposite poles of the cell.
Metaphase
Anaphase
Telophase
Protein synthesis
During interphase, the DNA molecules undergo the process of replication; form exact copies of
themselves. The two linked chains of DNA molecule separate and each seperated section contains
half of the original information, which serves as a template for the nucleotides that will form in the
new half.
DNA carries genetic code which provides instructions for protein synthesis (combining of amino
acids to form large protein molecules). Protein that is made is essential for chemical reactions that
occur in the cell which are controlled by enzymes which are also proteins. Proteins are also
important as they make up most of the structural materials of cell.
The specific types of proteins that can be made are determined by genes. The order in which the
four bases (adenosine ,thymine, cytosine and guanine) occur in a DNA molecule is the genetic code.
Each of sequence of the three base is the code for a particular amino-acid.
Amino acids are assembled at the ribosomes in the cytoplasm of the cell. Instructions/information
contained in the DNA located in the nucleus must be accurately transferred to the ribosomes.
The information is gotten form the DNA to the ribosomes via the RNA (carries the message).
RNA differs from in DNA in that it is only a single strand of sugars and phosphates and thus
the bases occurs singly. RNA also contains the base uracil (U) instead of thymine.
During protein synthesis the DNA unzips, separating its bases with the help of an enzyme.
Messenger RNA move in and take a copy of one side of the DNA strand. Then it moves out of the
nucleus heading for the ribosome. Ribosomes are organelles found attached to the endoplasmic
reticulum or surrounding the cytoplasm. They help build protein molecules from amino acids.
The messenger RNA attaches itself on to the ribosomes while the transfer RNA brings the correct
amino acid to ribosome. The three bases of messenger RNA found on the ribosome must match up
with the three bases on the transfer RNA before the right amino acid is found. The three bases on
the ribosomes are called a codon/triplet. The body has 22 different kinds of amino acids. They
combine to form a protein molecule.
Cell differentiation
It is the process in which unspecialised cells develop characteristics and functions of particular
types of cells.
Cell expansion
Multiplication or reproduction by cell division of a population of identical cells descended from a
single progenitor.
Transcription: Formation of complementary RNA.
Translation: synthesis of RNA using a DNA molecule as the blueprint. There is a corresponding RNA
nucleotide for each DNA molecule.
Messenger: copies info to ribosomes
Transfer: brings amino acids from the cytoplasm to the ribosomes.
Cells need nutrients to supply energy and matter for synthesis. These nutrients may be
organic or inorganic.
There are six groups of nutrients:
1. Water : fluid in which other substances dissolve in. water molecules take part in some
reactions.
2. Carbohydrates: main source of energy for cells. Complex carbohydrates are broken
down into simple sugars through the process of cellular respiration and in turn release
energy.
3. Lipids (fats): broken down to fatty acids and glycerol which enter the glycolysis
pathway and is broken down to release energy.
4. Proteins: Broken down into amino acids. Most important proteins made are enzymes.
Enzymes control metabolism by controlling the rate of chemical reactions that occur in
the body. Proteins can also be used as a source of energy, only if there is an
inadequate amount of carbohydrates or lipids.
5. Minerals: Part of enzymes. May function as co-factors of enzymes or may be part of
substances like ATP that are involved in metabolism.
6. Vitamins: Act as co-enzymes for many chemical reactions of metabolism.
Organic Substances
Contain large amounts of carbons.
Large molecules.
Most carbon contain carbon, hydrogen and oxygen ONLY!
e.g. Glucose
Sucrose
*Twice as many hydrogen as oxygen ALWAYS.
Monosaccharides are simple sugars. These are sugars such as glucose, fructose and
galactose.
Disaccharides are two simple sugars joined together. (i.e. sucrose, maltose and lactose)
Polysaccharides are large numbers of simple sugars joined together ( e.g. starch, glycogen
and cellulose)
Protein
*Contains carbon, hydrogen, oxygen and nitrogen (may have sulfur or phosphorus)
*Amino acids are the building blocks of protein. They are needed to be absorbed by cells.
*Amino acid + Amino acid = Dipeptide bond
*10 or more bonds are known as polypeptide bonds.
*Proteins consist of 100 or more peptide bonds.
Lipids
Same 3 elements as carbohydrates
Larger molecules - a smaller amount of oxygen compared to carbon and hydrogen.
Lipids - fatty acids + glycerol
Saturated or Unsaturated
Nucleic acids
Contain carbon, hydrogen, oxygen, nitrogen and phosphates.
Made up of smaller units called nucleotides(sugar phosphate and nitrogen base)
Vitamins
*Organic compounds
*Don't supply energy but are needed for energy release from carbohydrates,proteins and lipids.
(vitamin D and Vitamin E)
Non-organic substances
Minerals e.g. calcium, iron, phosphate, potassium and sodium
Water (H2O)
Essential for body functions
A balanced diet
Involves getting the correct amount of all the nutrients required for the body to function at its
optimum level.
*Malnutrition: Occurs when you do no not get the correct amount of all nutrients required. They
may be deficient in certain areas (e.g. proteins, vitamins, minerals, etc)
Factors affecting a balanced diet include:
Basal Metabolic Rate
Amount of energy needed when body is at rest during metabolism.
Level of activity
Age
Gender
Digestion
Body cells require simple sugars, amino acids, fatty acids, vitamins and minerals and water in order
to function properly. Vitamins, minerals and water are in the form of small molecules and are able to
pass through the differentially permeable membrane surrounding each cell. Carbohydrates,
proteins and fats are larger molecules which need to be broken down into smaller particles which
can be absorbed by the cell.
Digestion is the process where large carbohydrate, protein and fat molecules are broken down into
smaller particles by physical and chemical means in order to be absorbed by the blood and into the
cells.
The organs of the digestive system are structured to carry out six basic activities:
1. Ingestion of food and water
2. Mechanical digestion of food
3. Chemical digestion of food
4. Movement of food along the alimentary canal
5. Absorption of digested food and water into the blood and lymph
6. Elimination of material that is not absorbed.
Mechanical digestion
Breakdown into smaller particles.
e.g.:
Teeth: Physical process; breaking & grinding food.
Stomach: Churning and mixing
Muscle: Peristalsis (a series of wave-like muscle contractions that moves food (bolus)
down the oesophagus and through the intestines.)
Bile: Increases surface area; emulsifies fats
Chemical digestion
Breakdown of food molecules into smaller, simple molecules by the action of enzymes.
Mouth (saliva)
^Salivary amylase- breaks down starch molecules into smaller units.
Stomach (gastric protease = protein broken down into polypeptides (amino acids)
Small intestine: Intestinal amylase, protease, lipase
The Mouth
Saliva
The intake of food is known as ingestion. It occurs at the mouth.
The action of the jaw and teeth begins mechanical digestion where the food is broken
up into small pieces.
As the food is chewed it is mixed with saliva. A fluid which is secreted by three pairs of
salivary glands. It contains mucus and a digestive enzyme, salivary amylase which
begins chemical digestion of starch.
After chewing, the food is formed by the tongue into a lump (bolus).
It is then swallowed as the tongue moves backwards and upwards,
pushing the food into the back of the mouth, the pharynx. The
pharynx leads into the oesophagus (23-25 cm long) that connects the
pharynx to the stomach.
The stomach
From the oesophagus the food enters the stomach which has a jshape. When empty the stomach lies in longitudinal folds known as a
rugae.
The stomach lining is made up of mucosa which is specialised for the
secretion of gastric juice. Gastric juice is secreted by gastric glands
located in gastric pits in the mucosa.
Gastric juice contains HCl, mucus and digestive enzymes which are secreted by different cells
in gastric pits. The stomach has an oblique muscle layer allowing it to contract in a variety of
ways to churn food and mix it with gastric juice.
The food is then converted to a thick 'soupy' liquid called chyme.
Most of the chemical digestion in the stomach deals with the start of protein digestion.
The enzyme pepsin (gastric protease) breaks the bonds between certain amino acids, forming
smaller polypeptides.
Pepsin is secreted in an inactive form (pepsinogen) before it is activated when it comes into
contacted with HCl (low pH)
Protein stays in the stomach longer which leads to more efficient protein digestion.
The low pH kills bacteria entering the stomach with food.
In infants, rennin is also secreted which coagulates ( changes to solid) protein in the milk.
Nutrients are not absorbed into the blood through the stomach as the internal surface is
covered by a thick layer of mucus. However, some alcohol and a few drugs may be absorbed
by the stomach.
At the lower end of the stomach is a thickening of circular muscle which results in constriction
known as the pyloric sphincter. This sphincter prevents the stomach contents moving through,
or intestinal content from flowing back.
After 2-8 hour the stomach contents are gradually pushed into the next part of the alimentary
canal, the small intestine.
The first part of the small intestine is the duodenum; which is 25cm long and extends from the
bottom end of the stomach in a curve around the pancreas.
Digestion continues in the small intestine by the influence of: 1. intestinal juice which is secreted by the lining,
2. pancreatic juice which is secreted by the pancreas.
3. bile which is secreted by the liver but is stored in the gall bladder.
The mucosa and sub mucosa are modified to suit the functions of the small intestine. Both layers
have permanent folds that extend into the interior of the small intestine.
Mucosa has finger-like projections extending form folded surface known as the villi. Microscopic
projections, called microvilli project the external surface area of the villi.
These three modifications: folding, villi & microvilli serve to greatly increase the internal surface
area.
The main mixing movement in the small intestine is segmentation. Circular muscle fibres contract
forming segments. Contents of the small intestine are 'sloshed' back and forth mixing with digestive
enzymes.
Pancreatic juice, which has a pH of 8, enters the duodenum and helps to neutralise the acid that has
come with the material from the stomach.
Many enzymes are involved in digestion of food are contained in pancreatic juice. These include:
Pancreatic amylase: Breaks down starch into disaccharides
Trypsin ( pancreatic protease): splits proteins into smaller units
Ribonuclease & deoxyribonuclease: Digest RNA and DNA
Pancreatic lipases: Enzymes that breakdown fats into fatty acids and glycerol
Substances that are absorbed into the are carried to the liver via hepatic portal vein.
In the liver, they may be removed for processing or carried to other blood cells.
Fats absorbed into the lacteals are transported in the lymph system, which empties the blood.
Liver
Movement of materials through the large intestine is very slow (18-24 hrs.). During this time most of
the remaining water is absorbed, so that the contents become more solid.
Colonic bacteria (micro flora) break down much of the remaining organic compounds. Some bacteria
produce vitamins, which are then absorbed through the walls into the blood. Mineral nutrients are
also absorbed. In addition, short chains of fatty acids are produced in digesting fibre. They are also
vital for proper function of the colon.
The semi-solid material left after water absorption and bacterial action makes up faeces.
The Rectum
The semi-solid material in the colon is pushed by peristalsis into the rectum. As the rectum
stretches, it triggers a response to defecation - the emptying of the contents of the rectum.
Expelled faeces contain:
Water
Undigested food material, particularly cellulose
Protease
Lipase
Enzyme
Salivary Amylase
Pepsin
Pancreatic Lipase
Source
Salivary Glands
Chief cells in
stomach lining
Pancreas
Substrate
Starch
Proteins
Triglycerides such
as fats and oils
Products
Maltose
Small
polypeptides
Optimum pH
pH 7
pH 1.5 - 2
pH 7
Circulatory System
The circulatory system acts as the body's internal transport system which circulates blood flow
throughout the body. It is the link between cells inside the body, which have certain requirements
and the environment outside the body to supply those requirements.
The Heart
The heart is an organ which acts as a pump to push blood around the body. It is located in the
middle of the chest cavity between the two lungs. The right atrium is bigger than the left.
Around the heart is a membrane called the pericardium which acts to hold the heart in place but
allows the heart to move as it beats. This muscle prevents the heart from overstretching.
The wall of the heart is made up of a special type of muscle, called the cardiac muscle.
Circulation of Blood
Double circulation: This is the process in which blood passes through the heart twice. As explained in
the diagram below blood from the body enters the right atrium and into the right ventricle with the
aid of the tricuspid valves. The blood then enters the pulmonary artery and into the lungs. The blood
then returns to the heart via the left atrium and into the left ventricle. The blood then moves into
the aorta which transfers the blood back into the heart.