PARAXANTHINE

KELOMPOK C-1

Waktu

C paraxanthine

ln C
paraxanthine

0.5
1
1.5
2
4
6
8
10
12
24

0.087914987
0.114601858
0.155029781
0.273707596
0.49419311
0.563353018
0.299756369
0.413686762
0.298599752
0.196389968

-2.431384992
-2.166291264
-1.864138043
-1.295694909
-0.704828927
-0.573848817
-1.204785237
-0.882646205
-1.208651225
-1.627652964

C
residua
l
mutlak

Waktu

ln C

C
residua
l

0.07465
-0.0926

0.9280
68
0.9115
58

0.9280
68
0.9115
58

0.9280
68
0.9115
58

0.11055

0.8953
42

0.8953
42

0.8953
42

0.5
1

Ln C
residu
mutlak
0.0746
5
-0.0926
0.1105
5

Parameter farmakokinetik
Persamaan kurva eliminasi y = -0.0359x - 0.07465
Kel
= 0.0359 /jam

t
Vd
Cl

0.693
0.0359/ jam
= 19.30362 jam
= 0,5 L/kg (literatur)
= Kel Vd
=

= 0,0359 jam-1x 0.5 L = 0.01795 L/kg.jam

Co
= e0.07465
= 1.0775 ppm
Intercept
= 0.07465
Persamaan
Ka
Intercept
tpeak

kurva absorbsi y = -0.1729x - 0.0856

= 0.1729/jam
= 0.0856
=
x
=
= 11.36 jam

KELOMPOK C-2
Waktu

C
paraxanthine

ln C
paraxanthine

0.5
1
1.5
2
4
6
8
10
12
24

0.236815068
0.290092812
0.270270865
1.145359131
0.842158863
0.355284063
0.363257239
0.315549867
0.184583426
0.048735069

-1.440475746
-1.237554367
-1.30833062
0.135718239
-0.171786609
-1.034837632
-1.012644047
-1.153438552
-1.689653742
-3.021356406

Waktu

0
0.5
1
2

ln C
0.074
65
0.092
6
0.110
55
0.146
45

C
residu
al

C
residu
al
mutlak

0.9280
68

0.9280
68

0.9280
68

0.9115
58

0.6747
43

0.6747
43

0.8953
42

0.6052
49

0.6052
49

0.8637
69

0.5934
98

0.5934
98

ln C
residu
al
mutla
k
0.074
65
0.393
42
0.502
12
0.521
72

Parameter farmakokinetik
Persamaan kurva eliminasi y = -0.1184x - 0.161
Kel
= 0.1184 /jam
t
=

Vd
Cl

= 5.853 jam
= 0,5 L/kg (literatur)
= Kel Vd

= 0.1184 jam-1x 0.5 L = 0.0592 L/kg.jam

Co
= e0.1184
= 1.1257 ppm
Intercept
= 0.161
Persamaan
Ka
Intercept
tpeak

kurva absorbsi y = -0.1997x - 0.1982

= 0.1997/jam
= 0.1982
=
x
=
= 6.4299 jam

KELOMPOK C-3
Waktu

C
paraxanthine

ln C
paraxanthine

0.5
1
1.5
2
4
6
8
10
12
24

Waktu

0.175852722
0.270065211
0.162373337
0.388761745
0.364790386
0.366695923
0.39519944
0.442183258
0.383591252
0.130861895

ln C

-1.73810844
-1.309091827
-1.817857045
-0.944788604
-1.008432376
-1.003222321
-0.92836473
-0.816030872
-0.958177742
-2.03361275

C
residua
l

C
residua
l
mutlak

ln C
residual
mutlak

0
0.5
1

0.0746
5
0.0926
0.1105
5

0.9280
68
0.9115
58

0.9280
68
0.7357
05

0.9280
68
0.7357
05

0.07465
0.30693

0.8953
42

0.6252
76

0.6252
76

0.46956

Parameter farmakokinetik
Persamaan kurva eliminasi y = -0.0879x + 0.0784
Kel
= 0.0879 /jam
t

Vd
Cl

= 7.884 jam
= 0,5 L/kg (literatur)
= Kel Vd

= 0.0879 jam-1x 0.5 L = 0.04395 L/kg.jam

Co
= e0.0784
= 1.0812 ppm
Intercept
= 0.0784
Persamaan kurva absorbsi y = -0.3949x - 0.0863
Ka
= 0.3949/jam
Intercept
tpeak

= 0.0863
=

=
= 4.894 jam