Exam question 11

Classification
1. natural alkaloids- atrophine, hyoscine
2. semisynthetic derivatives- homatropine, ipratrepium bromide, tiotropium bromide
3. synthetic compounds
pharmacological effects
1. increase intraocular pressure(glaucoma)
2. dilation of pupils
3. decrease lacrimation
4. in GIt it reduces tone and motility of smooth muscle, gastric acid secretion
5. bradycardia due to stimulation of cardio inhibitory center in medulla
6. inhibition of saliva, lacrimation and sweat glands
7. bronchodilation and inhibition of bronchial secretion
THERAPEUTIC USES
1. atropine- antispasmodic for intestine, bilary and renal colics, locally in eye to
prevent formation of adhesion
2. peptuc ulcers
3. preanethetic drugs
4. parkinsons
5. motion sickness
6. decress bronchoconstriction in asthma
7. acid-peptic disease
ADVERSE EFFECTS
1. dry mouth
2. tachycardia
3. blurring vision, photophobia
4. urinary retension
5. hallucination, delirium
CONTRAINDICATION
1. in infants-hyperthermia
2. patient with tachycardia
3. patients with glaucoma