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Regulatory Substance of Gi Tract
Regulatory Substance of Gi Tract
RY
SUBSTANC
E
SOURCE
Gastrin
G cells
(Antrum of
Stomach)
D cells
(Pancreas)
Somatostati
n
FUNCTION
Cholecystoki
nin
I cells
(Duodenu
m,
Jejunum)
Secretin
S cells
(Duodenu
m)
GIP(Glucose
-Dependent
Insulinotropi
c Peptide)
Motilin
K cells
(Duodenu
m,
Jejunum)
Small
Intestine
VIP(Vasoacti
ve Intestinal
Polypeptide
)
Parasym
gangliain
sphincters,
gall
bladder
and small
intestine
Inc Gastric H+
Secretion
Inc Gastric Motility
Inc Growth of
Gastric mucosa
Migratory Motor
Complexes
REGULATION
NOTES
Inc by Gastric
distension,
Alkaline ph,
peptides, amino
acids, Vagal
Stimulations
Dec by pH<1.5
Inc by Acid
Dec by vagal
Stimulation
Inc in
Chr
Atrophic
Gastritis
ZE Synd
Chr PPI use
Inc by Fatty
Acids , Amino
Acids
Increased by
Acids, Fatty
Acids in lumen
of duodenum
Increased by
Fatty Acids,
Amino Acids,
Oral Glucose
Inc by
starvation
Inc by
Distension,
Vagal
Stimulation
Dec By
Adrenergic
Imput
Inhibits
secretion of
GH, Insulin,
Glucagon.
Used in
Insulinoma,
Acromegaly,
Esophageal
Varices,
Carcinoid
Syn
Stimulates
Neuronal
Muscarinic
Pathways
Neutralises
Gastric acid
Also Called
GASTRIC
INHIBITORY
PEPTIDE
ERYTHROMY
CIN stimulates
intestinal
receptors to
stimulate
intestinal
peristalsis
VIPoma =
(WDHA)
WATERY
DIARRHOEA
HYPOKALEMI
A
ACHLORHYD
Nitric Oxide
RIA
Its loss causes
ACHALASIA