Farmasetika Dasar II

Najma Annuria Fithri, M.Sc., Apt.

Universitas Sriwijaya
Genap 2013/2014

Pertemuan 7
Inkompatibilitas Sediaan Cair

Incompatibility
Pharmaceutical
- Physical immiscibility, insolubility,
precipitation, liquefication
- Chemical sedimentation, redox, colour
change, acid base reaction, instability
Therapeutic
Unwanted response, OD, drug interaction,
antagonist action, contraindication

Therapeutical interaction
1. Antagonist action
Ex: vasodilators + vasoconstrictors

2. Hindrance of drug activity

Ex: decomposition (hydrolysis, oxidation)
3. Complex molecule less absorbed drug
Ex: tetracycline + milk

Drug Combination
1. Synergist effect stronger effect
Ex: drugs with similar mechanism of action

2. Antagonist effect weaker effect

Ex: vasodilator + vasoconstrictor
depressant + stimulant

Problem solving - Therapeutical

1. Interlude between drug intake
2. Dosage monitoring
3. Replace one/more drugs

Problem solving - Pharmaceutical

1.
2.
3.
4.
5.
6.
7.

Mixing steps modification

Co-solvent
Replace excipients/active drugs
Increase of volume
Emulsification emulgator
Suspension formation suspending agent
Separation of drugs

Example
R/
Ephedrin
Champor
Menthol
Aq
qs
m.f.pot.

1
1
1
ad 100

Answer
Ephedrin water soluble
Camphor and methol insoluble

Camphor and menthol combined liquefication

add water add ephedrin

 R/
Mg carbonate
Citric acid
Natrii Bic
Aq.bull. Ad
m.f.pot.

3
3
3
100

Answer
Mg carbonate insoluble in water
Natrii bic + citric acid mix with hot water ad
MgCO3 little by little wait until gas bubble
dissolve continue addition

 R/
Mercuri iod1
Timol
Aquadest ad
m.f.sol.
R/
Terpin hidrat
Alcohol
Glycerin
Aq ad
m.f.sol.

2
60

(1:15 alc)

2
15
20
100

(1:13 alc)

 R/
Phenobarbital Na
Aq.menth.pip.gtt
m.f.pot.

2
2

R/
Na bromida
Ol.sasami
Aqua
qs
m.f.pot.

5
25
ad 120

 R/
Sulfadiazine
Pot.nig.c.tuss
Syr.thymi.
m.f.pot.

500
Aa

200 ml