aaa Teble 4-2. Mechanism of scion of selected ronpepde nerotansmiters. a Protos eed a ee fee ee a an f im F eo esc AM | it owe eso ty een pies no = eat ~ ze ini Be AAP Face torsos erin 1; OG ncn, ena fete ca nae ie i ae « ‘oe. 0 ees inpenitnnllgh ‘kyeicane te = sce a fe Toyeic we Len enone eC =o ea i = om _— ee ee =" = ioe fhe ga hy Sa Ny Sa Neos oc ‘Berets ca dave MF nae nd DAG apne whose A Figure 174, irs ron corbin someting Pa aac = re "eon Figure 20-10. ‘Mechanism of ction of ACTH on cor sob secreting cells inthe Inner two zones of the adrenal ‘cortex. When ACTH binds tots receptor I, aderyi ‘clase (AC) is activated via G, The resulting increase in ‘AMP activates protein kinase A and the kinase phos- DPhorylates cholesteryl ester hydrolase (CE, increasing Ins activity. Consequently, more free cholesterol s ormed and corverted to pregnenalone in the mito- ‘chondria. Note that in the subsequent steps in steroid blosynthesis, products are shuttled between the ito- choncria and the smooth endoplasmic reticulum (SER) Corticosterone is also synthesized and secreted.Figure 20-8, Outre of ermon isynthessnthe onan andor cas che aden core, ‘Thema secretor pout undrined The eneyes othe reacts reshownontheleftand tthe topo ‘hechar.When@ paula enzymes deen mone producto i lctedat the pinsndeated bythe shaded bs,